Sequential Determination of Crp, Alpha-1-Antitrypsin and Haptoglobin in Neonatal Septicaemia

Speer, C.-H. P.

doi:10.1097/00006454-198403000-00032

Cited by 15 publications

(19 citation statements)

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“…Withinrun and day-to-day precision in our study was excellent and low CRP concentrations observed in samples obtained from infected babies on admission were not due to imprecise methodology. The most plausible explanation for the discrepancy between out results and those of Sabel and Wadsworth [19] and of Speer et al [22] is that all of our samples were taken on admission to the neonatal unit and not necessarily when clinical signs of infection first became apparent. The low values of CRP concentration observed in infected babies on admission must therefore have been obtained in the very early stages of the infective process.…”

Section: Crp White Celt Count and Differentialcontrasting

confidence: 56%

Diagnostic audit of C-reactive protein in neonatal infection

1987

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A prospective study of 250 consecutive neonatal admissions to a regional perinatal referral centre and of 10 additional consecutive cases with culture-proven neonatal septicaemia was undertaken. Quantitative C-reactive protein (CRP) determination, white cell count and differential were performed on blood samples obtained from all babies on admission, as well as 10-14 h and 22-26 h later. Using clinical signs, chest X-rays, blood cultures, tracheal aspirates obtained within 4 h of delivery and an abnormal immature/total neutrophil ratio (I/T), infected babies were defined as belonging to one of the following groups: culture-proven septicaemia (n = 19); clinical septicaemia (n = 35); congenital pneumonia (n = 28). The sensitivity, specificity, positive and negative predictive value of CRP were calculated for each sampling time and patient group. No baby had a rise in CRP (greater than 6 mg/l) before an abnormal I/T ratio was first detected. A delayed rise in CRP concentration in the majority of infected babies occurred approximately 12-24 h after the abnormal I/T ratio was first detected. The overall specificity of a CRP level of greater than or equal to 10 mg/l remained approximately constant (97%-94%) while sensitivity increased from 22%-61% with increasing time after admission. The same pattern emerged if each patient group was considered separately. The positive predictive value for a CRP level of greater than or equal to 10 mg/l 22-26 h after admission was 83% and the negative predictive value 82%. CRP had no value in the early diagnosis of neonatal infection. Its main role lies rather in the exclusion or confirmation of infection 24 h after the first clinical suspicion.

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Section: Crp White Celt Count and Differentialcontrasting

confidence: 56%

Diagnostic audit of C-reactive protein in neonatal infection

1987

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“…16 Total leukocyte counts are particularly unreliable indicators of infection during the first several hours of early-onset (within 48 hours of birth) sepsis because they are normal at the time of initial evaluation in more than one third of infants with proven bacteraemia. [17][18][19][20][21][22][23][24][25][26][27][28][29] Conversely, among neonates evaluated for suspected sepsis, far less than half of neonates with reduced (<5000 cells/mm 3 ) or elevated (>20,000 cells/mm 3 ) cell counts are ultimately identified to be infected. 17,19,21,28 The current study signifies that in early onset sepsis, total count are showing more significant increase in early neonatal sepsis as compared to late onset sepsis.…”

Section: Neonatal Sepsis and Total Leukocyte Countmentioning

confidence: 99%

Relationship between gestational age and mode of delivery with neonatal septicemia

Mehar

Agarwal

Singh

et al. 2016

Int J Contemp Pediatr

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“…In the majority of published reports, upper limits for CRP during the neonatal period have been obtained from symptomatic uninfected patients (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72). Thus there are few studies of upper limits for CRP in the healthy newborn (73)(74)(75)(76).…”

Section: Normal (And Abnormal) Ranges In the Newborn Infantmentioning

confidence: 99%