Sequential Development of Hepatic Lesions of Ascaridosis in Colostrum‐deprived Pigs*

Copeman, D. B.; Gaafar, S. M.

doi:10.1111/j.1751-0813.1972.tb05154.x

Cited by 22 publications

(15 citation statements)

References 22 publications

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“…In A. suum infections, white spots (WS) are white pathological lesions that are formed by the mechanical injury and inflammatory response induced by migrating larvae in the liver [69]. WS formation over the superficial hepatic surface and within the liver tissue is characteristic of porcine infections in response to larval migration through the liver [66,68].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…The granulation tissue type WS (GT-WS) have been suggested to form along the larval migration routes (small GT-WS) or encapsulate trapped larvae (large GT-WS) [67][68][69] and therefore have been proposed to play a role in immunity to A. suum infection in pigs [68]. The larvae-induced GT-WS have been proposed as a precursor to the lymphonodular types WS (LN-WS) [68,69], as the appearance of the latter on day 10 p.i. in pigs coincides with the healing of GT-WS [22].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…An inflammatory reaction in the liver has been observed in A. lumbricoides- [64] and A. suum- [65] infected humans, pigs [66][67][68][69] and model organisms such as calves [70], M A N U S C R I P T…”

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confidence: 99%

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Ascaris and ascariasis

Dold

Holland

2011

Microbes and Infection

244

197

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Ascaris lumbricoides and Ascaris suum are widespread parasitic nematodes of humans and pigs respectively. Recent prevalence data suggests that approximately 1.2 billion people are infected. Adult worms exhibit an overdispersed frequency distribution in their hosts and individuals harbouring heavy burdens display associated morbidity. In this review, we describe the parasite, its distribution and measures undertaken to control infection.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

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Ascaris and ascariasis

Dold

Holland

2011

Microbes and Infection

244

197

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“…As no the lesions were observed on the liver from chickens of group A in this study, our results may agreed with their finding. Based on the findings in chickens of groups B and C, it seems likely that multiple infections with A. suum might be involved in the appearance or enhancement of liver lesions similar to the findings in pigs experimentally infected with A. suum [5,17]. No typical 'milk spot' lesions with fibrous changes [5] as observed in the livers of Ascaris infected pigs, were found macroscopically in the present study.…”

Section: Similar To the Visceral Larval Migrans (Vlm) Of Toxocara Canmentioning

confidence: 41%

“…Histopathologically, this change is a focal increase in the width of the interlobular connective tissue [12]. An inflammatory response with infiltration of lymphocytes and eosinophils occurred in the liver of the lambs infected with A. suum eggs, but because of the absence of the interlobular connective tissue, the reaction was mild and confined to areas of larval migration in the adjacent portal triads [4,5]. The difference in the intensity of the lesions was probably due to anatomical differences of the interlobular connective tissue in the livers between lambs and pigs [4].…”

Section: Similar To the Visceral Larval Migrans (Vlm) Of Toxocara Canmentioning

confidence: 99%

Hepatic Lesions Caused by Migrating Larvae of <i>Ascaris suum</i> in chickens

Yoshihara¹,

Hattori²,

Nishizono³

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Group A consisted of chickens infected with a single dose of Ascaris suum and group B of chickens infected with two successive doses. At days 1, 3, 7, 14 and 21 after the first or second infection dose, six chickens from each group were sacrificed. In both groups, larvae were recovered from the livers on days 1, 3, and 7 and lungs on days 3 and 7. No larvae were detected in chickens on day 14. Clear white lesions were noticed only on the livers from chickens of group B at day 7 but had disappeared at day 14. A comparison with group B showed mild histological changes that developed relative to the livers from group A. KEY WORDS: Ascaris suum, chickens, visceral larval migrans.J. Vet. Med. Sci. 70(10): 1129-1131, 2008 Similar to the visceral larval migrans (VLM) of Toxocara canis (T. canis) infection [3], Ascaris suum (A. suum) infection in humans has been reported in Japan [2,8,10,11,15]. It was considered that at least three human cases were caused by eating fresh raw meat and liver from cattle or chickens [2,8,10]. These reports suggest that chickens may play an important role in the zoonotic transmission of A. suum. To clarify the VLM of A. suum larvae in infected chickens, an investigation was carried out on the distribution of larvae and the pathological changes in the livers.Fresh A. suum eggs were obtained from female worms at a local abattoir. Embryonation of the eggs was performed as described by Tsuji et al. [16]. A total number of 65 male broiler chickens aged about 20-days old were used. Initially, groups A (chickens infected with a single dose of A. suum) and B (chicken infected two successive dose) of 30 chickens each received 10,000 eggs and were kept in cages. The same number of eggs were given again to chickens of group B 17 days after the first dose. On days 1, 3, 7, 14, and 21 after the first or second infection, six chickens from each group were sacrificed by cervical dislocation. Larvae were collected from the liver (lobus dexter), lung, pectoral muscle (musculus pectoralis profurdus; about 30 g), and the duodenum (without contents and mucus) using the Baerman method. The contents and mucus of the duodenum were fixed separately in 5% formalin solution and examined microscopically. A video micrometer was used for the measurement of the length of larvae. Statisitical analysis of differences in larval counts between both groups on the same day after first or second infection was done using Statisitica (Stat Soft, Tulsa, OK, U.S.A., P<0.05). The liver (lobus sinister) was investigated macroscopically and fixed in 10% buffered formalin solution. Paraffin sections were stained with hematoxylin and eosin (HE) or with Azan. To examine the lesion in repeatedly infected animals, remaining 5 chickens (group C) were infected with 10,000 eggs twice weekly for five weeks and sacrificed 7 days after the final infection.No clinical signs were observed in any of the infected chickens during the study period. Table 1 shows the distribution of A. suum larvae in chickens of groups A and B. Larvae were ...

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Nematoda: Ascaris lumbricoides

Dold

2012

Immunity to Parasitic Infection

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Sequential Development of Hepatic Lesions of Ascaridosis in Colostrum‐deprived Pigs*

Cited by 22 publications

References 22 publications

Ascaris and ascariasis

Ascaris and ascariasis

Hepatic Lesions Caused by Migrating Larvae of <i>Ascaris suum</i> in chickens

Nematoda: Ascaris lumbricoides

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