Sequential expression and differential function of multiple enamel proteins during fetal, neonatal, and early postnatal stages of mouse molar organogenesis

Slavkin, Harold C.; Bessem, Conny; Bringas, Pablo; Zeichner‐David, Margarita; Nanci, Antonio; Snead, Malcolm L.

doi:10.1111/j.1432-0436.1988.tb00793.x

Cited by 97 publications

(81 citation statements)

References 46 publications

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“…Therefore, the electron microscopic observations of the presence of electron dense granules in the vesicles with antiamelogenin polyclonal antibody on the ovalbumin-treated section may not indicate the vesicular localization of amelogenin. It is possible that these granules reacting to the anti-amelogenin polyclonal antibodies could be due to other enamel proteins, such as enamelin, for it is known that the antibodies produced against amelogenin cross-react with other enamel proteins such as enamelin (29,(31)(32)(33). In support, the polyclonal antibodies produced against recombinant amelogenin also stain more than 15 fractions, ranging from 14 to 42 kDa (30).…”

Section: Discussionmentioning

confidence: 97%

Amelogenin Interacts with Cytokeratin-5 in Ameloblasts during Enamel Growth

Ravindranath

Basilrose

Ravindranath

et al. 2003

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 97%

Amelogenin Interacts with Cytokeratin-5 in Ameloblasts during Enamel Growth

Ravindranath

Basilrose

Ravindranath

et al. 2003

Journal of Biological Chemistry

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“…Decorin follows the same type of expression pattern as that of fibronectin. Tenascin is associated with the basement membrane, and both it and amelogenin increase during the differentiation process (Thesleff et al, 1987a;Slavkin et al, 1988;Uchida et al, 1991).…”

Section: Balling Personal Communication) Since Activin Amentioning

confidence: 99%

The Genetic Control of Early Tooth Development

Maas

Bei

1997

Critical Reviews in Oral Biology & Medicine

209

153

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Most vertebrate organs begin their initial formation by a common, developmentally conserved pattern of inductive tissue interactions between two tissues. The developing tooth germ is a prototype for such inductive tissue interactions and provides a powerful experimental system for elucidation of the genetic pathways involved in organogenesis. Members Msxl is required for the transmission of Bmp4 expression from dental epithelium to mesenchyme and also for Lefi expression.In addition, we consider the role of other signaling molecules in the epithelial-mesenchymal interactions leading to tooth formation, the role that transcription factors such as Msx play in the propagation of inductive signals, and the role of extracellular matrix. Last, as a unifying mechanism to explain the disparate tooth phenotypes in Msxl-and Msx2-deficient mice, we propose that later steps in tooth morphogenesis molecularly resemble those in early tooth development. )from a series of instructive and permissive cell-cell interactions (Saxen, 1977a;Wessells, 1977). The determination of the mesoderm and neural plate in vertebrate embryos is referred to as primary induction (Spemann and Mangold, 1924), and is followed by a series of secondary inductive events which further regulate embryonic organ development. Over the last decade, the application of molecular biology to problems in vertebrate development has revealed a considerable amount of information about the nature of the inductive signals which are exchanged between tissue layers during inductive tissue interactions (reviewed in Jessell and Melton, 1992;Kessler and Melton, 1994). This review focuses specifically on the genetic hierarchies which appear to operate during early tooth development, on the nature of the inductive signals which are exchanged between the dental epithelium and mesenchyme, and on the role that one particular class of transcription factors, those belonging to the Msx family of homeobox genes, plays in controlling these inductive tissue interactions. Several excellent recent reviews on tooth development are also available (Ruch, 1995;Sharpe, 1995;Thesleff et al., 1995a Thesleff et al., ,b, 1996 Thesleff and Sahlberg, 1996), and a "tooth gene expression database" is also available on the Internet (http://honeybee.helsinki.fi/toothexp).The dentition not only constitutes a major component of the mammalian craniofacial system, but also provides a powerful and potentially general model for the study of organ development. The possibility of in vitro cultivation, access to cytological and molecular studies, the clear delineation of epithelial and mesenchymal components, the easily distinguished characteristics of ameloblasts and odontoblasts, and the anteroposterior, position-dependent pattern of dentition make the devel-4

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“…Between the inner epithelium of the enamel organ and the odontoblastic cells of the dental papilla there is a typical basal membrane [Pannese, 1962;Decker, 1963;Frank and Nalbandian, 1967;Reith, 1967;Kallenbach, 1971] which, due to its particular position, could according to Ruch [1987] mediate the epitheliomesenchymal interactions which control differentiation of both types of cells. With regard to this, it is important to underline that the basal membrane which accompanies all stages of morphogenesis and cytodifferentiation disappears [Reith, 1967;Kallenbach, 1971;Sawada et al, 1990] on deposition of the first enamel-like proteins in the developing ECM [Slavkin et al, 1988;Nanci et al 1992].…”

Section: Discussionmentioning

confidence: 99%

Actin-Associated Proteins in Ameloblast Differentiation

Cutroneo¹,

Anastasi²,

Donadio³

et al. 2002

Cells Tissues Organs

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Focal contacts are systems of adherens junctions of the cell-extracellular matrix type, which allow the transfer of fundamental signals from the extracellular matrix to nuclear compartments, capable of regulating adhesion, proliferation, migration and differentiation of cells. Recently, many authors have concentrated their attention on epitheliomesenchymal interactions which guide organogenesis of dental germ, identifying numerous growth and differentiation factors and having the inner enamel epithelial cells of the enamel organ as a target. Given that the two cellular compartments in their tooth germ are separated by a basal membrane and by an extracellular matrix, which touches it, we wanted to evaluate the presence of focal contacts through the identification of talin and vinculin, proteins of the actin-associated protein complex. In this study we utilized the hemimandibles of young Wistar rats and we extracted the related odontogenic tooth organs present at their apical end. Specimens are processed with antibody against vinculin and talin. Results show that these junctional system proteins are present at the apical poles of both cellular compartments suggesting that putative epithelial-mesenchymal interactions, other than marker molecules, may use focal contacts as a system for transmission of signals.

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Sequential expression and differential function of multiple enamel proteins during fetal, neonatal, and early postnatal stages of mouse molar organogenesis

Cited by 97 publications

References 46 publications

Amelogenin Interacts with Cytokeratin-5 in Ameloblasts during Enamel Growth

Amelogenin Interacts with Cytokeratin-5 in Ameloblasts during Enamel Growth

The Genetic Control of Early Tooth Development

Actin-Associated Proteins in Ameloblast Differentiation

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