Sequential extraction and enrichment of flavonoids from Euonymus alatus by ultrasonic-assisted polyethylene glycol-based extraction coupled to temperature-induced cloud point extraction

Mai, Xiaoman; Liu, Yingtao; Tang, Xunyou; Wang, Liping; Lin, Yimo; Zeng, Huiyun; Luo, Laicheng; Fan, Huajun; Li, Pingfan

doi:10.1016/j.ultsonch.2020.105073

Cited by 46 publications

(17 citation statements)

References 43 publications

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“…Several studies have evaluated the optimum pH to extract flavonoids from plant matrices. A recent report (Mai et al, 2020 ) investigated the influence of the pH of the solvent on the recovery of Euonymus alatus flavonoids and suggested that recoveries increased in acidic pH (2.5–3.5) and decreased at higher pH. Another report, which in this case evaluated polyphenols, indicated that its extraction from pomegranate peel is affected by the solvent's pH, with the best results being observed in acidic medium (Motikar et al, 2020 ).…”

Section: Advanced Extractions Techniquesmentioning

confidence: 96%

Extraction of Flavonoids From Natural Sources Using Modern Techniques

et al. 2020

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Flavonoids are one of the main groups of polyphenols found in natural products. Traditional flavonoid extraction techniques are being replaced by advanced techniques to reduce energy and solvent consumption, increase efficiency and selectivity, to meet increased market demand and environmental regulations. Advanced technologies, such as microwaves, ultrasound, pressurized liquids, supercritical fluids, and electric fields, are alternatives currently being used. These modern techniques are generally faster, more environmentally friendly, and with higher automation levels compared to conventional extraction techniques. This review will discuss the different methods available for flavonoid extraction from natural sources and the main parameters involved (temperature, solvent, sample quantity, extraction time, among others). Recent trends and their industrial importance are also discussed in detail, providing insight into their potential. Thus, this paper seeks to review the innovations of compound extraction techniques, presenting in each of them their advantages and disadvantages, trying to offer a broader scope in the understanding of flavonoid extraction from different plant matrices.

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Section: Advanced Extractions Techniquesmentioning

confidence: 96%

Extraction of Flavonoids From Natural Sources Using Modern Techniques

et al. 2020

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“…The pH can also affect the interaction between the functional groups of the adsorbent and the compound, facilitating its elution ( Berrueta, Gallo, & Vicente, 1995 ). There is also evidence that pH may improve the extraction of some phenolic compounds, such as anthocyanins ( Garcia-Mendoza et al, 2017 ), catechin, and dihydromyricetin ( Mai et al, 2020 ), among other flavonoids ( Motikar et al, 2020 , Soquetta et al, 2019 ). Thus, the pH of the extraction solvent was adjusted to 4.0 and 8.0 to assess the effect on the process ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Simultaneous extraction and separation of compounds from mate (Ilex paraguariensis) leaves by pressurized liquid extraction coupled with solid-phase extraction and in-line UV detection

Souza

Silva

Chaves

et al. 2021

Food Chemistry: Molecular Sciences

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“…The extraction methods of flavonoids used in Chinese medicine primarily include solvent extraction, ultrasonic extraction, and enzymatic hydrolysis [8][9][10]. Each extraction method has its advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Enzymatic Extraction of Flavonoids from Armeniaca mume Sieb. Blossom and Their Immunomodulating Effect in Mice with DSS-Induced Colitis

Yao

Adhikari

et al. 2021

Molecules

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Armeniaca mume Sieb. blossom is among the traditional Chinese edible flowers, and it is widely used in the food and pharmaceutical industries. Flavonoids are among the most abundant bioactive compounds in A. mume Sieb. blossom. However, the research on the extraction of flavonoids from A. mume Sieb. blossom and their immunomodulating function is insufficient. In this study, we developed a microwave-assisted enzymatic extraction of flavonoids from A. mume Sieb. blossom (FAMB) and explored their immunomodulating effect on mice with dextran sulfate sodium salt-induced colitis. The results showed that the optimum parameters for microwave-assisted enzymatic extraction of FAMB were as follows: cellulase: 2.0%; microwave power: 200 W; microwave action time: 5 min; and enzymatic hydrolysis time: 50 min. FAMB significantly promoted the lymphocyte proliferation and natural killer (NK) cell killing activity in colitis mice, and increased the concentrations of TNF-α, IFN-γ, and IL-2 in serum. FAMB also significantly reduced the apoptosis of spleen lymphocytes in these mice. These results demonstrated that the microwave-assisted enzymatic method could significantly improve the yield and efficacy extraction of FAMB. FAMB showed a good immunomodulation effect on colitis mice.

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Sequential extraction and enrichment of flavonoids from Euonymus alatus by ultrasonic-assisted polyethylene glycol-based extraction coupled to temperature-induced cloud point extraction

Cited by 46 publications

References 43 publications

Extraction of Flavonoids From Natural Sources Using Modern Techniques

Extraction of Flavonoids From Natural Sources Using Modern Techniques

Simultaneous extraction and separation of compounds from mate (Ilex paraguariensis) leaves by pressurized liquid extraction coupled with solid-phase extraction and in-line UV detection

Microwave-Assisted Enzymatic Extraction of Flavonoids from Armeniaca mume Sieb. Blossom and Their Immunomodulating Effect in Mice with DSS-Induced Colitis

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