Sequential rearrangement and stereochemical reorganization to design an antimicrobial peptide with enhanced stability

Rejuvenation of Meropenem by Conjugation with Tilapia Piscidin-4 Peptide Targeting NDM-1 Escherichia coli

“…L-Amino acids form righthanded helices while D-amino acids form left-handed helices; thus, altering the chirality of AMPs can prevent recognition by proteases. 20,21 Antibacterial Activity of Conjugates. The synthesized conjugates were examined for their antibacterial activity against selected Gram-positive and Gram-negative clinical strains.…”

“…In order to confer resistance to proteases such as trypsin, chymotrypsin, proteinase K, and pepsin, TP4 composed of d -amino acids was utilized for conjugation in this study. l -Amino acids form right-handed helices while d -amino acids form left-handed helices; thus, altering the chirality of AMPs can prevent recognition by proteases. , …”

“…l -Amino acids form right-handed helices while d -amino acids form left-handed helices; thus, altering the chirality of AMPs can prevent recognition by proteases. 20 , 21 …”