Sequential self-assembly and disassembly of curcumin hydrogel effectively alleviates inflammatory bowel disease

Zhang, Lele; Ren, Xiaopeng; Zhou, Peirong; Wu, Fangzheng; Liu, Li; Hai, Zijuan

doi:10.1039/d2bm01120d

Cited by 12 publications

(4 citation statements)

References 47 publications

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“…In another study, instead of directly loading curcumin, Cur-FFEYp, the Cur precursor Cur–Phe–Phe–Glu–Tyr (H 2 PO 3 )–OH, was capable of local self-assembly into hydrogels via dephosphorylation and then disassembly for release by esterase in inflamed regions. This novel strategy can markedly enhance the anti-inflammatory effect of curcumin and was found to alleviate two types of IBD [ 187 ]. Human serum albumin (HSA), a U.S. FDA-approved nanomaterial, possesses various advantages, including good biocompatibility, biodegradation, water solubility, low cytotoxicity, and non-immunogenicity.…”

Section: Emerging Strategies Promote the Application Of Polyphenols I...mentioning

confidence: 99%

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Peng

Ding

et al. 2023

Antioxidants

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Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated with oxidative stress, unbalanced gut microbiota, and aberrant immune response. Indeed, oxidative stress can affect the progression and development of IBD by regulating the homeostasis of the gut microbiota and immune response. Therefore, redox-targeted therapy is a promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, are able to maintain redox equilibrium in the intestinal tract to prevent abnormal gut microbiota and radical inflammatory responses. Here, we provide a comprehensive perspective for implementing natural antioxidants as potential IBD candidate medications. In addition, we demonstrate novel technologies and stratagems for promoting the antioxidative properties of CHM-derived polyphenols, including novel delivery systems, chemical modifications, and combination strategies.

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Section: Emerging Strategies Promote the Application Of Polyphenols I...mentioning

confidence: 99%

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Peng

Ding

et al. 2023

Antioxidants

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“…RNA isolation and RT-qPCR were described previously ( 59 ). Briefly, total RNAs were isolated from different cell lines or mouse tissues using TRIzol reagent (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes

et al. 2023

Self Cite

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RNA helicase DHX9 has been extensively characterized as a transcriptional regulator, which is consistent with its mostly nucleic localization. It is also involved in recognizing RNA viruses in the cytoplasm. However, there is no in vivo data to support the antiviral role of DHX9; meanwhile, as a nuclear protein, if and how nucleic DHX9 promotes antiviral immunity remains largely unknown. Here, we generated myeloid-specific and hepatocyte-specific DHX9 knockout mice and confirmed that DHX9 is crucial for host resistance to RNA virus infections in vivo. By additional knockout MAVS or STAT1 in DHX9-deficient mice, we demonstrated that nucleic DHX9 plays a positive role in regulating interferon-stimulated gene (ISG) expression downstream of type I interferon. Mechanistically, upon interferon stimulation, DHX9 is directly bound to STAT1 and recruits Pol II to the ISG promoter region to participate in STAT1-mediated transcription of ISGs. Collectively, these findings uncover an important role for nucleic DHX9 in antiviral immunity.

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“…Later on, several scientists developed methods for high yield synthesis of curcumin which are in use today . Curcumin is the most widely used plant-based drug with various pharmacological benefits, including anti-inflammatory, antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-parasite, and anti-cancer. − Numerous preclinical studies have proven curcumin to be effective in several cancers because of curcumin’s capability to induce G2/M cell cycle arrest, trigger apoptosis, induce autophagy, disturb molecular signaling, inhibit invasion and metastasis, and increase the efficiency of existing chemotherapeutics. , The inflammatory response of curcumin is often steered by the radical production of pro-inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). , Consequently, the downregulation of pro-inflammatory cytokines may effectively reduce the incidence of inflammation . Curcumin is also involved in other signaling pathways like it induces degranulation in human neutrophils by increasing the cell surface expression of clusters of differentiation 35 (CD35), CD66b, and CD63 .…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

et al. 2023

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Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.

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Sequential self-assembly and disassembly of curcumin hydrogel effectively alleviates inflammatory bowel disease

Abstract: Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract with unclear etiology and insufficient therapeutic efficacy. The development of specific, effective and safe IBD...

Cited by 12 publications

References 47 publications

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

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