Sequential Therapy Compared with Standard Triple Therapy for Helicobacter Pylori Eradication in Children: A Double-Blind, Randomized, Controlled Trial

Meta‐analysis: sequential therapy for Helicobacter pylori eradication in children

“…Of the included studies, 10 RCTs met the inclusion criteria . However, only five were full‐text publications; the remaining five trials were published only in abstract form . Except one publication in Chinese that was translated, all trials were published in English.…”

Clinical differences of Helicobacter pylori infection in children

“…51 Sequential therapy, which includes dual therapy with PPI and amoxicillin for 5 days, followed by 5 days of triple therapy: PPI with clarithromycin and metronidazole/tinidazole has also been used in the last decade. [63][64][65][66][67] If H .pylori resistance to clarithromycin is high in the given region, PPI therapy in combination with bismuth and two antibiotics is recommended.…”

Ornidazole-based sequential therapy is not effective in Helicobacter pylori eradication in children

“…Kalach et al (13) showed that the eradication rates were similar in standard (80%) and sequential therapy (84.6%) groups in children infected with H. pylori. In a recent study from Poland, sequential therapy resulted in higher eradication rates compared to standard triple therapy (14). However, Yang and Sheu (15), using metronidazole instead of tinidazole in sequential therapy, did not show superiority in terms of eradication rates compared to standard triple therapy.…”