Serial analysis of serum and ascitic fluid levels of soluble adhesion molecules and chemokines in patients with spontaneous bacterial peritonitis

Girón-González, José A; Rodríguez-Ramos, Claudio; Elvira, J.; Galán, Fátima; Álamo, C. Fernández Gutiérrez del; Díaz, Fernando; Martín‐Herrera, L.

doi:10.1046/j.1365-2249.2001.01414.x

Cited by 40 publications

(29 citation statements)

References 36 publications

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“…This study aimed at evaluating the role of serum calprotectin as a non-invasive diagnostic marker for SBP in Egyptian cirrhotic patients in comparison to CRP. Regarding the ascitic fluid cell count in the current study, there were higher levels of ascitic TLC and PMNL count in SBP group in comparison to the group with sterile cirrhotic ascites, and this result is in agreement with Girón-González et al (16) , Yildirim et al (17) and Abdel-Razik et al (18) . As regards ascitic fluid total protein, it was significantly higher in SBP group than in sterile cirrhotic ascites group (P<0.001).…”

Section: Discussionsupporting

confidence: 92%

Serum Calprotectin as a Non-invasive Diagnostic Marker for Spontaneous Bacterial Peritonitis in Egyptian Cirrhotic Patients

Helmy¹

2016

jmscr

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Section: Discussionsupporting

confidence: 92%

Serum Calprotectin as a Non-invasive Diagnostic Marker for Spontaneous Bacterial Peritonitis in Egyptian Cirrhotic Patients

Helmy¹

2016

jmscr

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“…[6][7][8][9][10][11] Experiments were performed using an in situ perfusion system of the rat femoral bone marrow. Thus, the chemokine rat MIP-2 was infused directly into the femoral bone marrow via the femoral artery, and mobilized leukocytes were collected via cannulation of the femoral vein.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that plasma levels of CXC chemokines rise during inflammatory reactions and contribute to the acute release of neutrophils from the bone marrow. [6][7][8][9][10][11] Therefore, to mimic an inflammatory reaction we have infused a pulse of the CXC chemokine, rat macrophage inflammatory protein-2 (MIP-2) to stimulate an acute mobilization of neutrophils from the bone marrow.…”

Section: Introductionmentioning

confidence: 99%

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Burdon

Martin

Rankin

2005

Blood

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The acute release of neutrophils from the bone marrow is a critical step in their trafficking to sites of inflammation. This process is stimulated by systemically acting inflammatory mediators, such as the CXC chemokines. In this study we have used a novel in situ perfusion system of the rat femoral bone marrow to directly investigate the role of specific adhesion molecules in chemokine-stimulated neutrophil mobilization. We show here that neutrophils mobilized in response to rat macrophage inflammatory protein-2 (MIP-2) shed L-selectin and expressed significantly higher levels of CD11b and CD49d. However, inhibition of L-selectin sheddase activity with KD-IX-73-4 had no effect on the number of neutrophils mobilized in response to rat MIP-2. Blockade of CD18, using a neutralizing monoclonal antibody (mAb), did not inhibit neutrophil mobilization but unexpectedly increased the rate and number of neutrophils released from the bone marrow in response to chemokine, suggesting that CD18 could play a role in neutrophil retention within the bone marrow. Blockade of CD49d using either a selective mAb or a specific antagonist resulted in a dramatic inhibition (> 75%) of the chemokine-stimulated neutrophil mobilization from the bone marrow. These data reveal contrasting roles for CD18 and CD49d in the retention and release of neutrophils from the bone marrow. (Blood. 2005;105:2543-2548)

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“…Many previous studies reported increased sICAM-1 and sVCAM-1 values in patients with inflammatory diseases of the liver (34)(35)(36)(37)(38). While, elevated serum VCAM-1 in chronic hepatitis have been reported by some authors (39,40).…”

Section: Discussionmentioning

confidence: 87%

Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients

Al-Jiffri

2017

Electron J Gen Med

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Background:Currently, about 2% of population are affected with hepatitis C worldwide, chronic hepatitis C (CHC) is the major cause of hepatic cirrhosis and referral for liver transplant. However, there is a high need for noninvasive methods for assessment of hepatocellular damage. Objective: The purpose of this study was to determine the strength of the association between adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients. Methods: One hundred patients with chronic hepatitis C virus infection(64 males and 36 females, their age ranged from 28 to 53 years with circulating anti-HCV antibodies were equally categorized into two study groups: patients with CHC and patients with liver cirrhosis (LC). Also, one fifty healthy subjects were included as healthy controls. Serum alanine aminotransferase (ALT), soluble intercellular adhesion molecule1 (sICAM-1); Soluble vascular adhesion molecule 1(sVCAM-1); Soluble E-selectin(s-E-selectin) and Tumor necrosis factor-alpha (TNF-α) were assayed for all participants. Results: We observed elevation with regard to the healthy controls group in the parameters of ALT, sICAM-1, sVCAM-1, s-E-selectin and TNF-α for patients with CHC and patients with liver cirrhosis (LC). Also, a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values was detected. Conclusion:In conclusion, our results confirm that, in patients with chronic virus hepatitis and liver cirrhosis there is a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values. These findings suggest that serum TNF-α levels could be used as a sensitive predictor of liver inflammation, while serum ICAM-1 can be considered as a marker of hepatic necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator for the severity of liver cirrhosis.

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Serial analysis of serum and ascitic fluid levels of soluble adhesion molecules and chemokines in patients with spontaneous bacterial peritonitis

Cited by 40 publications

References 36 publications

Serum Calprotectin as a Non-invasive Diagnostic Marker for Spontaneous Bacterial Peritonitis in Egyptian Cirrhotic Patients

Serum Calprotectin as a Non-invasive Diagnostic Marker for Spontaneous Bacterial Peritonitis in Egyptian Cirrhotic Patients

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients

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