Serial assessment of functional recovery following nerve injury using implantable thin‐film wireless nerve stimulators

Gamble, Paul; Stephen, Manu; MacEwan, Matthew R.; Ray, Wilson Z.

doi:10.1002/mus.25153

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Electromyograms (EMGs) obtained from the gastrocnemius muscle in uninjured animals confirm the ability to stimulate the sciatic nerve at levels well above threshold. These values, as previously reported 39 , correspond to stimulation of all the nerve fibers via the electrodes placed around the target sciatic nerve. Figure 3b-d shows compound muscle action potential (CMAP) data obtained from stimulation of the sciatic nerve with different voltages (at a frequency of 20 Hz) and different frequencies (with an applied voltage of 2.2 V) using monophasic pulses shortly after the surgery and after 145 h of implantation, respectively.…”

Section: And Supplementary Note 8)supporting

confidence: 82%

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

et al. 2020

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Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery.

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Section: And Supplementary Note 8)supporting

confidence: 82%

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

et al. 2020

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“…Measurement of TA muscle activation (in millivolts), evoked by electrical stimulation of the sciatic nerve at 50 Hz, was utilized to assess the functional capacity. The experimental technique and data acquisition were performed as described elsewhere …”

Section: Methodsmentioning

confidence: 99%

What is Normal? Neuromuscular junction reinnervation after nerve injury

et al. 2019

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Introduction In this study we present a reproducible technique to assess motor recovery after nerve injury via neuromuscular junction (NMJ) immunostaining and electrodiagnostic testing. Methods Wild‐type mice underwent sciatic nerve transection with repair. Hindlimb muscles were collected for microscopy up to 30 weeks after injury. Immunostaining was used to assess axons (NF200), Schwann cells (S100), and motor endplates (α‐bungarotoxin). Compound motor action potential (CMAP) amplitude was used to assess tibialis anterior (TA) function. Results One week after injury, nearly all (98.0%) endplates were denervated. At 8 weeks, endplates were either partially (28.3%) or fully (71.7%) reinnervated. At 16 weeks, NMJ reinnervation reached 87.3%. CMAP amplitude was 83% of naive mice at 16 weeks and correlated with percentage of fully reinnervated NMJs. Morphological differences were noted between injured and noninjured NMJs. Discussion We present a reproducible method for evaluating NMJ reinnervation. Electrodiagnostic data summarize NMJ recovery. Characterization of wild‐type reinnervation provides important data for consideration in experimental design and interpretation.

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“…Unfortunately this technology has inconsistent results, low specificity, and a high false-positive rate, which limits its clinical use [ 124 ]. Additionally, nerve stimulators have shown a neuromodulatory benefit when applied to the peripheral nervous system [ 125 , 126 ]. Implantation of a nerve stimulator at the time of RP has therefore been proposed, not only for nerve identification, but for the postoperative regenerative benefits [ 127 ].…”

Section: Surgical Strategies For Neuroprotection During Radical Prmentioning

confidence: 99%

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

Campbell¹,

Burnett²

2017

IJMS

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Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review.

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Serial assessment of functional recovery following nerve injury using implantable thin‐film wireless nerve stimulators

Abstract: This study highlights the ability of implantable wireless nerve stimulators to provide a unique view into the time course of functional recovery in multiple motor targets. Muscle Nerve 54: 1114-1119, 2016.

Cited by 15 publications

References 31 publications

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

What is Normal? Neuromuscular junction reinnervation after nerve injury

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

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