Serial chest CT findings of intravascular large B-cell lymphoma of the lungs

Choi, Eun Jung; Jin, Gong Yong; Chung, Myoung Ja

doi:10.21037/jtd.2018.02.44

Cited by 3 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These CT features have been reported to correlate with thickened alveolar septa owing to the distension of small vessels filled with neoplastic lymphoid cells (19). The clinical, radiological, and pathological findings seen in our case were consistent with those described in previous reports (19)(20)(21)(22).…”

Section: Discussionsupporting

confidence: 91%

“…The main sites of involvement in patients with IVLBCL are the central nervous system, skin, bone marrow, and lymph nodes, and involvement of the lungs has also been re-ported (10,18,19). Clinical manifestations of IVLBCL in the lungs have included a fever, cough, hypoxemia, and progressive dyspnea (18)(19)(20)(21)(22)(23). The common patterns of parenchymal abnormality seen on CT images include bilateral diffuse ground-glass opacity, and in a few cases, peribronchovascular and interlobular septal thickening, nodules, and consolidation (19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations of IVLBCL in the lungs have included a fever, cough, hypoxemia, and progressive dyspnea (18)(19)(20)(21)(22)(23). The common patterns of parenchymal abnormality seen on CT images include bilateral diffuse ground-glass opacity, and in a few cases, peribronchovascular and interlobular septal thickening, nodules, and consolidation (19)(20)(21)(22)(23). These CT features have been reported to correlate with thickened alveolar septa owing to the distension of small vessels filled with neoplastic lymphoid cells (19).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis

et al. 2020

View full text Add to dashboard Cite

A 70-year-old woman with rheumatoid arthritis undergoing methotrexate (MTX) treatment presented with dyspnea and a subfever. Computed tomography (CT) revealed a diffuse minimal ground-glass appearance in both lungs and splenomegaly. The gallium scintigram showed a diffuse, mild uptake in both lungs and the spleen. The lung biopsy specimen revealed the presence of CD20-positive atypical lymphocytes in the small pulmonary vessels. The patient was diagnosed with pulmonary intravascular diffuse large B-cell lymphoma (IVLBCL) and exhibited spontaneous regression after MTX was discontinued. This report describes a rare case of MTX-associated lymphoproliferative disorder expressing pulmonary IVLBCL.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In our series of lymphoma patients, most of the cases were NHL. In published articles, lymphoma generally presents as an isolated mass or enlarged lymph nodes, with homogeneous mild or moderate contrast-enhancement [ 19 , 20 ]. Intra-nodular necrosis or cysts are only occasionally discovered in untreated lymphomas with a large diameter [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Castleman disease versus lymphoma in neck lymph nodes: a comparative study using contrast-enhanced CT

Wang

Yang

et al. 2018

Cancer Imaging

View full text Add to dashboard Cite

BackgroundThe purpose of this study was to determine the contrast-enhanced CT characteristics for differentiating between Castleman disease (CD) and lymphoma in neck lymph nodes.MethodsThis retrospective study evaluated the number (solitary or multiple), strength of contrast-enhancement, type of contrast-enhancement, surrounding vessels, contrast-enhanced Hounsfield unit (HU) values, and anatomical distributions of lymph nodes in 34 patients with confirmed CD and 55 patients with newly diagnosed untreated lymphoma. Independent t-tests, receiver operating characteristic (ROC) curve analysis, and chi-square tests were used to evaluate the variables and CT features.ResultsSeveral significant differences were found between CD and lymphoma. The interval between first contrast-enhanced CT and biopsy/surgery was significantly longer in the CD group (mean 72 ± 105 days, median 60 days) than in the lymphoma patients (mean 30 ± 2 days, median 12 days; p = 0.015). The lymphoma patients presented significantly more often with fatigue and fever (p = 0.023 and p = 0.016 respectively) than did the CD subjects. HU values of nodules after enhancement were significantly higher in the CD patients than in the lymphoma patients. In cases involving multiple lymph nodes, in all the CD cases, all affected nodes were located in only the left or right side of the neck, not bilaterally. ROC analysis showed a significant difference in contrast-enhanced CT attenuation values between lymphoma and CD (p < 0.001, area under the curve = 0.954), with a cut-off value of 92.5 HU. We constructed a decision tree according to these imaging characteristics.ConclusionsContrast-enhanced CT can be useful for differentiating between CD and lymphoma.

show abstract

“…Unicentric Castleman disease is characterized by a painless mass over the mediastinum, axillary, and cervical lymph nodes and nonspecific clinical presentations, 3 with radiographic features that demonstrate intense homogeneous enhancement following contrast on CT (CT). [4][5][6] However, lymphomas share the same features of intense homogeneous enhancement on CT. 7,8 One retrospective study found significantly higher Hounsfield units (HU) in patients with Castleman disease than in patients with lymphoma. 9 However, the HU of a tumor may be affected by several factors, including the timing of image capture and dose and distribution of contrast.…”

Section: Introductionmentioning

confidence: 99%

A novel diagnostic tool for hyaline vascular Castleman disease versus lymphoma based on contrast-enhanced computed tomography in neck mass

Lin

Liao

Shih

et al. 2022

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Background: Castleman disease and lymphoma each have a distinct treatment plan; however, they share the same features on contrast-enhanced computed tomography. Methods: To assess the quantitative outcomes of Castleman disease versus lymphoma using contrast-enhanced computed tomography based on Hounsfield units (HU). We retrospectively reviewed eight patients with unicentric Castleman disease and 30 patients with lymphoma based on pathological diagnosis at China Medical University Hospital between 2015 and 2020. Preoperative computed tomography with contrast scans was reviewed, and the HU of each tumor were measured. Results: This study included eight patients with unicentric Castleman disease (four men and four women; mean age, 33 years) and 25 patients with lymphoma (11 men and 14 women; mean age, 53 years). There was no significant difference in heterogeneity between the two diseases (0.161 ± 0.052 vs 0.239 ± 0.063, p = 0.22); however, enhancement in Castleman disease was higher than that in lymphoma (126.40 ± 31.90 vs 74.19 ± 7.11, p < 0.001), providing a very good diagnostic tool (cutoff point at 88.5-91.3, sensitivity 0.86/specificity 0.88). Furthermore, we found a highly linear relationship in Castleman disease, which was not noted in lymphoma. Conclusion:The value of HU provides a good diagnostic tool for the differential diagnosis of Castleman disease versus lymphoma in the neck lymph nodes. Considering the linear relationship in Castleman disease, an increasingly accurate differential diagnosis can be made.

show abstract

Serial chest CT findings of intravascular large B-cell lymphoma of the lungs

Cited by 3 publications

References 10 publications

Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis

Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis

Castleman disease versus lymphoma in neck lymph nodes: a comparative study using contrast-enhanced CT

A novel diagnostic tool for hyaline vascular Castleman disease versus lymphoma based on contrast-enhanced computed tomography in neck mass

Contact Info

Product

Resources

About