2006
DOI: 10.1097/01.pcc.0000216414.00362.81
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Serial circulating vasopressin levels in children with septic shock*

Abstract: The results of our study suggest that vasopressin levels are elevated in children with septic shock and that serial values up to 96 hrs do not show any decline.

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Cited by 34 publications
(29 citation statements)
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“…Even if VP is released in response to hypovolemia and hypotension, endogenous VP shows a biphasic response in septic shock, with initial high levels followed by inappropriately low levels (10), thus justifying exogenous administration. However, persistently high VP levels were recently detected in children with septic shock (11).…”
Section: Discussionmentioning
confidence: 99%
“…Even if VP is released in response to hypovolemia and hypotension, endogenous VP shows a biphasic response in septic shock, with initial high levels followed by inappropriately low levels (10), thus justifying exogenous administration. However, persistently high VP levels were recently detected in children with septic shock (11).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have demonstrated low endogenous hormone levels in children with vasodilatory shock prior to starting vasopressin 8,9 ; however others report elevated levels and no difference between children with and without septic shock. 10 Depleted vasopressin stores have been identified in children following cardiopulmonary bypass; however, low levels were not accompanied by hemodynamic instability in all patients, nor did they reliably predict patients at higher risk of developing a low cardiac output state. 11 Possible reasons for inconsistencies in measured vasopressin levels between the adult and pediatric studies may be attributed to the difference in hemodynamic physiology seen in children.…”
Section: Vasopressin Response During Shockmentioning
confidence: 96%
“…There is a limited experience with vasopressin in children as a rescue therapy in catecholamine resistant shock; there are no large trials to define its place [72,73]. Moreover, plasma vasopressin is high in children with septic shock and vasopressin may have deleterious effects on renal functions and platelet counts [74][75][76]. At this time, there is no evidence to support inclusion of vasopressin in the management protocol for pediatric septic shock.…”
Section: Vasopressin In Shockmentioning
confidence: 99%