Serial cranial ultrasonography or early MRI for detecting preterm brain injury?

Plaisier, Annemarie; Raets, Marlou M. A.; Ecury-Goossen, Ginette M.; Govaert, Paul; Feijen-Roon, Monique; Reiss, Irwin K M; Smit, Liesbeth S.; Lequin, Maarten H.; Dudink, Jeroen

doi:10.1136/archdischild-2014-306129

Cited by 74 publications

(52 citation statements)

References 29 publications

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“…When predicting outcomes with the signals on T2-quantification MR imaging, infants' ages should be considered cautiously. Although not a very early neuroimaging indicator compared with other studies using term-equivalent age MR imaging, 3 our T2-quantification model could still enhance the clinical judgment in high-risk preterm infants because the diagnosis of cerebral palsy might sometimes be equivocal before 18 months of age.…”

Section: 23mentioning

confidence: 92%

“…2 MR imaging is considered a good tool for early diagnosis of brain injury in prematurity, but the conventional qualitative approach remains subjective. 3,4 The incidence of macroscopic cystic-necrotic periventricular leukomalacia has markedly declined, and new forms of microscopic focal or diffuse nondestructive white matter injury are emerging. 5 However, this microscopic necrosis and gliosis is not readily detected by conventional MR imaging.…”

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confidence: 99%

“…Early quantitative MR imaging in thin slices with autocalculation computer programs may provide more precise prediction than the results in our study. 3,28 However, the simple manual measurement of T2 relaxometry in specific white matter areas could still be useful clinically. Our study focused on the neuroimaging-neurodevelopmental correlations, and the clinical events regarding the perinatal complications were not analyzed.…”

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confidence: 99%

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T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

Chen

Wang

Huang

et al. 2018

AJNR Am J Neuroradiol

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Section: 23mentioning

confidence: 92%

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confidence: 99%

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confidence: 99%

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T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

Chen

Wang

Huang

et al. 2018

AJNR Am J Neuroradiol

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“…Recent multicenter epidemiological studies reported an incidence rate of IVH of 25-30% for very low birth weight infants and even higher for extreme low birth weight infant [4,5]. The described rate for low-grade IVH (grades I-II) is 11% and for severe IVH (grades III-IV) is 3-5% [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Cranial ultrasonography (US) is the most commonly used imaging technique to diagnose IVH, because of its high sensitivity for detecting acute bleeding, its portability, and the lack of ionizing radiation [7].…”

Section: Introductionmentioning

confidence: 99%

Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

Peixoto

Amaral

Resende

et al. 2018

Sci Med

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AIMS: To evaluate the impact of low-grade intraventricular hemorrhage on neurodevelopmental outcome in preterm infants at 24 months of age. METHODS: We conducted a retrospective case-control study of infants with gestational age less than 34 weeks, admitted to a Neonatal Intensive Care Unit between January/2006 and December/2015. Cases were defined as those with low-grade intraventricular hemorrhage (grades I or II), diagnosed by cranial ultrasonography. For each case, a control with the same gestational age but without intraventricular hemorrhage was selected. Follow-up examinations of neurodevelopment were performed at 24 months of age in cases and controls using the Griffiths Mental Development Scale. Cerebral palsy, neurodevelopmental delay (developmental quotient <2 side deviations below the mean), hearing impairment and/or blindness were considered as severe neurodevelopmental impairment. RESULTS: The study included 172 preterm infants: 86 cases and 86 controls. In the univariate analysis, a difference between the two groups was identified for the following clinical findings: antenatal corticosteroid complete cycle (57% in cases vs. 80% in controls; p=0.001; OR: 0.33, 95%CI 0.17-0.64); male gender (63% cases vs. 41% controls; p=0.004; OR: 2.45, 95%CI 1.3-4.5); outborn (26% cases vs. 9% controls; p=0.005; OR: 3.3 95%CI 1.4-8.0); Clinical Risk Index for Babies higher than 5 (24% in cases vs. 12% in controls; p=0.029; OR: 2.4 95%CI 1.1-5.6); intubation in the delivery room (47% cases vs. 27% controls; p=0.007; OR: 2.38 95%CI 1.3-4.5); and neonatal sepsis (34% in cases vs. 20% in controls; p=0.039; OR: 2.1 95%CI 1.03-4.1). After logistic regression, differences were only maintained for antenatal corticosteroid (p=0.005; OR 0.34, 95%CI 0.16-0.72) and male gender (p=0.002; OR 2.9, 95%CI 1.4-5.8). A severe neurodevelopmental deficit was present in three cases (3.5%) and one control (1.2%). No statistically significant differences in outcome were found between cases and controls. CONCLUSIONS: In this sample, preterm infants with low-grade intraventricular hemorrhage diagnosed by cranial ultrasonography had no difference in early neurodevelopmental outcome when compared with controls.KEYWORDS: cerebral intraventricular hemorrhage; preterm infant; neurodevelopmental disorders. RESUMOOBJETIVOS: Avaliar o impacto da hemorragia intraventricular de baixo grau no neurodesenvolvimento de lactentes prematuros aos 24 meses de idade. MÉTODOS: Foi conduzido um estudo de caso-controle retrospectivo em lactentes com idade gestacional inferior a 34 semanas, internados em uma Unidade de Terapia Intensiva Neonatal entre janeiro de 2006 e dezembro de 2015. Os casos foram definidos como aqueles com hemorragia intraventricular de baixo grau (graus I ou II), diagnosticada por ultrassonografia craniana. Para cada caso, foi selecionado um controle com a mesma idade gestacional, mas sem hemorragia intraventricular. A avaliação do neurodesenvolvimento foi realizada aos 24 meses de idade, em casos e controles, com a Escala de Desen...

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Progress in the Application of Ultrasound Elastography for Brain Diseases

Liao

Yang

et al. 2020

J of Ultrasound Medicine

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Ultrasound (US) can be used to evaluate the brain structure and nervous system damage. Patients with neurologic symptoms need rapid, noninvasive imaging with high spatial resolution and tissue contrast. Magnetic resonance imaging is currently the most sensitive and specific imaging method for evaluating neuropathologic conditions. This approach does present some challenges, such as the need to transport patients who may be seriously ill to the magnetic resonance imaging suite and the need for patients to remain for a considerable time. Cranial US provides a very valuable imaging method for clinicians, which can make a rapid diagnosis and evaluation without ionizing radiation. The main disadvantage of cranial US is its low sensitivity and specificity for subtle/early lesions. In recent years, with the rapid development of anatomic and functional US technology, the practicability of US diagnosis and intervention has been greatly improved. Ultrasound elastography may have the potential to improve the sensitivity and specificity of various cranial nerve conditions. Ultrasound elastography has received considerable critical attention, and an increasing number of studies have recognized its critical role in evaluating brain diseases. At present, US elastography has been applied to the evaluation of traumatic brain injury, ischemic stroke, intraoperative brain tumors, and hypoxic ischemic encephalopathy. The latest animal experiments and human clinical trial developments in the applications of US elastography for brain diseases are summarized in this review.

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Serial cranial ultrasonography or early MRI for detecting preterm brain injury?

Cited by 74 publications

References 29 publications

T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

T2 Relaxometry MRI Predicts Cerebral Palsy in Preterm Infants

Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

Progress in the Application of Ultrasound Elastography for Brain Diseases

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