Serial FDG-PET Studies in the Prediction of Survival in Patients with Primary Brain Tumors

Schifter, T; Jm, Hoffman; Hanson, Mark D.; Ob, Boyko; Beam, Craig A.; Paine, Susan; Sc, Schold; Pc, Burger; Coleman, RE

doi:10.1097/00004728-199307000-00001

Cited by 81 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the initial description of the use of FDG PET in cerebral gliomas by Di Chiro et al [33], a lot of studies have been performed, and have drawn the same conclusions: There is a clear correlation between the uptake of FDG and the histological grade of gliomas, and also between the uptake of FDG and the survival prognosis [ 11,314,[335][336][337]. The usual visual pattern is a hot spot in high-grade lesions, and a cold spot in low-grade gliomas; however, a cold spot may be seen in some highgrade gliomas; on the other hand, the presence of a hot spot in a low-grade glioma is usually an indicator of malignant degeneration [338].…”

Section: Differential Diagnosis When Lesions Are Demonstratedmentioning

confidence: 99%

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Rigo¹,

Paulus²,

et al. 1996

View full text Add to dashboard Cite

Abstract. Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and followup. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved.

show abstract

Section: Differential Diagnosis When Lesions Are Demonstratedmentioning

confidence: 99%

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Rigo¹,

Paulus²,

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Indeed, Kuesel, et a i,30 suggested that the ap pearance of mobile lipids in regions of viable tumor indi cates metabolic effects of poor perfusion, and neutral lipid droplets were detected in the cytoplasm of hypoxic tumor cells.13 Large amounts of lipids appear to be specific for AA or GBM, but their absence does not rule out AA or GBM, However, it is important to note that histopathological grading is imperfect in its correlation with prognosis. In adults in particular, the clinical course of lower grade tumors, more than half of which recur as, or evolve into, an aggressive phenotype, is difficult to predict.38 There fore, even if !H~MR spectroscopy metabolic characteris tics have limited diagnostic accuracy, they may have prog nostic significance, as has been found in the case of glucose hypermetabolism in PET.1,23,25,44,56 Current issues in the management of patients with AS are whether or not there is an advantage to gross-total resection and whether or not postoperative radiotherapy influences the rate of differentiation or relapse.38 A metabolic characteristic that independently correlates with malignant behavior couid help the clinician to balance the risks and benefits of aggressive therapy more accurately. Because microscopic necrosis in GBM does correlate with prognosis,9,10,41 it is possible that the presence of lipids will also.…”

mentioning

confidence: 99%

Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study

Negendank¹,

Sauter²,

Brown³

et al. 1996

Journal of Neurosurgery

330

201

View full text Add to dashboard Cite

The authors represent a cooperative group of 15 institutions that examined the feasibility of using metabolic fea tures observed in vivo with 'H-magnetic resonance (MR) spectroscopy to characterize brain tumors of the glial type.The institutions provided blinded, centralized MR spectroscopy data processing along with independent central review of MR spectroscopy voxel placement, composition and contamination by brain, histopathological typing using current World Health Organization criteria, and clinical data, Proton 'H-MR spectroscopy was performed using a spin-echo technique to obtain spectra from 8-cc voxels in the tumor and when feasible in the contralateral brain. Eighty-six cases were assessable, 41 of which had contralateral brain spectra. Glial tumors had significantly elevated intensities of choline signals, decreased intensities of creatine signals, and decreased intensities of N-acetyl asp art ate compared to brain. Choline signal intensities were highest in astrocytomas and anaplastic astrocytomas, and creatine signal intensi ties were lowest in glioblastomas. However, whether expressed relative to brain or as intratumoral ratios, these meta bolic characteristics exhibited large variations within each subtype of glial tumor. The resulting overlaps precluded diagnostic accuracy in the distinction of low-and high-grade tumors. Although the extent of contamination of the ]H-MR spectroscopy voxel by brain had a marked effect on metabolite concentrations and ratios, selection of cases with minimal contamination did not reduce these overlaps. Thus, each type and grade of tumor is a metabolically hetero geneous group. Lactate occurred infrequently and in all grades. Mobile lipids, on the other hand, occurred in 41% of high-grade tumors with higher mean amounts found in glioblastomas. This result, coupled with the recent demonstra tion that intratumoral mobile lipids correlate with microscopic tumor cell necrosis, leads to the hypothesis that mobile lipids observed in vivo in E H-MR spectroscopy may correlate independently with prognosis of individual patients. W. G. Negendank, et ciL rylcholine), one primarily from creatines (creatine and phosphocreatine), and one primarily from acetyl aspar tate (NAA), In disease, signals from lactate and mobile lipids may also be observed.Studies of extracts of surgical specimens of human as trocytic tum ors using ]H -N M R spectroscopy indicated an increase in the ratio o f cholines to creatines, and a decrease in the ratio of N A A to creatines, with increas ing histopathological grades of m alignancy.16,45'61 Studies in patients using !H-N M R spectroscopy, referred to as MR spectroscopy, indicated sim ilar correlations betw een m etabolic features in vivo and the histopathological grades of astrocytic tum ors. 4'11'14'21,32,43'57'58'61 Other MR spectroscopy studies indicated that lactate is more likely to be present in high-than in low-grade tumors4, 14,15'20'21 and that the am ount of lactate may correlate with the extent of hyperm etabolic glucose consumption sho...

show abstract

“…Functional imaging using PET is expected to be more sensitive than anatomical imaging such as CT and MRI in detecting abnormalities of the brain; therefore, PET imaging might have a high clinical value in some cases 13) . Several studies have shown high FDG uptake in an abscess 3,4,8,12,15,19,20) . Yamada et al 20) showed that FDG uptake increased in turpentine-induced inflammatory tissue.…”

Section: Resultsmentioning

confidence: 99%

The Role of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Park

Lee

Kang

et al. 2011

J Korean Neurosurg Soc

View full text Add to dashboard Cite

Serial FDG-PET Studies in the Prediction of Survival in Patients with Primary Brain Tumors

Cited by 81 publications

References 0 publications

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study

The Role of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Contact Info

Product

Resources

About

Serial FDG-PET Studies in the Prediction of Survival in Patients with Primary Brain Tumors

Cited by 81 publications

References 0 publications

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study

The Role of18F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Contact Info

Product

Resources

About

The Role of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess