Serial granulocytapheresisunder daily administration of rHuG–CSF: effects on peripheral blood counts, collection efficiency, and yield

Abstract

Repetitive daily rHuG-CSF administration-even under daily leukapheresis procedures-results in a continuing increase in WBC and neutrophil levels and thus leads to increased collection yields. Side effects are tolerable, although Hb and platelet levels should be monitored closely.

Donor tolerance and results of stimulation with G‐CSF alone or in combination with dexamethasone for the collection of granulocytes

“…None of our donors with bone pain required medication. Our data are in line with Worel et al, who reported on mild adverse effects in granulocyte donors under daily administration of G-CSF: bone pain, headache, arthalgia, and myalgia were the most commonly observed side effects (n ¼ 18, 24%), but they were transient [13]. Bux and co-workers also reported on mild side effects in G-CSF stimulated donors but the rate of G-CSF related side effects increased from 58% after the first administration to 63% after the fourth administration [9].…”

Lenograstim with or without dexamethasone for neutrophil mobilization in healthy donors: Short‐term kinetics of white blood cells and effects of granulocyte apheresis

“…Comparable with our findings, several investigators who administered G-CSF at doses of 5, 7.5, or 10 lg/kg reported mild to moderate adverse effects such as bone pain, headache, arthralgia, and myalgia [8][9][10][11][12][13][14][15]29]. The more recent addition of DXM to the G-CSF regimen has resulted in similar symptom complexes with additional side effects, such as insomnia and nausea [5][6][7][8]17,19,28].…”

Granulocyte collection using a novel apheresis system eases the procedure and provides concentrates of high quality

“…Most of our recipients are pediatric patients with a low body weight. Thus, volume reduction is necessary to avoid a transfusion overload in these patients . At our institution a product volume exceeding 500 mL must be divided into two parts before further processing.…”

“…The value of granulocyte transfusions (GTs) in patients with neutropenia with bacterial or fungal infections is still controversial. Although to date the beneficial effect of GT has not been proven in prospective randomized trials, in specific situations GT is an option to treat infections along with antibiotics when there is profound neutropenia . However, prophylactic transfusions are still a matter of discussion .…”