Serial light microscopy of experimental phytophotodermatitis in animal model

Jorge, Valéria Magalhães; Almeida, Hiram Larangeira de; Amado, M.

doi:10.1111/j.1600-0560.2008.01021.x

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…[7] reproduce phytophotodermatitis in animal models by spraying peel juice of Tahiti lemon onto the skin of epilated albino rats and observe its serial pathological changes. After 24 h spongiosis, vacuolization and keratinocyte necrosis are observed, clinically there are no changes.…”

Section: Discussionmentioning

confidence: 99%

Phytophotodermatitis due to chinese herbal medicine decoction

Zhang

Zhu

2011

Indian J Dermatol

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A 24-year-old female presented to the clinic complaining of bizarre patterns and linear streaks of hyperpigmentation on her legs and bizarre alutaceous patches on the neck and upper breast of her son for 7 days. Physical examination showed sharply demarcated hyperpigmented streaks on the extensor aspects of legs and bizarre brown maculae and patches on the right neck and upper chest of her son. Considering the history of Chinese herbal medicine decoction had been splashed onto these sites, phytophotodermatitis was definitely diagnosed.

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Section: Discussionmentioning

confidence: 99%

Phytophotodermatitis due to chinese herbal medicine decoction

Zhang

Zhu

2011

Indian J Dermatol

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“…Phototoxicity and photosensitization studies are presented in Table 12. 25,28,[38][39][40][41][42] No photo irritation was observed in an in vitro study of Citrus Reticulata (Tangerine) Peel Extract (3.0% in formulation). Citrus Auratnium Amara (Bitter Orange) Peel Extract (2.0% in formulation) did not induce photo irritation or photosensitization in guinea pigs.…”

Section: Phototoxicity and Photosensitizationmentioning

confidence: 99%

Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics

Burnett¹,

Bergfeld²,

Belsito³

et al. 2021

Int J Toxicol

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The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 47 Citrus peel-derived ingredients, which are most frequently reported to function in cosmetics as skin conditioning agents. The Panel reviewed the available data to determine the safety of these ingredients. Because final product formulations may contain multiple botanical ingredients, each containing similar constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. Industry should use good manufacturing practices to limit impurities that could be present in botanical ingredients. The Panel concluded that Citrus peel-derived ingredients are safe in the present practices of use and concentration in both rinse-off and leave-on cosmetic products when formulated to be non-sensitizing and non-irritating, provided that leave-on products do not contain more than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).

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“…Animal models are used in experimental studies on phototoxic dermatoses [36][37][38][39][40] , including PPD [41][42][43] , which could be successfully reproduced in rats. PPD was reproduced in the experimental model using only the lemon peel juice, in accordance the results obtained with the experimental studies on humans [32] and consistent with the findings of another study, in which the psoralens in the lemon peel were found in concentrations 13 to 182 higher than in the fruit juice [44] .…”

Section: Discussionmentioning

confidence: 99%

“…The light microscopy revealed an epithelial lesion that appeared in 24 hours, however, the erythema was only clinically evident on the dorsum of the animals after 48 hours ( Figure 4). In a another study, with exposure times ranging from 5 to 8 min, a serial histological study on the epidermal changes immediately after induction was performed: after 1, 2, 4, 6, 24, 48 and 72 h, the left half of each rat was used as the control and was only exposed to sunlight; in another area only peel lemon juice was applied [42] .…”

Section: E X P E R I M E N T a L S T U D I E S O N P P D Reproductionmentioning

confidence: 99%

Phytophotodermatitis: A Review of Its Clinical and Pathogenic Aspects

Almeida

Sartori

Jorge³

et al. 2016

Journal of Dermatological Research

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Phytodermatoses are diseases caused by the contact of human beings with plants. Phytophotodermatitis is a phototoxic reaction entirely independent from the immune system. This reaction occurs when the skin is exposed to photosensitizer substances and to ultraviolet radiation, different from the photoalergic reactions, in which there is an immunologic component. Phytophotodermatitis has a wide range of clinical presentations, the hands are the most common localisation. The Tahiti lemon is the most common cause in Brazil. Experimental researches in animals showed that after 24 hours there are histological changes, characterized by vacuolization and keratinocyte necrosis, which evolves to blister formation after 48 hours, when clinically erythema and blisters could be seen. The initial lesion occurs in the cell membrane and in the desmosomes.

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Serial light microscopy of experimental phytophotodermatitis in animal model

Abstract: PPD can be successfully reproduced in rat skin. After 24 h spongiosis, vacuolization and keratinocyte necrosis are observed, clinically there are no changes. After 48 h, erythema appears with intra- and subepidermal blistering.

Cited by 5 publications

References 13 publications

Phytophotodermatitis due to chinese herbal medicine decoction

Phytophotodermatitis due to chinese herbal medicine decoction

Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics

Phytophotodermatitis: A Review of Its Clinical and Pathogenic Aspects

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