Serial measurements of serum NT-proBNP as markers of left ventricular systolic function and remodeling in children with heart failure

Rusconi, Paolo; Ludwig, David A.; Ratnasamy, Christopher; Mas, R.; Harmon, William G.; Colan, Steven D.; Lipshultz, Steven E.

doi:10.1016/j.ahj.2010.07.012

Cited by 59 publications

(43 citation statements)

References 22 publications

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“…The uniform diagnostic tool for heart failure may have accounted for the similarity in findings. However, unlike other studies (11,17,18) the relationship between plasma NT-proBNP and the severity of heart failure in this study was not uniform as the subjects with moderate heart failure had a lower mean plasma NT-proBNP compared to those with mild heart failure. This may be due to the fact that infants who tend to have higher NT-proBNP values (27) contributed more to subjects with mild and severe forms of heart failure in contrast to those with moderate heart The mortality rate in this study was 3.2% which is lower than the 5.34% reported previously by Sadoh et al (30) in the same study area and 11.1% by Anah and co-workers (5).…”

Section: Discussioncontrasting

confidence: 52%

“…Furthermore, the cut-off values that have been reported have varied widely depending on the study population and the outcome parameter being evaluated. Fonseca et al (16) in a study on the identification of heart failure amongst adults reported a value of 126 pg/mL, Rusconi et al (17) in a study on children with chronic heart failure secondary to dilated cardiomyopathy reported a value of >1,000 pg/mL for the identification of moderate to severe degree of heart failure while Ekure et al (18) gave a cut off of 951 pg/mL for the identification of heart failure in a study on children with structural heart diseases in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Isah

Sadoh

Iduoriyekemwen

2017

Cardiovasc. Diagn. Ther.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Isah

Sadoh

Iduoriyekemwen

2017

Cardiovasc. Diagn. Ther.

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“…The low discrimination power of BNP measurement on admission, as an isolated value, had also been observed by other authors, 34 who reported that serial determinations of NT-proBNP were better prognostic predictors than an isolated measurement. However, other authors have reported an adequate correlation between the measurement of BNP on the first day of life of NBIs with diaphragmatic hernia and their clinical course.…”

Section: Discussionmentioning

confidence: 70%

“…34,35 Likewise, it is necessary to study whether these outcomes are reproducible in other facilities.…”

Section: Discussionmentioning

confidence: 99%

B-type natriuretic peptide: Usefulness in the management of critically-ill neonates

et al. 2017

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B-type natriuretic peptide (BNP) is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life. In the first week of life, BNP levels are high and return to normal with the physiological loss in weight. High BNP levels are associated with different conditions. Objective. To establish the relationship between BNP levels and criticality and the short-term clinical course among patients hospitalized in the neonatal intensive care unit. Method. Observational and analytical study conducted in a prospective cohort. Criticality was defined as a requirement for assisted mechanical ventilation with a fraction of inspired oxygen of more than 50% and/or inotropes. Two blood samples were collected 72 hours apart. Results. Seventy-three patients were included in the study. Depending on their clinical course on day 7, they were divided into 2 groups: patients with a good clinical course or a persistent, severe clinical course. The median baseline BNP level was similar in both groups (p: 0.15). The median BNP level at 72 hours was higher among patients with a persistent, severe clinical course (p: 0.005). The difference between both BNP values was calculated (∆BNP: BNP level at 72 hours -BNP level at 0 hours). The ∆BNP was positive among patients with a persistent, severe clinical course (X= 1260 pg/mL; range: 426-2094) and negative in the group with a good clinical course (X= -967 pg/mL; range: -1656/-278) (p: 0.0002); sensitivity: 87%; specificity: 86%; positive predictive value: 74%; and negative predictive value: 93%. Conclusion. In this group of patients, the delta-BNP value reflected the short-term clinical course.

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“…La poca capacidad discriminativa del dosaje de PNB en el ingreso, como valor aislado, también fue observada por otros autores, 34 quienes reportaron que el valor de NT-pro-PNB en forma seriada era mejor predictor de pronóstico que una única muestra aislada. En cambio, otros autores reportaron buena correlación entre el dosaje de PNB el primer día de vida de niños con hernia diafragmática y su evolución.…”

Section: Discussionunclassified

Péptido natriurético tipo B: utilidad en el manejo de recién nacidos críticamente enfermos

et al. 2017

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RESUMENEl péptido natriurético B (PNB) es un péptido responsable de los cambios durante la organogénesis del corazón y en la transición a la vida extrauterina. En la primera semana de vida, los niveles de PNB son altos y se normalizan con el descenso fisiológico del peso. Valores elevados de PNB se han asociado a diferentes patologías. Objetivo. Establecer la relación entre los niveles de PNB y la criticidad y evolución a corto plazo en pacientes internados en la Unidad de Cuidados Intensivos Neonatales. Método. Estudio observacional analítico de una cohorte prospectiva. Se definió criticidad como requerimientos de asistencia respiratoria con fracción inspirada de oxígeno mayor del 50% y/o inotrópicos. Se extrajeron 2 muestras de sangre con 72 h de diferencia. Resultados. Ingresaron 73 pacientes. Según la evolución al séptimo día del ingreso, se los dividió en 2 grupos: pacientes con buena evolución o con evolución grave persistente. La mediana del PNB inicial fue similar en ambos grupos (p: 0,15). La mediana de PNB a las 72 h fue mayor en los pacientes con evolución grave persistente (p: 0,005). Se calculó la diferencia entre ambos valores de PNB (∆PNB: valor de PNB a las 72 h -valor de PNB a la hora cero). El ∆PNB presentó valores positivos en los pacientes con evolución grave persistente (X= 1260 pg/ml; rango: 426-2094) y valores negativos en el grupo con buena evolución (X= -967 pg/ml; rango: -1656/-278) (p: 0,0002); sensibilidad: 87%; especificidad: 86%; valor predictivo positivo: 74%; y valor predictivo negativo: 93%. Conclusión. En este grupo de pacientes, el delta de PNB reflejó la evolución a corto plazo. Palabras clave: péptido natriurético B, recién nacido.

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Serial measurements of serum NT-proBNP as markers of left ventricular systolic function and remodeling in children with heart failure

Cited by 59 publications

References 22 publications

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

B-type natriuretic peptide: Usefulness in the management of critically-ill neonates

Péptido natriurético tipo B: utilidad en el manejo de recién nacidos críticamente enfermos

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