2019
DOI: 10.1080/01616412.2018.1564187
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Sericin silk protein in peripheral nervous repair associated with the physical exercise of swimming in Wistar rats

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Cited by 8 publications
(7 citation statements)
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“…Despite the negative findings for the exercise protocol proposed, good evolution of the nociceptive threshold and allodynia and for the nerve fiber variables had been shown after swim exercise with overload in sciatic nerve crush model, however the animals swam for 15, 20, and 25 min with an overload of 10% of the BW during 3 weeks (Debastiani et al, 2019), while in the current study the animals swam for an hour with a shorter protocol of 2 weeks. De Moraes et al (2018) used the swimming as a therapeutic alternative for sciatic nerve regeneration.…”
Section: Discussioncontrasting
confidence: 67%
“…Despite the negative findings for the exercise protocol proposed, good evolution of the nociceptive threshold and allodynia and for the nerve fiber variables had been shown after swim exercise with overload in sciatic nerve crush model, however the animals swam for 15, 20, and 25 min with an overload of 10% of the BW during 3 weeks (Debastiani et al, 2019), while in the current study the animals swam for an hour with a shorter protocol of 2 weeks. De Moraes et al (2018) used the swimming as a therapeutic alternative for sciatic nerve regeneration.…”
Section: Discussioncontrasting
confidence: 67%
“…Furthermore, morphological and immunohistochemical measurements demonstrated improvements, including reduction of inflammatory cell infiltration and vacuole formation in injured nerves and decreased expression of SP and IBA1 in spinal dorsal horns corresponding to BPA levels, indicating CWS as a potential therapy for reducing inflammation and pain at early stage of peripheral nerve injury. Many studies reported better functional recovery by cell transplantation, immunotherapy, or nerve transfers when other forms of therapeutic interventions were also applied for management of severe peripheral nerve injury [13][14][15][16]. The present findings evidenced the potential of CWS in enhancing sensory and motor functional recovery, in addition to modulating BPA-induced neuropathic pain.…”
Section: Discussionsupporting
confidence: 59%
“…Moreover, in an in vitro model of traumatic optic neuropathy, electrospun silk fibers loaded with growth factor were reported to promote survival and neurite outgrowth of the retinal ganglion cells (Wittmer et al, 2011). A recent in vivo study has also shown that topical sericin combined with swimming exercise improved sciatic nerve injury in Wistar rats (Debastiani et al, 2019).…”
Section: Neuroregenerationmentioning
confidence: 99%