Series of 12 cases of wheat-dependent exercise-induced allergy in Aragon, Spain

Agulló-García, A.; Saldaña, José Luis Cubero; Sanz, Carlos Colás

doi:10.1016/j.rceng.2018.11.011

Cited by 2 publications

(1 citation statement)

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“…The clinical manifestations of WDEIA include skin symptoms such as urticaria and angio‐oedema, respiratory symptoms such as dyspnoea and brochospasm, gastrointestinal symptoms such as abdominal pain, vomiting or diarrhoea, and CV symptoms such as hypotension, dizziness or even syncope. In the current study, we observed that skin and mucosal tissues (100%) were most frequently involved, while gastrointestinal symptoms were less common (33.3%), which is similar to the previous studies in China, Korea and Spain . We also noted that CV symptoms were more commonly present in East Asian patients (range 84.8–100%) than those in Spain (33.3%); however, large‐scale investigations are required to confirm if this is a true difference.…”

Section: Discussionsupporting

confidence: 89%

Wheat‐dependent exercise‐induced anaphylaxis in Chinese people: a clinical research on 33 cases with antigenic analysis of wheat proteins

et al. 2019

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Background. Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe allergic condition in which wheat ingestion together followed by physical exercise induces anaphylaxis. For patients with WDEIA, omega-5 gliadin is considered to be one of the major allergens. Aim. To analyse the clinical features and allergen spectrum of WDEIA and to investigate the relationship between WDEIA and serum levels of platelet-activating factor (PAF), interleukin (IL)-9 and IL-33. Methods. Medical histories and conditions of WDEIA cases were collected and summarized, with allergen tests of wheat proteins measured at the same visit. Of the 33 patients enrolled, 13 also had serum levels of PAF, IL-9 and IL-33 measured. The healthy control (HC) group consisted of 13 healthy individuals, who also underwent both the wheat-protein allergen tests and the inflammatory-mediator tests. Results. All patients experienced severe allergic reaction during exercise after wheat ingestion. Manifestations of WDEIA included facial oedema, generalized urticaria and respiratory symptoms. Unconsciousness was also observed in 21 cases. In the patient group, 57.6% were confirmed as hypersensitive to glyceraldehyde-3phosphate dehydrogenase (GAPDH), while 54.5% were allergic to omega-5 gliadin. PAF concentration was significantly higher in patients with WDEIA compared with HCs, whereas there was no significant difference in IL-9 or IL-33 between the two groups. Conclusions. WDEIA is a rare type of anaphylaxis. GAPDH and omega-5 gliadin may be the most common allergy-causing wheat proteins for Chinese people. PAF may be associated with the onset and development of WDEIA.

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Section: Discussionsupporting

confidence: 89%