Serious Complications of Topical Mitomycin-C after Pterygium Surgery

Rubinfeld, Roy S.; Pfister, Roswell R.; Stein, Raymond; Foster, C. Stephen; Martin, Michael A.; Stoleru, Samuel; Talley, Audrey R.; Speaker, Mark G.

doi:10.1016/s0161-6420(92)31749-x

Cited by 613 publications

(310 citation statements)

References 14 publications

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“…No entanto, também a introdução de tratamento adjuvante pode estar relacionada a complicações, algumas de significativo grau de severidade (6)(7) .…”

unclassified

Tratamento do pterígio recidivado por transplante autólogo de conjuntiva

Samahá¹,

Schellini²,

Sakamoto³

et al. 2002

Arq. Bras. Oftalmol.

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Objetivo: Avaliar a resposta ao tratamento do pterígio recidivado, usando a técnica do transplante autólogo de conjuntiva. Métodos: Foi realizado estudo retrospectivo de 36 pacientes (36 olhos), portadores de pterígio recidivado, submetidos a transplante autólogo de conjuntiva. O tempo de seguimento mínimo foi de seis meses. Resultados: Observou-se recidiva em 41,6% dos pacientes, perda do enxerto em 5,5% e deiscência de sutura em 2,7%. Conclusões: O transplante de conjuntiva é procedimento com baixo índice de complicações. Porém, quando usado no tratamento do pterígio recidivado, a taxa de recorrência permanece alta. Treatment of recurrent pterygium using conjunctival autograft

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“…No entanto, também a introdução de tratamento adjuvante pode estar relacionada a complicações, algumas de significativo grau de severidade (6)(7) .…”

unclassified

Tratamento do pterígio recidivado por transplante autólogo de conjuntiva

Samahá¹,

Schellini²,

Sakamoto³

et al. 2002

Arq. Bras. Oftalmol.

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“…In such patients the possibility of scleritis, scleral perforations, cataract formation and corneal perforations is high [14].…”

Section: Antimetabolites and Needlingmentioning

confidence: 99%

Needle Revision with Antimetabolites in Bleb Failure

Ghoneim¹

2014

J Clin Res Ophthalmol

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Bleb failure after initially successful glaucoma surgery still constitutes a major challenge in management of glaucoma patients.Needling is considered a simple surgical technique that can solve a major problem like failure of glaucoma surgery.The introduction of antimetabolite in ophthalmology greatly enhances the results of needling as well as the initial trabeculectomy.Mitomycin C(MMC) and 5-Fluorouracil (5FU) used as adjunctive therapy with needling for management of bleb failure with variable success rates but the results with antimetabolites is significantly better than needling alone.In conclusion needling augmented with antimetabolitesis simple technique, relatively safe, fast and has a high success rate, even in complicated glaucoma.

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“…37 Comparative data for beta radiation and mitomycin C are conflicting: a retrospective comparison from Japan suggested that mitomycin C was more effective; a study from Turkey suggested the converse, a Dutch study suggested equivalence; and a randomised controlled study from Australia suggested that beta radiation was more effective than either conjunctival autografting or mitomycin C. [38][39][40][41] While initial reports indicated good safety with mitomycin C, late complications of mitomycin C use, including scleral necrosis and corneal perforation, have been reported that are remarkably similar to those of beta radiation. [42][43][44] Age-related macular degeneration…”

Section: Pterygiummentioning

confidence: 99%

Beta irradiation: new uses for an old treatment: a review

Kirwan¹,

Constable

Murdoch

et al. 2003

Eye

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Beta radiation has a long history as a treatment modality in ophthalmology. It is a convenient and practical method of applying radiation and has the advantage of minimal tissue penetration. There has been a recent resurgence in the use of beta radiation in other areas in medicine, such as the prevention of restenosis after coronary artery stenting. Beta radiation has been shown in vitro and in vivo to inhibit proliferation of human Tenon's fibroblasts, which enter a period of growth arrest but do not die. Effects on the cell cycle controller p53 have been shown to be important in this process.In ophthalmology, beta radiation has been used widely for the treatment of pterygium and is under evaluation for treatment of agerelated macular degeneration and for controlling wound healing after glaucoma drainage surgery. In this latter role, beta radiation may be particularly appropriate for use in developing countries to improve the results of trabeculectomy while potentially avoiding some of the side effects of other antimetabolites.

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Serious Complications of Topical Mitomycin-C after Pterygium Surgery

Cited by 613 publications

References 14 publications

Tratamento do pterígio recidivado por transplante autólogo de conjuntiva

Tratamento do pterígio recidivado por transplante autólogo de conjuntiva

Needle Revision with Antimetabolites in Bleb Failure

Beta irradiation: new uses for an old treatment: a review

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