Sero-epidemiologic and phylogenetic studies of HTLV-I infection in 2 countries of the Caspian Sea region

Senyuta, N. B.; Syrtsev, Alexander; Yamashita, Masahiro; Степина, В Н; Susova, Olga Yu.; Scherbak, Liana; Pavlish, O; Hayami, Masanori; Gurtsevitch, Vladimir

doi:10.1002/(sici)1097-0215(19980812)77:4<488::aid-ijc2>3.0.co;2-q

Cited by 12 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to a previous study, the rate of HTLV-1 infection has been reported to be less than 0.26% in Mashhad, North-Eastern Iran, while it does not exceed 0.34% in other areas of the country [7] . The prevalence of HTLV-1 infection in other countries such as Turkmenistan, Brazil, Spain, Korea and Japan was found to be 0.007% [8] , 1.9% [9] , 0.001% [10] , 0.27% [11] , and 0.12% [12] , respectively. HTLV-1-and HTLV-2-infected carriers remain asymptomatic for a long time, serving as a potential source for the transmission of the disease [13] .…”

Section: Introductionmentioning

confidence: 95%

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014

Salehi¹,

Mostafavi²,

Ghasemian³

et al. 2017

IBJ

View full text Add to dashboard Cite

Background: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. Methods: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions. Results: The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. Conclusion: Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.

show abstract

Section: Introductionmentioning

confidence: 95%

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014

Salehi¹,

Mostafavi²,

Ghasemian³

et al. 2017

IBJ

View full text Add to dashboard Cite

show abstract

“…HTLV‐I infection in neighboring countries include Turkmenistan (northeast of Iran), Kuwait, Saudi Arabia, and Turkey (northwest of Iran) were 0.27%, 0.016%, 0.006%, and 0%, respectively, which indicates a lower prevalence than in Iran.…”

Section: Discussionmentioning

confidence: 96%

Phylogenetic analysis of HTLV‐1 in Iranian blood donors, HIV‐1 positive patients and patients with beta thalassemia

Pirayeshfard

Sharifi

Amini-Kafiabad

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Human T-cell lymphoma virus (HTLV) has been associated with various disease types. Since the discovery of the virus in 1980, seven subtypes of the virus have been identified. HTLV is widespread and endemic in some regions, such as Japan, Africa, South America, and northeast Iran. This study aimed to identify HTLV-1 genotype and also to analyze the nucleotide sequence of the LTR region in three groups, including blood donors, HIV-1+ patients, and β-thalassemia patients. In this cross-sectional study, 2200 samples were collected from blood donors in Tehran (2000 samples), HIV-1+ patients (100 samples) and β-thalassemia patients (100 samples). All samples were screened for anti-HTLV-I&II antibodies by ELISA. Then, genomic DNA was extracted from repeatedly positive samples, and nested PCR was performed for both the TAX and LTR regions. Purified PCR products were sequenced and analyzed, and finally, a phylogenetic tree was constructed using Mega7 software. The prevalence of the anti-HTLV-I&II antibody among blood donors and HIV-1+ patients was 1.7% (34/2000) and 12% (12/100), respectively. The PCR results confirmed that 0.05% (1/2000) of blood donors, 5% (5/100) of HIV-1+ patients, and 8% (8/100) of β-thalassemia patients were HTLV-I positive. All sequences were matched to HTLV-1 subtype a, subgroup A. Our phylogenetic analysis revealed that all sequenced samples belong to the endemic clusters of Iran. HTLV-1 genotypes in all samples were similar in three groups and were derived from the strains, which had been previously reported from Iran (AF00300/Mashhad and KT190712.1/Sabzevar).

show abstract

“…[ 15 ] The prevalence of HTLV-I infection in blood donors in neighboring countries, Turkmenistan (northeast of Iran) and Turkey (northwest of Iran) was 0.27% and 0%, respectively. [ 16 17 ] The prevalence of HTLV-I infection in blood donors in southern neighbors, Saudi Arabia and Kuwait was 0.006% and 0.016%, respectively. [ 18 19 ] The prevalence of HTLV-I infection in Japanese blood donors (1.9%) is higher than in the present study.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of human T-cell lymphotropic virus type-I in blood donors of Northeastern Iran, Sabzevar

Maghsudlu

Safabakhsh

Jamili

2015

Asian J Transfus Sci

View full text Add to dashboard Cite

Background and Objectives:Human T-cell lymphotropic virus type-I (HTLV-I) infection is considered as a public health challenge in endemic areas. The virus is associated with severe diseases, such as adult T-cell leukemia/lymphoma, and HTLV-I-associated myelopathy/tropical spastic paraparesis. One of the major routes of the HTLV-I transmission includes blood transfusion. Sabzevar is located in the endemic region of HTLV-I infection. The aim of the present study was to determine the seroprevalence of HTLV-I infection in the blood donors in Sabzevar.Materials and Methods:A total of 35,067 blood donors in Sabzevar from March 2009 to April 2012 who were screened with HTLV-I on the enzyme-linked immunosorbent assay screening test were included in this survey. Reactive samples that confirmed by western blot were considered to be seropositive cases. The required data were obtained from blood donors’ database of blood transfusion service.Results:The overall prevalence of HTLV-1 based on the positive result of western blot test was 0.14%. The seropositive donors aged 17–59 years with a mean age of 38.10 ± 11.82. The prevalence rates of HTLV-I infection in 3 years of study were 0.19%, 0.14%, and 0.09%, respectively. A significant relation between age, sex, educational level, and history of blood donation was observed with seropositivity of HTLV-I.Conclusion:The improvement of donor selection and laboratory screening caused a decline in the prevalence of infection in blood donors. Given the lower prevalence of infection in regular donors with lower age and higher educational level, more efforts should be done to attract blood donors from these populations.

show abstract

Sero-epidemiologic and phylogenetic studies of HTLV-I infection in 2 countries of the Caspian Sea region

Cited by 12 publications

References 26 publications

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014

Phylogenetic analysis of HTLV‐1 in Iranian blood donors, HIV‐1 positive patients and patients with beta thalassemia

Seroepidemiology of human T-cell lymphotropic virus type-I in blood donors of Northeastern Iran, Sabzevar

Contact Info

Product

Resources

About