Serodiagnosis of Acute Viral Hepatitis

Hoofnagle, H.

doi:10.1002/hep.1840030222

Cited by 29 publications

(3 citation statements)

References 9 publications

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“…Acute infection caused by HAV and HBV is accompanied by biochemical evidence of liver injury. In acute symptomatic hepatitis, trasnaminase tests are markedly elevated (3,4). The concentrations of other enzymes such as lactic dehydrogenase (LD) and alkaline phosphatase (ALP) are usually only mildly increased.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis A and B Discrimination According to Aminotransferases

Parlakay¹,

Kara²,

Devrim³

et al. 2011

Çocuk Enf Derg

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Objective: Acute infection of hepatitis A and B viruses is accompanied by biochemical evidence of liver injury. In acute symptomatic hepatitis, transaminase tests are markedly elevated, especially, in hepatitis A. This study was carried out to examine the feasibility of discrimination between hepatitis A and B in acute phase using serum transaminase concentrations so as to take isolation precautions and to plan supportive therapy in early phase. Methods: Between January 1996 and December 1998, 444 patients, [239 (53.8%) males and 205 (46.2%) females] are tested for hepatitis B surface antigen (HBsAg), hepatitis B core IgM antigen (anti-HBc IgM), and hepatitis A immunglobuline M (anti-HAV IgM), alanine aminotransferase (ALT), aspartat aminotransferase (AST) and bilirubin concentrations and comparison of transaminase concentrations between patients infected with hepatitis A and hepatitis B has been made. Results: ALT concentrations of HAV-infected patients had a median of 879 (minimum: 4, maximum: 7201), whereas HBV-infected patients had a median of 66 (minimum: 16, maximum: 3118). AST concentrations of HAV-infected patients had a median of 492 (minimum: 8, maximum: 5718), whereas HBV-infected patients had a median of 59,5 (minimum: 13, maximum: 2040). Transaminase concentrations of patients infected with hepatitis A are higher than patients infected with hepatitis B (for ALT and AST p<0,001). Also there was difference in transaminase concentration in acute hepatitis with age. Concentrations of serum transaminases in acute hepatitis increased with age and peaked at 7-8 years, having a median of 1565 (minimum: 9 and maximum: 4014) for AST and 1942 (minimum: 22 and maximum: 3950) for ALT. Conclusion: Discrimination between hepatitis A and B in acute phase using serum transaminase concentrations could be helpful to get isolation precautions and to plan supportive therapy in early phase. (J Pediatr Inf 2011; 5: 1-3)

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Section: Discussionmentioning

confidence: 99%

Hepatitis A and B Discrimination According to Aminotransferases

Parlakay¹,

Kara²,

Devrim³

et al. 2011

Çocuk Enf Derg

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“…Nessa modalidade da doença, os indivíduos acometidos exibem altos títulos do anti-HBc IgM no soro (SANCHEZ-TAPIAS et al, 1987;HOOFNAGLE;DI BISCEGLIE, 1991).…”

Section: Mecanismos De Transmissãounclassified

Soroprevalência da infecção pelos vírus da hepatite B e D em dois municípios da região do Baixo Munim, Maranhão, Brasil

Silva¹

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“…Os achados sorológicos variam nas fases de evolução da doença, e a dinâmica da presença dos marcadores reflete a replicação do vírus e a resposta imune dos infectados (Hoofnagle, 1983). Em indivíduos recentemente infectados, o antígeno de superfície (HBsAg) é o primeiro marcador sorológico a surgir, sendo detectável durante o período de incubação, cerca de duas a sete semanas antes dos sintomas, persistindo por um período de até 180 dias, desaparecendo cerca de quatro a cinco meses após a exposição (da Silva et al,…”

Section: Diagnósticounclassified

Expressão de antígenos virais fusionados a uma proteína formadora de corpos de oclusão de um vírus de inseto

Silva¹

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Serodiagnosis of Acute Viral Hepatitis

Cited by 29 publications

References 9 publications

Hepatitis A and B Discrimination According to Aminotransferases

Hepatitis A and B Discrimination According to Aminotransferases

Soroprevalência da infecção pelos vírus da hepatite B e D em dois municípios da região do Baixo Munim, Maranhão, Brasil

Expressão de antígenos virais fusionados a uma proteína formadora de corpos de oclusão de um vírus de inseto

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