Serodiagnostic Performance of Resat-6-CFP-10 in the Diagnosis of Pulmonary Tuberculosis in Ethiopia

Belay, Mulugeta; Bjune, Gunnar; Amen, Gobena

doi:10.4172/2161-1068.1000103

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The study area has been described elsewhere [ 14 ]. Briefly, the study was conducted in two public (Awash Health Centre and Dubti Hospital) health facilities in Afar region and three private (Selam hospital, Bati Hospital, and Amir Higher Clinic) health facilities in Dessie town.…”

Section: Methodsmentioning

confidence: 99%

Strain Diversity ofMycobacterium tuberculosisIsolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia

Belay

Ameni

Bjune

et al. 2014

BioMed Research International

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Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tuberculosis is the second leading cause of mortality. Culture of sputum samples collected from a total of 325 pulmonary TB suspects was done to isolate MTBC. Spoligotyping was used to characterize 105 isolates from culture positive slopes and the result was compared with an international database. Forty-four spoligotype patterns were observed to correspond to 35 shared-types (SITs) containing 96 isolates and 9 orphan patterns; 27 SITs containing 83 isolates matched a preexisting shared-type in the database, whereas 8 SITs (n = 13 isolates) were newly created. A total of 19 SITs containing 80 isolates were clustered within this study (overall clustering of 76.19%). Three dominant lineages (T, CAS, and Manu) accounted for 76.19% of the isolates. SIT149/T3-ETH was one of the two most dominant sublineages. Unlike previous reports, we show that Manu lineage strains not only constitute a dominant lineage, but are also associated with HIV infection in Afar region of Ethiopia. The high level of clustering suggests the presence of recent transmission that should be further studied using additional genotyping markers.

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Section: Methodsmentioning

confidence: 99%

Strain Diversity ofMycobacterium tuberculosisIsolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia

Belay

Ameni

Bjune

et al. 2014

BioMed Research International

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“…The immune system forms a scar tissue around the TB bacteria which isolate it from rest of the body. Tuberculosis that occurs after initial exposure to the bacteria is often referred to as primary TB [17]. If the person's body is able to form a scar tissue (fibrosis) around the TB bacteria, inside the body then the infection is contained in an inactive state.…”

Section: Immune Response Against Tbmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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“…7 Di Asia Afrika ditemukan kasus TB Paru 2 kali lebih besar dari Asia Tenggara yaitu 350 per 100.000 penduduk. 9 Diperkirakan angka kematian akibat TB Paru adalah 8.000 setiap hari dan 2,3 juta setiap bulan. Laporan WHO tahun 2004 menyebutkan bahwa jumlah terbesar kematian akibat TB Paru terdapat di Asia Tenggara yaitu 625.000 orang.…”

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Hubungan pemberian imunisasi BCG dengan kejadian TB paru pada anak di Puskesmas Tuminting periode Januari 2012 – Juni 2012

Susanto¹,

Wahani²,

Rompis³

2016

eCl

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Pulmonary Tuberculosis (Tb) is still a public health problem. The prevalence of pulmonary Tb from year to year in Manado is still high even though the management of strategy is relatively the same- prevention by immunization, case finding, and treatment strategy with supervision and with DOT directly. Prevention with immunization results in better body resistance. Immunization against Tb is required in some countries and is recommended in several other countries. Although the majority of toddlers are already BCG vaccinated there are still many pulmonary Tb cases among children in Manado. This study aimed to obtain the relationship between the BCG immunization and pulmonary TB occurence in children in Tuminting Primary Health Care, Manado. The results showed that at Tuminting Primary Health Care most of the toddlers had been BCG immunized. Tuberculosis was found among toddlers aged >3 years and there was a significant correlation between BCG immunization and the occurence of tuberculosis with an OR 0.804. Keywords: immunization BCG, occurence of TB Abstrak: Penyakit TB paru sampai saat ini masih menjadi masalah kesehatan masyarakat. Prevalensi TB paru dari tahun ke tahun di Kota Manado tetap tinggi meskipun strategi penanganan yang diterapkan relative sama, yaitu pencegahan dengan imunisasi. penemuan penderita, dan pengobatan dengan strategi DOT atau dengan pengawasan minum obat secara langsung. Pencegahan dengan imunisasi merupakan tindakan yang mengakibatkan seseorang mempunyai ketahanan tubuh yang lebih baik. Imunisasi terhadap penyakit TB telah diwajibkan di beberapa negara serta direkomendasikan di beberapa negara lainnya. Penyakit TB banyak terjadi pada anak di Kota Manado padahal anak balita tersebut sebagian besar sudah divaksinasi BCG. Penelitian ini bertujuan untuk mengetahui hubungan antara pemberian imunisasi BCG dengan kejadian TB Paru pada anak di Puskesmas Tuminting Manado. Hasil penelitian memperlihatkan bahwa sebagian besar anak balita yang berobat di Puskesmas Tuminting telah diberikan imunisasi BCG. Kejadian tuberkulosis ditemukan pada umur >3 tahun dan terdapat hubungan bermakna antara pemberian imunisasi BCG dengan kejadian tuberkulosis paru dengan nilai OR 0,804.Kata kunci: imunisasi BCG, kejadian TB paru

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Serodiagnostic Performance of Resat-6-CFP-10 in the Diagnosis of Pulmonary Tuberculosis in Ethiopia

Abstract: Background: Tuberculosis (TB) is a major public health problem globally. Lack of rapid and accurate diagnostic tests remain an obstacle for effective control. The aim of this study was to evaluate the potential of rESAT-6-CFP-10 in detecting active pulmonary TB in a high burden setting.

Cited by 3 publications

References 17 publications

Strain Diversity ofMycobacterium tuberculosisIsolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia

Strain Diversity ofMycobacterium tuberculosisIsolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia

Role of Diabetes in prevalence of Tuberculosis

Hubungan pemberian imunisasi BCG dengan kejadian TB paru pada anak di Puskesmas Tuminting periode Januari 2012 – Juni 2012

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