Seroepidemiology of Cytomegalovirus Infection in Pregnant Women in the Central Mexican City of Aguascalientes

Alvarado‐Esquivel, Cosme; Terrones-Saldívar, María del Carmen; Hernández‐Tinoco, Jesús; Munoz-Terrones, Maria Daniela Enriqueta; Gallegos-González, Roberto Oswaldo; Sánchez‐Anguiano, Luis Francisco; Reyes-Robles, Martha Elena; Antuna-Salcido, Elizabeth Irasema

doi:10.14740/jocmr3358w

Cited by 9 publications

(19 citation statements)

References 29 publications

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“…Anti-cytomegalovirus antibodies can be detected in 86% to 96% of the general population and in about 95% of pregnant women. 14 Most individuals have latent infections. When immunity is diminished in pregnant women, latent infections can become virulent and be transmitted to the newborn through milk.…”

Section: Discussionmentioning

confidence: 99%

Analysis of common causes of liver damage among children 12 years and younger in Weifang

Meng

Yuan

et al. 2021

J Int Med Res

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Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most common causes of infectious liver damage were viral infection (1515 cases), Mycoplasma pneumoniae infection (343 cases), and bacterial infection (197 cases). The most common causes of viral liver damage were Epstein–Barr virus, cytomegalovirus, and enterovirus. The most common causes of non-infectious liver damage were drug-induced liver damage, Kawasaki disease, and genetic metabolic diseases. There were 31 cases of severe liver damage. Conclusion There were many causes of liver damage among children in Weifang. Infections, and especially viral infections such as Epstein–Barr virus, were the most common causes of liver damage. Severe liver damage was primarily caused by drugs or poisons.

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Section: Discussionmentioning

confidence: 99%

Analysis of common causes of liver damage among children 12 years and younger in Weifang

Meng

Yuan

et al. 2021

J Int Med Res

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“…Seroprevalence among women of reproductive age suggests a potential increase with age; however, these findings are limited by the small dataset. Seroprevalence of CMV infection in pregnant women in Mexico was higher in those aged 20 to 30 years than those aged ≤ 20 years (91.3 vs 86.5%, respectively) [ 44 ]. Studies from Canada and the United States indicate that seroprevalence was higher among women aged > 40 years compared with women aged ≤ 40 years [ 45 – 47 ].…”

Section: Seroprevalence By Sex and Age Groupmentioning

confidence: 99%

A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development

Fowler

Mucha²,

Neumann³

et al. 2022

BMC Public Health

112

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Background Cytomegalovirus (CMV) is a common pathogen that affects individuals of all ages and establishes lifelong latency. Although CMV is typically asymptomatic in healthy individuals, infection during pregnancy or in immunocompromised individuals can cause severe disease. Currently, treatments are limited, with no prophylactic vaccine available. Knowledge of the current epidemiologic burden of CMV is necessary to understand the need for treatment and prevention. A systematic literature review (SLR) was conducted to describe the most recent epidemiologic burden of CMV globally. Methods Medline, Embase, and LILACS were searched to identify data on CMV prevalence, seroprevalence, shedding, and transmission rates. The SLR covered the time period of 2010–2020 and focused geographically on Australia, Europe, Israel, Japan, Latin America (LATAM), and North America. Studies were excluded if they were systematic or narrative reviews, abstracts, case series, letters, or correspondence. Studies with sample sizes < 100 were excluded to focus on studies with higher quality of data. Results Twenty-nine studies were included. Among adult men, CMV immunoglobulin G (IgG) seroprevalence ranged from 39.3% (France) to 48.0% (United States). Among women of reproductive age in Europe, Japan, LATAM, and North America, CMV IgG seroprevalence was 45.6-95.7%, 60.2%, 58.3-94.5%, and 24.6-81.0%, respectively. Seroprevalence increased with age and was lower in developed than developing countries, but data were limited. No studies of CMV immunoglobulin M (IgM) seroprevalence among men were identified. Among women of reproductive age, CMV IgM seroprevalence was heterogenous across Europe (1.0-4.6%), North America (2.3-4.5%), Japan (0.8%), and LATAM (0-0.7%). CMV seroprevalence correlated with race, ethnicity, socioeconomic status, and education level. CMV shedding ranged between 0% and 70.2% depending on age group. No findings on CMV transmission rates were identified. Conclusions Certain populations and regions are at a substantially higher risk of CMV infection. The extensive epidemiologic burden of CMV calls for increased efforts in the research and development of vaccines and treatments. Trial registration N/A.

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“…Also, in the study conducted by Mamuye et al (10), there was no significant correlation between seropositivity to CMV and education, employment, gestation age and parity. In in the research from Mexico, no socio-demographic characteristics of pregnant women including age, ethnic group, place of birth, housing, place of work, education level, low socioeconomic status were associated (P> 0.05) with seropositivity to CMV (27). While a study in Tanzania proved that older age, multiparity, and low socioeconomic status were significantly associated with CMV IgG seroprevalence (p <0.01) (33).…”

Section: Discussionmentioning

confidence: 85%

Cytomegalovirus Infection in Pregnancy - Our Experiences

et al. 2019

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Introduction: Cytomegalovirus (CMV) infection is ubiquitous. It affects all age groups, and its clinical picture ranges from mild to severe, especially as a congenital infection in neonates. Aim: To determine frequency of CMV infection in pregnant women in Tuzla Canton (TC) and the risk factors that lead to the infection. Methods: This prospective study included 300 pregnant women from TC aged 18 to 42 years. CMV serology was performed on all participants, and in case of acute infection additionally IgG avidity test. Participants also completed the questionnaire on the risk factors for CMV infection. Results: The median age of the 300 women was 28 ±4.97 years. There were 161participants (53.6%) who classified their environment as urban and 295 (98.33%) were married. More than half of the women had completed secondary school 168 (56%). Positive IgG antibodies to CMV had 280 (93.0%) women. Positive IgM and IgG antibodies had 9 (3.0%) participants, but all of them had high IgG avidity, which indicates reinfection or recurrent CMV infection. There was a statistically significant higher number of seropositive participants living in rural areas than those living in urban areas (p= 0.048). Also, there was significantly higher percentage of positive anti-CMV IgG in pregnant women with lower education (p=0.04). Conclusion: In our region there is high seropositivity rates of IgG antibodies to CMV in pregnant women. No case of primary CMV infection was proven. The risk factors for CMV infection have been proven to be rural environment and lower level of education.

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Seroepidemiology of Cytomegalovirus Infection in Pregnant Women in the Central Mexican City of Aguascalientes

Cited by 9 publications

References 29 publications

Analysis of common causes of liver damage among children 12 years and younger in Weifang

Analysis of common causes of liver damage among children 12 years and younger in Weifang

A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development

Cytomegalovirus Infection in Pregnancy - Our Experiences

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