Seroepidemiology of hepatitis A antibodies among children’s hospital staff

Livni, Gilat; Plotkin, Simion; Yuhas, Yael; Chodik, Gabriel; Aloni, Hava; Lerman, Yehuda; Ashkenazi, Shai

doi:10.1097/00006454-200207000-00003

Cited by 13 publications

(6 citation statements)

References 20 publications

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“…Additionally, the sero-prevalence of HAV was not significantly different in females (71.5%) and males (70%). These results are in agreement with some studies ( 17 , 18 ) but are in contrast with others indicating that sero-prevalence rate is higher in male ( 15 ). Also, this study did not find statistic differences between the HAV seropositivity rate in cases working at infectious disease or gastrointestinal wards with other wards.…”

Section: Discussionsupporting

confidence: 93%

Hepatitis A Virus Seropositivity in Nurses and Paramedical Personnel at a University Hospital in North Iran

Bayani

Sadeghi

Kalantari

et al. 2013

Iran Red Crescent Med J

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BackgroundThe status of hepatitis A virus (HAV) among health care workers has not been studied yet in Iran.ObjectivesThis study aimed to evaluate the HAV seropositivity among the healthcare personnel in Ayatollah Rohani Hospital, Babol, Iran, according to age, number of working years, and other demographic data.Patients and MethodsThis cross sectional study was performed on all nurses, nurses' aid, and paramedical technicians at Ayatollah Rohani Hospital, Babol, from March 2011 to March 2012. Blood was obtained from all cases (466) and the sera were separated. All serum samples were tested for anti-HAV antibodies (IgG) by enzyme-linked immunosorbent assay (ELISA). Data were analyzed by logistic regression analysis using SPSS software, version 18.Results330 out of 466 (71%) persons were positive for anti-HAV antibodies (IgG) with no significant difference between females (71.5%) and males (70%) (P = 0.89, 95% CI. 0.533-2.083). The lowest sero-prevalence rate was observed in the 20-29 year age group (57.8%). Seropositivity for HAV significantly increased with age (P < 0.000, 95% CI. 1.626-3.262), 77.4% for 30-39 years and 85.3% for more than 40 years. The seropositivity rate also increased significantly in accordance with the number of working years (P = 0.012, 95%CI. 1.098-2.170). 110 out of 353 (31.2%) cases were seronegative among those with less than 5 years of working time. An obvious decrease of seronegative rate of HAV was seen in those with 5-10 years (27%) and more than 10 years (14.3%) of working time.ConclusionsThese findings indicate relatively high prevalence rate of HA infection among nurses and paramedical personnel at this hospital. Nevertheless, 30% of the health workers have been seronegative and are still at risk of HA infection development. Considering that the disease has more severe course as age increases, improvement of standard hygiene and prevention strategies are recommended. Furthermore, vaccination may play a significant role in the occupational health policy to protect the susceptible health care workers population in the future.

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Section: Discussionsupporting

confidence: 93%

Hepatitis A Virus Seropositivity in Nurses and Paramedical Personnel at a University Hospital in North Iran

Bayani

Sadeghi

Kalantari

et al. 2013

Iran Red Crescent Med J

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“…For employers, HA in the adult working population is connected with absenteeism [12,13]. Immunity against HAV infection among working professional aged 25-64 may be of concern for employers.…”

Section: Discussionmentioning

confidence: 99%

Immunity to hepatitis A virus among working professionals in Poland – Results of a 3-year serological survey 2013–2015

Juszczyk¹,

Czerw

Walewska-Zielecka³

et al. 2018

Ann Agric Environ Med.

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Introduction. Hepatitis A (HA) is caused by infection with the hepatitis A virus (HAV). The differential etiological diagnosis of acute hepatitis is based on a positive result of the serological test detecting IgM class anti-HAV. For epidemiological studies on past infection and seroprevalence of HAV in populations, the tests measuring IgG class anti-HAV or total anti-HAV are used. Since the 1990s, specific prophylaxis is possible by vaccination against HA. In Poland, vaccination is recommended and in majority is performed at own cost. Materials and method. Database was obtained from electronic medical records of the 2 major private health care providers networks (Luxmed and Medicover) operating in Poland. During a 3-year period (2013-2015), 1,124 persons with unknown status of anti-HA vaccination were tested for the presence of total anti-HAV. Objective. The aim of the study was to evaluate the seroprevalence of anti-HAV among working professionals in Poland. Results. Anti-HAV were detected in 603 (53.6%) persons, while 521 (46.3%) tested negative. The study group was divided into 2 subgroups: 25-44 and 45-64-years-old. For detailed statistical analysis, the presence of anti-HAV was considered as a dependent variable, and its predictors were gender, age and the year of the test performance. The presence of anti-HAV was significantly more prevalent in older age group. The lack of specific antibodies was more prevalent in younger age group. Conclusions. Results of the study show increasing susceptibility to HAV infection in the younger age group, compared with the older age group of corporate professional employees in large cities in Poland. Since the epidemiological situation of HA is currently changing with increasing number of symptomatic cases of HA, it is suggested that employers might consider including an additional procedure of vaccination against HA into their private health insurance portfolio.

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“…HAV and HEV are among the causative agents of acute hepatitis and global health problems in developed and developing countries ( 10 , 11 ). In endemic regions, over 80% of the population carry anti-HAV antibodies, whereas the level of anti-HEV antibodies is lower in the same population ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis A and E Virus Infections Among Healthy Population in Shiraz, Southern Iran

Asaei

Ziyaeyan

Moeini

et al. 2015

Jundishapur J Microbiol

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Background:Enterically-transmitted acute viral hepatitis is caused predominantly by hepatitis A virus (HAV) and hepatitis E virus (HEV). The prevalence of HEV and HAV infections varies in different geographical regions.Objectives:This study was conducted to determine the prevalence of HEV and HAV infections among Iranian healthy individuals in southern Iran.Patients and Methods:Totally, 1030 samples were collected from healthy subjects in schools, those referred to tertiary outpatient clinics and health centers in Shiraz between November 2011 and May 2012. Their ages ranged between six months and 95 years. The presence of total anti-HAV and anti-HEV immunoglobulin M (IgM) in plasma was assessed by ELISA.Results:The results showed that 66.2% and 0.6% of the general population in this area were positive for total anti-HAV and IgM antibodies by ELISA, respectively. As seen, 13.4% and 0.9% were positive for total anti-HEV and IgM antibodies, respectively. The difference in total anti-HAV and anti-HEV antibodies was significant among the age groups (P < 0.001).Conclusions:This study showed that the prevalence rates of HAV and HEV antibodies were positively correlated with age. The results demonstrated that the infection with these two viruses in the region was high and some high-risk individuals including females at child-bearing age were more susceptible. HAV vaccination could be recommended for antibody-negative adults.

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Seroepidemiology of hepatitis A antibodies among children’s hospital staff

Abstract: HAV seropositivity was associated mainly with sociodemographic variables. Most children's hospital employees, especially pediatricians and other young (<40 years) employees, are seronegative and therefore susceptible to HAV. Vaccination of the high risk groups should be considered.

Cited by 13 publications

References 20 publications

Hepatitis A Virus Seropositivity in Nurses and Paramedical Personnel at a University Hospital in North Iran

Hepatitis A Virus Seropositivity in Nurses and Paramedical Personnel at a University Hospital in North Iran

Immunity to hepatitis A virus among working professionals in Poland – Results of a 3-year serological survey 2013–2015

Seroprevalence of Hepatitis A and E Virus Infections Among Healthy Population in Shiraz, Southern Iran

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