Serologic and Epidemiologic Evidence of Infection in Turkeys with an Agent Related to the Swine Influenza Virus

Mohan, Ram; Ym, Saif; Erickson, G. A.; Gustafson, G A; Easterday, B. C.

doi:10.2307/1589822

Cited by 57 publications

(26 citation statements)

References 2 publications

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“…Regarding the PVA, attachment of the human-origin H1N1 virus was observed in the respiratory (nasal cavity and lung) and intestinal tracts, while the attachment of the avian-origin H4N5 virus was restricted to the respiratory tract. This was consistent with the fact that turkeys are also susceptible to swine-origin H1N1 and H3N2 influenza viruses [37-41], to reassortant viruses with human, swine, and avian influenza genes (H1N2) [42,43], as well as to the pH1N1 virus, as demonstrated in August 2009 in two turkey flocks naturally infected in Chile [44], indicating the potential of avian species that express both α-2,3 and α-2,6 receptors, to be susceptible to mammal-origin influenza viruses and potentially offer an adequate environment for the emergence of reassortant viruses. Turkeys have also been successfully infected with the pH1N1 virus by experimental inoculation via the intrauterine route, with subsequent oropharyngeal and cloacal virus shedding, but were not infected when the intranasal route was used [45].…”

Section: Discussionsupporting

confidence: 83%

Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species

Costa

Chaves

Valle

et al. 2012

Vet Res

107

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This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant, ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6 receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general, in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various avian species might reflect a potentially decisive factor in the emergence of new viral strains.

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Section: Discussionsupporting

confidence: 83%

Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species

Costa

Chaves

Valle

et al. 2012

Vet Res

107

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“…Many researchers have suggested that the H1 influenza virus can be transmitted across hosts from birds to mammals and that it poses a threat to public health. Similarly, reverse transmission of the influenza virus from mammals to birds has also been reported [2, 3]. Three human epidemics have been attributed to H1N1, and these epidemics were accompanied by significant loss of life.…”

Section: Introductionmentioning

confidence: 92%

Epidemic of wild-origin H1NX avian influenza viruses in Anhui, China

Yao

Wang

et al. 2017

Infect Dis Poverty

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BackgroundAs the natural hosts of avian influenza viruses (AIVs), aquatic and migratory birds provide a gene pool for genetic transfer among species and across species, forming transient “genome constellations.” This work describes the phylogenetic dynamics of H1NX based on the complete molecular characterization of eight genes of viruses that were collected from 2014 to 2015 in Anhui Province, China.MethodsHemagglutination and hemagglutination inhibition tests were used to determine the hemagglutination (HA) activity of the HA subtypes. The entire genomes of the viruses were sequenced on an ABI PRISM 3500xl DNA Analyzer. The sequences were genetically analysed to study their genetic evolution using DNASTAR and MEGA 6. The pathogenic effects of the viruses were evaluated using mouse infection models.ResultsSeven strains of the H1 subtype avian influenza virus were isolated. Phylogenetic analysis indicated natural recombination of the H1 influenza viruses between the Eurasian lineage and the North American lineage. Some genes had high sequence identity with A/bean goose/Korea/220/2011(H9N2), which is a typical case involving viral reassortment between the Eurasian lineage and the North American lineage. The results of infection experiments in mice showed that the viruses could acquire the ability to multiply in mouse respiratory organs without adaptation.ConclusionsThese findings suggest that continued surveillance of wild birds, particularly migratory birds, is important to provide early warning of possible H1 influenza epidemics and to understand the ecology of the virus.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0304-4) contains supplementary material, which is available to authorized users.

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“…The introduction of classical swine H1N1 influenza viruses to turkeys from infected pigs has been reported to occur regularly in the USA, and in some cases, influenza-like illness in pigs has been followed immediately by disease signs in turkeys (Halvorson et al 1992;Mohan et al 1981;Pomeroy 1982). Genetic studies of H1N1 viruses from turkeys in the USA has revealed a high degree of genetic exchange and reassortment of influenza A viruses from turkeys and pigs in the former species (Wright et al 1992).…”

Section: Pigsmentioning

confidence: 99%

Animal and Human Health Implications of Avian Influenza Infections

Capua

Alexander

2007

Bioscience Reports

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Avian influenza (AI) is a listed disease of the World Organisation for Animal Health (OIE) that has become a disease of great importance both for animal and human health. Until recent times, AI was considered a disease of birds with zoonotic implications of limited significance. The emergence and spread of the Asian lineage highly pathogenic AI (HPAI) H5N1 virus has dramatically changed this perspective; not only has it been responsible of the death or culling of millions of birds, but this virus has also been able to infect a variety of non-avian hosts including human beings. The implications of such a panzootic reflect themselves in animal health issues, notably in the reduction of a protein source for developing countries and in the management of the pandemic potential. Retrospective studies have shown that avian progenitors play an important role in the generation of pandemic viruses for humans, and therefore these infections in the avian reservoir should be subjected to control measures aiming at eradication of the Asian H5N1 virus from all sectors rather than just eliminating or reducing the impact of the disease in poultry.

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Serologic and Epidemiologic Evidence of Infection in Turkeys with an Agent Related to the Swine Influenza Virus

Cited by 57 publications

References 2 publications

Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species

Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species

Epidemic of wild-origin H1NX avian influenza viruses in Anhui, China

Animal and Human Health Implications of Avian Influenza Infections

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