Serologic Evidence of Hantavirus Infection in Humans, Colombia

Máttar, Salim; Parra, Miguel Ramos

doi:10.3201/eid1012.040821

Cited by 36 publications

(27 citation statements)

References 7 publications

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“…However, all the positive samples in this work were rural workers. This finding is similar to a serum prevalence study conducted in Colombia, where all positive samples came from men involved in agricultural activities 23 .…”

Section: Conflict Of Interest Referencessupporting

confidence: 78%

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Souza

Machado

Figueiredo

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: According to reports by the Ministry of Health, in the far western region of the State of Santa Catarina, there have been no reports of hantavirus pulmonary syndrome, a zoonotic disease transmitted by feces of infected rodents. A seroepidemiological study of residents of this region, was conducted, with the aim of determining the presence of hantavirus infections. A total of 340 volunteers of both genus, from the towns of Belmonte and Paraíso, were studied. Methods: The serum of these patients was collected and used to detect IgG antibodies against recombinant N protein of Araraquara hantavirus, by ELISA assay. The positive samples were then titrated and confirmed by immunofluorescence assay. Results: This study demonstrated the presence of IgG antibodies against hantavirus N protein in 3.5% of the population. The most frequent occupation was farm worker, 81% had direct and indirect contact with rodents, 91.7% of positive cases were farm workers, indicating that the probable cause of infection occurred during barn cleaning. These antibodies are noteworthy, given that the levels of antibodies were verified in individuals whose contact with hantavirus may have occurred many years ago. Conclusions: This study shows the circulation of hantavirus in the region, a fact that until now, had not reported. All the serum reagents had contact with the pathogen, but did not develop pulmonary and cardiovascular syndrome. It is important to remain alert, because hantavirus is a serious and emerging disease of some relevance. Keywords: Hantavirus. Seroprevalence in Santa Catarina. Morbidity. RESUMO Introdução:De acordo com relatórios do Ministério da Saúde, na região do extremo oeste do Estado de Santa Catarina, não há relatos de síndrome pulmonar por hantavírus, doença zoonótica transmitida por excretas de roedores contaminados. Com a finalidade de demosntrar a infecção por hantavírus, um estudo soroepidemiológico de moradores da região foi realizado. Assim, foi estudado um total de 340 voluntários de ambos os gêneros, dos municípios de Belmonte e Paraíso. Métodos: O soro destes pacientes foi coletado e usado para a detecção de anticorpos IgG contra a proteína N recombinante de hantavírus Araraquara, pelo teste de ELISA. As amostras positivas foram tituladas e confirmadas por imunofluorescência indireta. Resultados: Este estudo demonstrou a presença de anticorpos IgG contra a proteína N hantavírus em 3,5% da população. A ocupação de lavrador foi a mais frequente, e 81% tiveram contato direto e indireto com os roedores, 91,7% dos casos positivos foram os agricultores, a causa provável da infecção foi através da limpeza de celeiros. Estes anticorpos são notáveis, dado que os níveis de anticorpos são encontrados nos indivíduos cujo contato com o hantavírus pode ter ocorrido há muitos anos. Conclusões: Este estudo mostra a circulação de hantavírus na região, um fato que até então não havia relatado, todos os reagentes soro tiveram contato com o patógeno, mas não desenvolveram a síndrome pulmonar e cardiovascu...

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Section: Conflict Of Interest Referencessupporting

confidence: 78%

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Souza

Machado

Figueiredo

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…As we have demonstrated, the ARAV antigen-based ELISA appears to be a sensitive test for detecting human exposure to hantaviruses in northwestern Colombia. Mattar and Parra (2004) reported a 13.5% infection prevalence rate in humans using an ELISA based on a recombinant nucleocapsid protein antigen of SNV. Our prevalence rate obtained using MACV and ARAV antigens was 8.39%, which is similar to that reported by Mattar and Parra (2004).…”

Section: Discussionmentioning

confidence: 99%

“…Mattar and Parra (2004) reported a 13.5% infection prevalence rate in humans using an ELISA based on a recombinant nucleocapsid protein antigen of SNV. Our prevalence rate obtained using MACV and ARAV antigens was 8.39%, which is similar to that reported by Mattar and Parra (2004). Our results indicate that tests conducted with South American hantavirus antigens could have predictive value and could represent a useful alternative for the diagnosis of hantavirus infection in Colombia.…”

Section: Discussionmentioning

confidence: 99%

“…Our study included the municipalities of Planeta Rica (8º4'33.26"N 75º35'11.47"W), Lorica (9º14'11.87"N 75º48'54.47"W) and Sahagún (8º56'5.33"N 75º20'99"W) ( Figure). These locations were selected because antibodies against SNV were found in humans and rodents in previous studies (Mattar & Parra 2004, Alemán et al 2006). The general topography is characterised by the outlying spurs of the Caribbean savannahs.…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

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Prevalence of antibody to hantaviruses in humans and rodents in the Caribbean region of Colombia determined using Araraquara and Maciel virus antigens

Guzmán

Máttar

Levis

et al. 2013

Mem. Inst. Oswaldo Cruz

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“…So far in South America, hantavirus pulmonary syndromes have been diagnosed in Argentina, Brazil, Paraguay, Bolivia, Chile, Uruguay, Panama, and recently in Peru, with the identification of numerous viral genotypes in humans and rodents. In Colombia, the first serological studies carried out in the Colombian Caribbean coast were published between 2004 and 2006, reporting the circulation of hantavirus in humans (2) and rodents (3) respectively, using antigens of the Sin Nombre virus (SNV). Later, in 2011, a new hantavirus was genetically identified in rodents of the Colombian Urabá antioqueño region (4).…”

Section: Introductionmentioning

confidence: 99%

Infecciones por hantavirus

Tous

et al. 2017

Rev MVZ Córdoba

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Hantaviruses are the causative agents of hantavirus pulmonary syndrome in humans in the Americas; The primary reservoirs are in the rodents of the subfamily Sigmodontinae. In South America, cases of hantavirus pulmonary syndrome caused by numerous viral genotypes have been diagnosed. In Colombia, different serological studies have reported the circulation of hantavirus in humans and rodents. These viruses act in an intimate association with a rodent species that serves as a reservoir and have a distribution around the wild rodent, being limited to a specific geographic region. In South America, the first HPS-associated hantavirus was described in 1993 in Brazil and was called Juquitiva and from 1993 to 2012, more than 1400 cases had been identified in Brazil. This syndrome should be suspected in all patients with respiratory distress syndrome of unclear etiology, in areas endemic for the disease, especially if accompanied by fever, marked leukocytosis and thrombocytopenia and bilateral interstitial infiltrates. Hemorrhagic febrile syndrome has not yet been described in the Americas. There are no clinical or laboratory signs that are pathognomonic of hantavirus infection. The treatment is based on adequate hydration, use of antipyretics and anti-inflammatories and patients with signs of severity should establish a more aggressive management. Triage is indispensable, patients with co-morbidities have a higher mortality risk and therefore should be hospitalized. Future research in Colombia should be directed to multidisciplinary studies that include viral isolation, different clinical forms of case presentation, epidemiological differences, risk factors, and taxonomy of viruses and rodents.Keyswords: Arenavirus, bunyaviridae, reservoirs, rodentia, public health (Source: DeCS). RESUMENLos hantavirus, virus que son los agentes causantes de síndrome pulmonar por hantavirus en humanos en America; los reservorios primarios están en los roedores de la sub-familia Sigmodontinae. En Suramérica, se han diagnosticado casos del síndrome pulmonar por hantavirus y se han identifico numerosos genotipos virales. En Colombia, se han publicado diferentes estudios serológicos que reportaron la circulación de hantavirus en humanos y roedores. Estos virus actúan en una íntima asociación con una especie de roedor que le sirve de reservorio y presentan una distribución alrededor del roedor silvestre, limitándose a una región geográfica especifica. En Suramérica, el primer hantavirus asociado a SPH fue descrito en 1993 en Brasil y se denominó Juquitiva y desde 1993 hasta el 2012, se habían identificado más de 1400 casos en Brasil. Se debe sospechar de este síndrome en todo paciente con síndrome de distrés respiratorio de etiología no clara, en las zonas endémicas para la enfermedad sobre todo si se acompaña de fiebre, leucocitosis marcada y trombocitopenia e infiltrados intersticiales bilaterales. El síndrome febril hemorrágico aún no se han descrito casos en las Américas. No existen signos clínicos o de laboratorio que sean pato...

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Serologic Evidence of Hantavirus Infection in Humans, Colombia

Cited by 36 publications

References 7 publications

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Prevalence of antibody to hantaviruses in humans and rodents in the Caribbean region of Colombia determined using Araraquara and Maciel virus antigens

Infecciones por hantavirus

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