Serologic Evidence of Lyssavirus Infection in Bats, Cambodia

Reynes, Jean-Marc; Molia, Sophie; Audry, Laurent; Hout, Sotheara; Ngin, Sopheak; Walston, Joe; Bourhy, Hervé

doi:10.3201/eid1012.040459

Cited by 51 publications

(39 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is noteworthy that half of these cases involved included people with regular close contact with bats including bat handlers. Interestingly, several studies involving bats from different Asian countries have shown evidence of virus neutralizing antibodies against rabiesrelated viruses (most commonly ABLV) in up to 19 % of the samples tested (Arguin et al, 2002;Reynes et al, 2004;Lumlertdacha et al, 2005). Although the majority of human rabies cases in the world are reported from Asian countries no evidence has been reported for infection with rabies related viruses in these cases.…”

Section: Discussionmentioning

confidence: 99%

“…Improved surveillance across the continent is required to fully appreciate the epidemiology of these viruses. In addition, serological evidence of predominantly ABLV infection in bats from several Asian countries and WCBV in bats collected in Kenya (with only known isolate from Asia) predicts a more widespread distribution of these viruses than may have been anticipated (Arguin et al, 2002;Reynes et al, 2004;Lumlerthdacha et al, 2005;Kuzmin et al,2008c).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of human rabies in South Africa, 1983–2007

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of human rabies in South Africa, 1983–2007

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Furthermore, it is possible that bats develop persistent EBLV infection, manifested as the long-term carriage of viral RNA without overt disease. In particular, some wild-caught bats have antibody to EBLV for up to 3 years, and viral RNA has been detected in the tissues of apparently healthy bats (14,31,36,40), although it is also possible that bats experience an unapparent acute infection and are subject to continual reinfection.…”

mentioning

confidence: 99%

Phylogeography, Population Dynamics, and Molecular Evolution of European Bat Lyssaviruses

Davis

Holmes

Larrous

et al. 2005

J Virol

110

100

View full text Add to dashboard Cite

European bat lyssaviruses types 1 and 2 (EBLV-1 and EBLV-2) are widespread in Europe, although little is known of their evolutionary history. We undertook a comprehensive sequence analysis to infer the selection pressures, rates of nucleotide substitution, age of genetic diversity, geographical origin, and population growth rates of EBLV-1. Our study encompassed data from 12 countries collected over a time span of 35 years and focused on the glycoprotein (G) and nucleoprotein (N) genes. We show that although the two subtypes of EBLV-1-EBLV-1a and EBLV-1b-have both grown at a low exponential rate since their introduction into Europe, they have differing population structures and dispersal patterns. Furthermore, there were strong constraints against amino acid change in both EBLV-1 and EBLV-2, as reflected in a low ratio of nonsynonymous to synonymous substitutions per site, particularly in EBLV-1b. Our inferred rate of nucleotide substitution in EBLV-1, approximately 5 ؋ 10 ؊5 substitutions per site per year, was also one of the lowest recorded for RNA viruses and implied that the current genetic diversity in the virus arose 500 to 750 years ago. We propose that the slow evolution of EBLVs reflects their distinctive epidemiology in bats, where they occupy a relatively stable fitness peak.

show abstract

“…Bats have been known as reservoir for rabies virus for a long time [1]. Recently, Research in several countries around of Indonesia such as Vietnam, Cambodia, Thailand and Philippines reported that high level of rabies virus exposure in bats population in its region happened [2,3,4,5]. Bats have also been considered as natural hosts of many common human and animal viruses, such as measles, mumps, parainfluenza, canine distemper and hepatitis C viruses [6,7].…”

Section: Introductionmentioning

confidence: 99%

One Health Approach in the Understanding of Possible Diseases Transmission by Fruits Bats

Pramono¹,

Supratikno²,

Artika³

et al. 2018

Proceedings of the 1st International Conference in One Health (ICOH 2017)

View full text Add to dashboard Cite

About 75% of contagious diseases in the world are classified as zoonosis. One among wild animals suspected to spread the disease is bat. Bats have an important role in the spreading of viral diseases. Fruit bat is among bat species that may potentially transmit diseases to human. The transmission of diseases to human population should be associated with the ecology, behavior of bats and bat-human interaction. We observed the fruit bats ecology and behavior in their roosting sites during daytime (from sunrise to sunset) and in human villages area during night. The observation was conducted in Leuweung Sancang National Park, Garut, West Java. Bats often moved around to find a roost that meets their needs. In daytime bats hanged on cave near of beach for taking a rest and in night bats came to plantation in human villages for food. The plantation were cottonwood tree, guava tree, sapodilla tree, mango tree and rubber tree. The dominant behavior activity of bats in groups during daytime was sleeping. Other activities of bats in its group were aggression, self-grooming, wings flapping, biting, playing, fighting and maternal care. The solitary behavior of bats including sleeping and hang-relax or relaxing. The existence of bats interactions (direct contact and body fluid exchange) between individuals in the social behavior and in solitary behavior suggested a possibility of transmission of the agents among the bats such as parasite, bacteria and virus. Based on the observation, human ever had direct contact with bats such as catching and eating the bats or indirectly through contact with the bat feces and or eating the fruit eaten partly by the bats. These direct and indirect contact between human and bat may suggest a possibility of disease transmission to human.

show abstract

Serologic Evidence of Lyssavirus Infection in Bats, Cambodia

Cited by 51 publications

References 10 publications

Epidemiology of human rabies in South Africa, 1983–2007

Epidemiology of human rabies in South Africa, 1983–2007

Phylogeography, Population Dynamics, and Molecular Evolution of European Bat Lyssaviruses

One Health Approach in the Understanding of Possible Diseases Transmission by Fruits Bats

Contact Info

Product

Resources

About