Serologic Evidence of Yersinia Infection in Patients With Anterior Uveitis

Wakefield, Denis; Ståhlberg, T H; Toivanen, Auli; Granfors, Kaisa; Tennant, Carolyn

doi:10.1001/archopht.1990.01070040071033

Cited by 37 publications

(8 citation statements)

References 20 publications

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“…Early studies of Yersinia and AAU [9] were related to post- Yersinia ReA and later to post- Yersinia uveitis [10,11,12,13,14]. Significant titres of serum anti- Yersinia antibodies detected by agglutination test [10] or ELISA, mostly IgA isotype [11], pointed to recent yersinial infection in examined AAU patients.…”

Section: Discussionsupporting

confidence: 41%

“…Serum IgG or IgA immune response to Yersinia was detected by agglutination test in 23% of AAU patients during their first AAU attack [12]. IgM response was detected by ELISA in 43% of AAU patients [13], and IgG rather than IgA by Western blot in AAU patients compared to the controls [14]. In our study anti- Yersinia antibodies were serologically detected in 20% (3/15) of the patients in both the AAU and AAU+SpA groups, whereas 26.7% of the controls were positive.…”

Section: Discussionsupporting

confidence: 38%

“…The sero-prevalence of antibodies to Yersinia enterocolitica [9,10,11,12,13,14], Klebsiella pneumoniae [15,16,17,18,19,20,21], Salmonella enteritidis [22,23,24] and Chlamydia trachomatis [11, 25] in numerous AAU patients indicates that these bacteria might influence the AAU pathophysiology. Helicobacter pylori is a Gram-negative bacterium that has not been considered as a possible aetiological factor in the development of AAU.…”

Section: Introductionmentioning

confidence: 43%

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<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

et al. 2006

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Acute anterior uveitis (AAU) is the most common form of intraocular inflammation, but its aetiology is still unclear. Fifty percent of AAU patients are HLA-B27-positive, and half of these also have spondyloarthropathies (SpA). Numerous serological studies have shown elevated levels of serum antibodies to various Gram-negative bacteria in HLA-B27-positive AAU and SpA patients. Antigenic similarities between these bacteria and host components (HLA-B27) have already been shown. Still, the mechanism underlying these diseases has not been clarified. Among the Gram-negative bacteria, Helicobacter pylori has not been screened in AAU patients. The purpose of our study was to see if this common human pathogen somehow interferes with AAU. In addition Chlamydia trachomatis, Yersinia enterocolitica 03 and 09, Salmonella sp. and Proteus OX19 were also examined. A total of 60 patients consisting of 4 groups (15 patients with AAU, 15 with SpA, 15 with AAU+SpA and 15 healthy control persons) were examined. A high percentage of the serological results of all investigated bacteria was positive: 80% in the AAU, 93.3% in the SpA and 100% in the AAU+SpA group, while it amounted to 66.7% in the control group (p < 0.05). H. pylori showed the highest percentage of positivity in all 3 patient groups (66.7% in the AAU, 73.3% in the SpA and 80% in the AAU+SpA group). In contrast, 26.7% of the controls were anti-H.-pylori-positive, thus showing a statistically significant difference between the patients and the control group (p < 0.05). HLA-B27/B7-CREG positivity was detected in 53.3% of the AAU, 66.7% of the SpA and 93.3% of the AAU+SpA patients and in none of the controls. Our results suggest that H. pylori might be a candidate participating in the development of AAU and SpA. They also support the theory of genetic (HLA-B27) and exogenous factors (Gram-negative bacteria) as probable background of these diseases.

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Section: Discussionsupporting

confidence: 41%

Section: Discussionsupporting

confidence: 38%

Section: Introductionmentioning

confidence: 43%

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<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

et al. 2006

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“…18 In addition, gramnegative bacteria, such as Klebsiella, Salmonella, Shigella, Yersinia, and Chlamydia have been suggested to be involved in the pathophysiology of AAU. [19][20][21][22] In general, during uveitis, the blood-ocular barrier is broken down following the influx of immunocompetent cells, inflammatory materials, and proteins. These mediators, including cytokines and chemokines, are thought to have a major impact on secondarily elevating IOP.…”

Section: Resultsmentioning

confidence: 48%

The effects of Helicobacter pylori infection on intraocular pressure in anterior uveitis

Kim

Park

Choi

et al. 2012

Eye

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“…Inflammation usually occurs 24h following LPS injection, with the posterior compartment also being susceptible (Koizumi et al 2003). The relevance of experimental endotoxin induced uveitis to human uveitis is debated, although evidence is emerging that systemic diseases associated with uveitis, including IBD and ankylosing spondylitis, might be due to shifts in bowel flora (Friswell et al 2010, Strober 2010), and that infections by microbes such as Salmonella , Yersinia and Chlamydia (Huhtinen et al 2001, Wakefield et al 1990) are associated with reactive arthritis in HLA-B27-positive patients. It is clear that even the most basic components of bacterial cells contribute to ocular inflammation in bacterial endophthalmitis as well as other inflammatory conditions.…”

Section: Host Factorsmentioning

confidence: 99%

Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection

Sadaka

Durand

Gilmore

2012

Progress in Retinal and Eye Research

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Serologic Evidence of Yersinia Infection in Patients With Anterior Uveitis

Cited by 37 publications

References 20 publications

<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

The effects of Helicobacter pylori infection on intraocular pressure in anterior uveitis

Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection

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