Serologic markers of viral hepatitis A, B, C, and D in patients with hemophilia

Abstract

Forty-one patients with hemophilia A were studied for the prevalence of serological markers for hepatitis A, hepatitis B, hepatitis C (non-A and non-B hepatitis), and delta hepatitis (hepatitis D). Ten of 41 (24.4%) patients demonstrated hepatitis A antibody and 31 of 41 (75.6%) patients had a serologic marker for previous hepatitis B infection; four of these 31 patients (13%) also demonstrated antibody to delta agent (hepatitis D). Thirty-seven of 41 (90.2%) patients demonstrated antibody for hepatitis C. Nine of 31 (29%) patients with a hepatitis B marker (no hepatitis B vaccinees) were negative for anti-HBc but positive for anti-HBs; all of these nine patients were HIV antibody positive, although they had no overt immunodeficiency. Twenty-six of 41 (63.5%) patients were HIV antibody positive. Of HIV antibody positive patients, 27%, 88%, and 100% demonstrated evidence of a previous hepatitis A, hepatitis B, or hepatitis C, respectively. Of HIV antibody negative patients; 20%, 53%, and 73% of the patients demonstrated evidence of a previous hepatitis A, hepatitis B, or hepatitis C infections, respectively. The difference between HIV antibody positive and HIV antibody negative groups was not significant for hepatitis A but was significant for hepatitis B (P < 0.001) and hepatitis C (P < .001). Of the 31 patients with a hepatitis B serologic marker, all had antibody to hepatitis C. Of 10 patients, without a hepatitis B serologic marker, only 6 (60%) had antibody to hepatitis C.(ABSTRACT TRUNCATED AT 250 WORDS)

Prevalence and clinical implications of occult hepatitis B viral infection in hemophilia patients in Japan

“…The high prevalence of infection with HIV [Tsuchie et al, 1985;Kroner et al, 1994], HCV [ Makris et al, 1990;Troisi et al, 1993], and GBV-C [Hanley et al, 1998;Toyoda et al, 1998] has been reported in many studies. The status of serological markers on HBV infection has also been reported [Kumar et al, 1993;Goedert et al, 2002]. However, occult HBV infection in this population has not been examined.…”

“…High prevalence of infection with hepatitis C virus (HCV) [Makris et al, 1990;Troisi et al, 1993], human immunodeficiency virus (HIV) [Tsuchie et al, 1985;Kroner et al, 1994], and GB virus C (GBV-C) [Hanley et al, 1998;Toyoda et al, 1998] has been reported. A few studies have also been carried out on hepatitis B virus (HBV) infection in this population by serological evaluation [Kumar et al, 1993;Goedert et al, 2002].…”

Hepatitis B Virus Vaccine for Patients with Hepatitis C Virus Infection

“…HCV, like HBV, is transmitted by the parenteral route, and the sources of infection include administration of blood or blood products [13][14][15][16], intravenous drug use [17][18][19][20][21] and needle-stick accidents [22,23]. Nosocomial transmission is not a significant cause of infection in developed countries with the exception of hemodialysis patients, 10-60% of whom are infected [24,25].…”

Hepatitis C - Epidemiologie und Prävention

“…1985 zu einer beträchtlichen Zahl von HCV-Infektionen [57,58,59]. über viele Jahre Blutprodukte erhielten.…”