Serological and genetic evidence for the presence of Seoul hantavirus in Rattus norvegicus in Flanders, Belgium

Heyman, Paul; Baert, Kristof; Plyusnina, Angelina; Cochez, Christel; Lundkvist, Åke; Esbroeck, Marjan Van; Goossens, Els; Vandenvelde, C.; Plyusnin, Alexander; Stuyck, Jan

doi:10.1080/00365540802459994

Cited by 38 publications

(33 citation statements)

References 27 publications

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“…Hantaviruses show high genetic diversity as well as geographical clustering pattern of genetic variants within individual hantavirus type, such as HTNV [Zou et al, 2008a] and PUUV [Sironen et al, 2001]. In contrast, SEOV has been identified worldwide [McCaughey et al, 1996;Weissenbacher et al, 1996;Wang et al, 2000;Heyman et al, 2004Heyman et al, , 2009Plyusnina et al, 2004;Easterbrook et al, 2007;Cueto et al, 2008]. Notably, most of known SEOV variants including the majority of Chinese strains and also those from Brazil, Cambodia Egypt, France, Indonesia, Japan, North America, South Korea, and United Kingdom are genetically homogeneous [Wang et al, 2000;Reynes et al, 2003;Shi et al, 2003;Plyusnina et al, 2004].…”

Section: Introductionmentioning

confidence: 87%

Hantaviruses in small mammals and humans in the coastal region of Zhejiang Province, China

Zhāng

Lin

Shi³

et al. 2010

Journal of Medical Virology

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To gain more insights into the epidemiology of hantaviruses in the coastal region of Zhejiang Province, China, the morbidity and mortality of hemorrhagic fever with renal syndrome (HFRS) were analyzed in two coastal areas: Cixi (hilly terrain) and Wenzhou (mountainous terrain). More HFRS cases have been reported in Cixi than in Wenzhou. Annual incidence rate of HFRS in Cixi had been on the level of approximately 1.5/100,000 from 1968 (when the first HFRS case was reported) to 2007, with the highest incidence rate of 8.54/100,000 in 1999. The annual incidence rate in Wenzhou has been relatively low, less than 0.5/100,000 since the first HFRS case was reported in 1981. A total of 461 rodents and 199 shrews were captured in these two areas. Hantavirus antibodies were detected in 16 of 241 (6.64%) Rattus norvegicus and 13 of 122 (10.66%) R. flavipectus. Interestingly, hantavirus antigens were identified in 6 of 196 (3.06%) Suncus murinus. Genetic analysis showed that partial M and S segment sequences recovered from rats in the two regions belong to Seoul virus (SEOV) and can be assigned into two genetic lineages. SEOV variants that belong to these two lineages of viruses are distributed widely in China and have been found outside China. As most trapped rodents were rats and SEOV was the only hantavirus detected, these results suggested that SEOV plays an important role in human hantavirus infections. They also reinforce the need for vigilance in preventing HFRS caused by hantaviruses in the coastal region.

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Section: Introductionmentioning

confidence: 87%

Hantaviruses in small mammals and humans in the coastal region of Zhejiang Province, China

Zhāng

Lin

Shi³

et al. 2010

Journal of Medical Virology

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“…SEOV hantaviral RNA was also detected in two of 20 pet rats imported into Sweden from the UK in 2011 [14]. SEOV-specific antibodies or viral RNA have been detected in wild rats in the UK [4,15,16], Belgium [17][18][19], France [20,21], Portugal [22] and The Netherlands [23]. Antibodies to Hantaan virus (HTNV) were reported in the UK in healthy (9·6%) and chronically ill (23%) cats [24], but due to cross-reactivity amongst Murinae-associated hantaviruses, this may have indicated exposure to SEOV or other hantaviruses rather than HTNV.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of Seoul hantavirus in a breeding colony of pet rats

et al. 2017

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SUMMARYAs part of further investigations into three linked haemorrhagic fever with renal syndrome (HFRS) cases in Wales and England, 21 rats from a breeding colony in Cherwell, and three rats from a household in Cheltenham were screened for hantavirus. Hantavirus RNA was detected in either the lungs and/or kidney of 17/21 (81%) of the Cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three Cheltenham rats. The partial L gene sequences obtained from 10 of the Cherwell rats and the three Cheltenham rats were identical to each other and the previously reported UK Cherwell strain. Seoul hantavirus (SEOV) RNA was detected in the heart, kidney, lung, salivary gland and spleen (but not in the liver) of an individual rat from the Cherwell colony suspected of being the source of SEOV. Serum from 20/20 of the Cherwell rats and two associated HFRS cases had high levels of SEOV-specific antibodies (by virus neutralisation). The high prevalence of SEOV in both sites and the moderately severe disease in the pet rat owners suggest that SEOV in pet rats poses a greater public health risk than previously considered.

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“…It is suspected to be found almost worldwide. There exist some reports of SEOV detected in brown rats from Belgium (Heyman et al 2009a; and in the Lyon region of France (Heyman et al 2004). SEOV sequences could be generated from two French rural R. norvegicus and these clustered with Indonesian/Cambodian strains.…”

Section: Rodent-associated Hantaviruses Causing Disease In Europe Andmentioning

confidence: 98%

“…A comparison of data from different countries is somewhat difficult, since the temporal onset of official reporting, the quality of official registration systems, case definitions or used assays for hantavirus detection widely differ. Since 2005 data on hantaviruses are available for 30 European countries (Heyman et al 2008(Heyman et al , 2009aEssbauer et al 2013). Infections in humans are often only diagnosed retrospectively by serological assays.…”

Section: Epidemiological Data On Hantaviruses In Europementioning

confidence: 99%

Hantaviruses—Infections, Epidemiology and Hosts

Eßbauer

Krautkrämer

2014

Zoonoses - Infections Affecting Humans and Animals

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Hantaviruses are pathogens of emerging importance in different areas of the world with local outbreaks as reported in 2012 in the Yosemite national park in the US or in several endemic areas in Germany. Quite recently hantaviruses have also been detected on the African continent. The knowledge on respective small mammal hosts and virus types/subtypes has rapidly increased in the last years now including also insectivores, bats and with these several associated new viruses. Usually animals are asymptomatic reservoir carriers, although a few studies show effects on rodent populations. In humans clinical symptoms of hantavirus infections are depending on the virus type causing syndromes of different severity. However, as infections are often clinically inapparent, recorded case numbers may be underestimated. The epidemiology of hantaviruses is complex as multiple biotic and abiotic factors are involved, e.g. rodent population density, corresponding virus prevalence, mast, habitats, biodiversity, rodent ecology, or climate and local weather parameters.

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Serological and genetic evidence for the presence of Seoul hantavirus in Rattus norvegicus in Flanders, Belgium

Cited by 38 publications

References 27 publications

Hantaviruses in small mammals and humans in the coastal region of Zhejiang Province, China

Hantaviruses in small mammals and humans in the coastal region of Zhejiang Province, China

High prevalence of Seoul hantavirus in a breeding colony of pet rats

Hantaviruses—Infections, Epidemiology and Hosts

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