Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran

Rasti, Sima; Hassanzadeh, Malihe; Soliemani, Alireza; Hooshyar, Hossein; Mousavi, Seyed Gholam Abbas; Nikoueinejad, Hassan; Abdoli, Amir

doi:10.3109/0886022x.2016.1172940

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…This result is consistent with the rate reported by Yazar et al [ 53 ] in Turkey (1.7%), but lower than that reported by Aufy et al [ 54 ] in Egypt (16.7%). Moreover, among the included studies, only 3 [ 42 , 47 , 48 ] applied molecular methods (polymerase chain reaction) to detect T. gondii infection. In all those studies, active infection (circulating DNA) was only observed in hemodialysis patients, whereas no controls showed positive results [ 42 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, among the included studies, only 3 [ 42 , 47 , 48 ] applied molecular methods (polymerase chain reaction) to detect T. gondii infection. In all those studies, active infection (circulating DNA) was only observed in hemodialysis patients, whereas no controls showed positive results [ 42 , 47 , 48 ]. This result indicates that hemodialysis patients were more susceptible to acquire T. gondii infection.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Foroutan

Rostami²,

Majidiani

et al. 2018

Epidemiol Health

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OBJECTIVESToxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.METHODSWe searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.RESULTSA total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals.CONCLUSIONSThe current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Foroutan

Rostami²,

Majidiani

et al. 2018

Epidemiol Health

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“…One case, after duplicate, was removed, and 36 cases were excluded according to exclusion criteria i (out of scope) and iv (insufficient available data). In the present review we only analyzed cases regarding SOT recipients published from 1996 to 2016 and available on the PubMed database with sufficient data for inclusion on synthesis of results (n 907) [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , ...…”

Section: Resultsmentioning

confidence: 99%

“…In published and available reviewed literature, we found 162 case reports of toxoplasmosis occurring after SOT [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Of interest, in SOT recipients, toxoplasmosis results more frequently from transmission of the parasite with the transplanted organ from a Toxoplasma -seropositive donor (D+) to a Toxoplasma -seronegative recipient (R−).…”

Section: Discussionmentioning

confidence: 99%

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

2018

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The aim of this study was to evaluate the occurrence of parasitic infections in solid organ transplant (SOT) recipients. We conducted a systematic review of literature records on post-transplant parasitic infections, published from 1996 to 2016 and available on PubMed database, focusing only on parasitic infections acquired after SOT. The methods and findings of the present review have been presented based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. From data published in the literature, the real burden of parasitic infections among SOT recipients cannot really be estimated. Nevertheless, publications on the matter are on the increase, probably due to more than one reason: (i) the increasing number of patients transplanted and then treated with immunosuppressive agents; (ii) the “population shift” resulting from immigration and travels to endemic areas, and (iii) the increased attention directed to diagnosis/notification/publication of cases. Considering parasitic infections as emerging and potentially serious in their evolution, additional strategies for the prevention, careful screening and follow-up, with a high level of awareness, identification, and pre-emptive therapy are needed in transplant recipients.

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“…Antibody of IgM, in hemodialysis patients showed positive data of 5 (6.3%) by ELISA and 4 (5%) by CLIA and in healthy individuals a positive of 4 (5%) was obtained by showed that the prevalence of T. gondii was significant difference between the two groups of control (n = 120) and hemodialysis (n = 135) and this parasite was greater in hemodialysis patients. So that was a positive for 63% hemodialysis patients and 33.3% of healthy individuals (14). (17).…”

Section: Resultsmentioning

confidence: 99%

Seroepidemiological study of toxoplasmosis in hemodialysis patients of Ahvaz, Southwest of Iran

Kazemi

Fallahizadeh

Feizhadad

2018

IJBMPH

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Introduction: Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan that infects most warm-blooded vertebrates. Because of the immunodeficiency in hemodialysis patients, these individuals are at higher risk for reactivating chronic toxoplasmosis; therefore, a diagnosis of early and definitive in these individuals is highly desirable. Thus, the aim of this study is to investigate seroepidemiology of toxoplasmosis in hemodialysis patients of Ahvaz, southwest of Iran during 2015-2016. Methods: This is a cross-sectional study. A total of 160 participants, 80 hemodialysis patients (test group) and 80 healthy persons (control group) were randomly selected. IgG and IgM against T. gondii was measured by CLIA (Chemiluminescence) and ELISA (Enzyme-linked immunosorbent assay) tests. To analyze the data from Chi-square test, and SPSS statistical software of version 21 was used. Result: In hemodialysis patients, 35 (43.8%) and 25 (31.3%) were positive for the antibody of IgG by ELISA and CLIA, respectively. In healthy individuals, a positive result of 22 (27.5%) and 13 (16.3%) were obtained by ELISA and CLIA, respectively. In hemodialysis patients, 5 (6.3%) and 4 (5%) was positive by ELISA and by CLIA, respectively. In healthy individuals, a positive of 4 (5%) were obtained by ELISA and CLIA. The antibodies of IgG in hemodialysis patients was significantly higher than healthy individuals by ELISA and CLIA (P<.05). Conclusion:The prevalence of Toxoplasma in hemodialysis patients was higher than healthy subjects. Our findings show a relatively high prevalence of the parasite among hemodialysis patients and healthy individuals in Ahvaz. So, the health authorities of Ahvaz city must pay more attention to control of the infection, especially in hemodialysis patients.

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Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran

Cited by 24 publications

References 31 publications

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

Seroepidemiological study of toxoplasmosis in hemodialysis patients of Ahvaz, Southwest of Iran

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