Serological evidence for the presence of influenza D virus in small ruminants

Quast, Megan; Sreenivasan, Chithra; Sexton, Gabriel; Nedland, Hunter; Singrey, Aaron; Fawcett, L.; Miller, Grant; Lauer, Dale; Voss, Shauna; Pollock, Stacy; Cunha, Cristina W.; Christopher‐Hennings, Jane; Nelson, Eric; Li, Feng

doi:10.1016/j.vetmic.2015.09.005

Cited by 104 publications

(140 citation statements)

References 8 publications

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“…Z puli przebadanych próbek jedynie 6 surowic (2,8%) reagowało w teście HI, w niskim mianie (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), ze szczepami ludzkimi ICV.…”

Section: Zakażenia Ludzi Idvunclassified

“…Podobne wyniki uzyskano w odniesieniu do kóz -w 1 spośród 5 badanych stad (20%) stwierdzono kontakt zwierząt z IDV, połowa kóz z tego stada posiadała przeciwciała dla IDV, średnie miano przeciwciał wynosiło 77,1, a odsetek seroreagentów dla IDV w całej stawce badanych zwierząt wynosił 25,9% (17). Porównując wyniki uzyskane przy użyciu testów HI i SN stwierdzono, że generalnie były one zgodne, aczkolwiek kilka surowic ujemnych w teście HI (5 spośród 28 badanych próbek) uzyskało wynik dodatni w teście SN, poza tym miana surowic w teście SN były wyraźnie wyższe, w porównaniu do HI, co wskazuje na większą czułość SN, w porównaniu do HI.…”

Section: Zakażenia Małych Przeżuwaczy Idvunclassified

“…W przypadku badania próbek archiwalnych, zebranych w latach 2001-2007, stwierdzono, że niemal wszystkie badane surowice były ujemne, z wyjątkiem 1 próbki surowicy koziej z fermy z Massachusetts, pobranej w kwietniu 2002 r., w której miano przeciwciał dla IDV wynosiło 80 (17).…”

Section: Zakażenia Małych Przeżuwaczy Idvunclassified

“…Stwierdzono, że 8 spośród 29 próbek surowic owczych, dodatnich w badaniu ze szczepem bydlęcym IDV, posiadało także przeciwciała dla szczepu D/OK wyizolowanego od świń, natomiast żadna próbka seronegatywna wobec D/660 nie wykazywała obecności przeciwciał dla szczepu D/OK (17). Biorąc pod uwagę fakt, że miana przeciwciał w testach HI z obydwoma antygenami były zbliżone, nie można wykluczyć, że badane owce miały wcześniej kontakt ze szczepem IDV, który indukuje przeciwciała reagujące krzyżowo z obydwoma antygenami.…”

Section: Zakażenia Małych Przeżuwaczy Idvunclassified

“…Badanie surowic kozich dało nieco inne wyniki -żadna próbka dodatnia wobec szczepu D/660 nie wykazywała obecności przeciwciał dla szczepu D/OK, podczas gdy dwie próbki ujemne wobec szczepu D/660 były dodatnie w teście HI z antygenem D/OK (17).…”

Section: Zakażenia Małych Przeżuwaczy Idvunclassified

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Prevalence of infections with a new type of influenza virus – influenza D virus in humans and animals

Markowska-Daniel¹,

Mickiewicz²,

Witkowski³

et al. 2016

Medycyna Weterynaryjna

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In April 2011, in the USA, a new influenza virus type D (IDV) was isolated for the first time from pigs and then from cows. In the paper the data about the prevalence of this virus in humans and animals are described. It was evidenced that HE protein of IDV could bind to cellular receptors in the epithelium of the human trachea. Moreover, the new virus was shown to infect and spread in ferrets. These findings make it possible to conclude that IDV seems to be able to infect humans and have zoonotic potential. Up to now the percent of human seroconverted to IDV has been low, about 1.3%. The susceptibility of pigs to IDV has been shown in natural and experimental conditions. Virus specific antibodies were detected in 9.5% of pigs. Additionally the isolates from pigs were obtained in the USA and Italy. This suggests that pigs are not the natural reservoir of this virus and the infections are uncommon in pig populations. Several studies demonstrated that the new virus is widely spread in cattle. It was isolated in the USA, Canada, China, France and Italy, which proved that the intercontinental transmission of IDV had occurred. The highest percentage of infected cows, mainly animals manifesting BRDC symptoms, was found in Minnesota, Oklahoma and Mississippi, and it varied from 4.8 to 29.1%. Additionally the virus was detected in 2.4% of healthy animals. Seroconversion was demonstrated in 32.7 to 87.5% of the bovine herds tested in Mississippi and Minnesota, respectively. Retrospective analysis revealed that antibodies specific to IDV had been detected in bovine samples since 2004. This suggests that the new virus has circulated in cattle at least since 2004. The analysis of the relationship between the seroconversion and the age of animals showed that over 50% of cows aged 1–14 years were seropositive. Also more than 90% of newborn calves had maternal antibodies to IDV. The spread of IDV was also linked to the type of farm, with the lowest percentage of animals seroconverting in closed herds and the highest in order-buying facilities. Therefore cattle seem to be the natural host of IDV. In the USA and Canada the infections caused by IDV were also found in sheep and goats. Herd-level and individual-level seroprevalence in sheep was 15.3 and 6.1%, respectively, and these figures were even higher in goats: 20% and 25.9%, respectively. This shows that small ruminants are susceptible to IDV infection. Moreover, retrospective analysis confirmed that one serum from a goat taken in Massachusetts in 2002 was positive to IDV. This suggests that the new virus may have circulated among goats as early as in 2002. Serological studies of chicken and turkey sera from the herds in Minnesota, located near the positive bovine herds, yielded negative results. This might suggest that birds are resistant to IDV infection; however, the number of birds tested is insufficient to substantiate such a statement. The studies aimed at evaluation of zoonotic potential of the new virus proved that it replicated efficiently in the upper respiratory tract of ferrets. This suggests that the new virus may have an influence on public health. In experimental conditions the susceptibility of guinea pigs to IDV infection was also evidenced. In conclusion, all the studies demonstrated that cattle were the natural reservoir of the new virus, despite the fact that humans as well as various animal species could also be infected. Furthermore, cattle are likely to be a potential source of infection for both animals and humans.

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“…Z puli przebadanych próbek jedynie 6 surowic (2,8%) reagowało w teście HI, w niskim mianie (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), ze szczepami ludzkimi ICV.…”

Section: Zakażenia Ludzi Idvunclassified

Section: Zakażenia Małych Przeżuwaczy Idvunclassified

See 3 more Smart Citations

Prevalence of infections with a new type of influenza virus – influenza D virus in humans and animals

Markowska-Daniel¹,

Mickiewicz²,

Witkowski³

et al. 2016

Medycyna Weterynaryjna

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Detection of antibodies against influenza D virus in swine veterinarians in Italy in 2004

Trombetta

Montomoli

Bartolo

et al. 2021

Journal of Medical Virology

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Influenza D virus (IDV) was first isolated from a swine with respiratory disease symptoms in 2011 in the United States. Epidemiological and serological studies support the hypothesis that cattle represent the natural reservoir of IDV with periodical spillover events to other animal hosts. Little is known about the seroprevalence in humans and in specific target groups such as veterinarians in Italy. This study was designed to assess the prevalence of antibodies against two influenza D lineages (D/660 and D/OK) in Italy in archived serum samples from veterinarians working with swine collected in 2004. Serum samples were tested by haemagglutination inhibition (HI) and virus neutralization (VN) assays. Results showed that 4.88% (4/82) of tested samples were positive for D/660 and 2.44% (2/82) for D/OK by HI assay. Three out of four samples showed positivity when tested by VN

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Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea

Kim

Kim²,

Noh

et al. 2017

Arch Virol

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In Korea, H5-subtype highly pathogenic avian influenza (HPAI) has caused huge economic losses in poultry farms through outbreaks of H5N1 since 2003, H5N8 since 2013 and H5N6 since 2016. Although it was reported that long-distance migratory birds may play a major role in the global spread of avian influenza viruses (AIVs), transmission from such birds to poultry has not been confirmed. Intermediate hosts in the wild also may be a potential factor in viral transmission. Therefore, a total of 367 serum samples from wild animals were collected near major migratory bird habitats from 2011 to 2016 and tested by AIV-specific blocking ELISA and hemagglutination inhibition (HI) test. Two mammalian and eight avian species were seropositive according to the ELISA test. Among these, two mammalian (Hydropotes inermis and Prionailurus bengalensis) and three avian (Aegypius monachus, Cygnus cygnus, and Bubo bubo) species showed high HI titres (> 1,280) against one or two H5-subtype AIVs. As H. inermis (water deer), P. bengalensis (leopard cat), and B. bubo (Eurasian eagle owl) are indigenous animals in Korea, evidence of H5-subtype AIV in these animals implies that continuous monitoring of indigenous animals should be followed to understand interspecies transmission ecology of H5-subtype influenza viruses.

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Serological evidence for the presence of influenza D virus in small ruminants

Cited by 104 publications

References 8 publications

Prevalence of infections with a new type of influenza virus – influenza D virus in humans and animals

Prevalence of infections with a new type of influenza virus – influenza D virus in humans and animals

Detection of antibodies against influenza D virus in swine veterinarians in Italy in 2004

Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea

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