Serological pattern of anti-HBc alone infers occult hepatitis B virus infection in high-risk individuals in Iran

Ramezani, Amitis; Banifazl, Mohammad; Eslamifar, Ali; Aghakhani, Arezoo

doi:10.3855/jidc.728

Cited by 40 publications

(37 citation statements)

References 18 publications

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“…However, as our study showed, "anti-HBc alone" donors cannot be acquitted of potential occult HBV infection demonstrated by HBV DNA positivity with undetectable low-level or mutated HBsAg [5,6].…”

Section: Discussionmentioning

confidence: 65%

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Prevalence of "anti-HBc alone" among Syrian blood donors

Muselmani

Habbal

Monem

2014

J Infect Dev Ctries

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Introduction: We aimed to evaluate the prevalence of "anti-HBc alone" among Syrian blood donors, highlighting the possibility of representing occult HBV infection. Methodology: Sera of 3,896 healthy blood donors were tested for both HBsAg and anti-HBc. HBsAg-negative, anti-HBc-positive samples were further tested for the antibodies to HBsAg (anti-HBs), and "anti-HBc alone" sera were tested for HBV DNA. Results: Of 3,830 HBsAg-negative donors, 63 were "anti-HBc alone" donors, five of whom were HBV DNA positive. Conclusions: Greater consideration should be given to the "anti-HBc alone" serological profile in blood screening, premarital testing, organ transplantation tests, and other HBV transmission-related procedures in Syria.

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Section: Discussionmentioning

confidence: 65%

“…Previous reports have shown, however, that HBsAg might not be detected in the serum of infected patients. This can be attributed to chronicity with HBsAg levels below the detection limits [5], HBsAg synthesis downregulation [6], or S gene mutations leading to detection inefficiency [7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of "anti-HBc alone" among Syrian blood donors

Muselmani

Habbal

Monem

2014

J Infect Dev Ctries

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“…Positive results for HBcAb could be considered as a potential threat for transmission of hepatitis B infection (19, 20). Moreover, a noticeable proportion of population with positive HBcAb has occult HBV infection with undetectable HBV- DNA and negative results for serum HBsAg.…”

Section: Discussionmentioning

confidence: 99%

A Population Based Study on Hepatitis B Virus in Northern Iran, Amol

et al. 2014

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Background:Viral hepatitis is a major health problem worldwide. Change in transmission patterns of hepatitis B makes it necessary to re-evaluate its prevalence and risk factors.Objectives:We aimed to determine the prevalence of HBV infection and its related risk factors in Amol city, Northern Iran.Patients and Methods:As a population based study, a cluster sampling approach was used and 6146 individuals from the general population of urban and rural areas of Amol, Iran, from both genders and different ages were enrolled. Inclusion criteria were willingness to participate in the study, being a lifelong resident in Amol city or its surrounding areas with Iranian nationality. Ten milliliters (10 mL) of blood was taken from each study subject and checked regarding hepatitis B markers including HbsAg, HBsAb and HBcAb using a third generation ELISA. The prevalence of HBV infections and its potential risk factors were recorded.Results:The prevalence of HBsAg, HBsAb and HBcAb were estimated as 0.9%, 30.7% and 10.5%, respectively. The mean age of all participants was 43.9 (95% CI: 43.4, 44.3) in females and 55.6 in (n = 3472) males. In our study, there was a significant association between family history of hepatitis, rural residency and presence of HBsAg. There was also a positive correlation between HBcAb and family history of hepatitis, history of other types of hepatic diseases, history of tattooing, traditional phlebotomy, male gender and age. In backward logistic regression, a significant association was found between history of hepatitis in first-degree family members (OR = 13.35; 95% CI: 6.26, 28.47) and place of residence (OR = 2.32; 95% CI: 1.27, 4.22) with presence of HBsAg. There was also a positive correlation between history of hepatitis among first-degree family members (OR = 2.49; 95% CI: 1.52, 4.08), history of tattooing (OR = 2.13; 95% CI: 1.33, 3.42), history of previous hepatitis (OR = 1.87; 95% CI: 1.06, 3.28), male sex (OR = 1.36; 95% CI: 1.12, 1.66) and age (OR = 1.03; 95% CI: 1.03, 1.04) with presence of HBcAb.Conclusions:The prevalence of hepatitis B in Amol City and its surrounding areas was about one percent, a lower rate than other reports from Iran.

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“…OBI is also highly prevalent among hemodialysis patients, those undergoing frequent blood transfusions (as treatment for hemophilia disease, etc. ), blood donors, and intravenous drug users [7][8][9][10][11][12][13]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

Makarem¹,

Hamid

Aleem

et al. 2012

Hepat Mon

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BackgroundWhile prevalence of Hepatitis B virus (HBV) in patients with end-stage renal failure (ESRF) who are undergoing dialysis has decreased significantly during the past few decades, it still remains a distinct clinical problem. The immunosuppressive nature of renal disease often leads to chronicity of the HBV infection and an opportunity for nosocomial spread of the infection among dialysis patients. Egypt is among the countries with intermediate endemicity of HBsAg (range, 2%–7%). Large-scale geographic heterogeneity in HBV prevalence has been reported worldwide and HBV prevalence is especially heterogeneous in Egypt.ObjectivesTo assess the prevalence of occult HBV infection (OBI) in hemodialysis patients with or without chronic hepatitis C (HCV) from Minia and Assuit, Upper Egypt, using HBV DNA assays.Patient and MethodsSera from 145 hemodialysis patients with negative HbsAg were investigated for HBV DNA using real-time polymerase chain reaction (RT-PCR). Only serum samples with repeatedly detectable HBV DNA were considered positive. Patients were divided into 2 groups: HCV RNA positive and HCV RNA negative, based on the results of a third generation enzyme linked immunosorbent assay (ELISA) anti-HCV test and HCV RNA PCR.ResultsHBV DNA was detected in 6 of the 145 patients (4.1%) and HBcAb was detected in 29/145 patients (20%). There were no statistically significant differences in the age, duration of hemodialysis, biochemical parameters, serological markers of HBV, or HBV DNA between patients with and without HCV infection.ConclusionsFour percent of the hemodialysis patients had OBI. There was no significant difference in the prevalence of OBI between hemodialysis patients with or without HCV co-infection.

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Serological pattern of anti-HBc alone infers occult hepatitis B virus infection in high-risk individuals in Iran

Cited by 40 publications

References 18 publications

Prevalence of "anti-HBc alone" among Syrian blood donors

Prevalence of "anti-HBc alone" among Syrian blood donors

A Population Based Study on Hepatitis B Virus in Northern Iran, Amol

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients From Egypt With or Without Hepatitis C Virus Infection

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