Serological profile of TORCH Infection Among Antenatal Women at a Tertiary Care Center in North India

Rajani, Monika

doi:10.22207/jpam.12.4.72

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Toxoplasma, rubella, cytomegalovirus (CMV), herpes simplex virus (ToRCH) co-infection has been reported in six pregnant women in India, with one being seropositive for CMV and rubella. 1 Maternal ToRCH co-infection has been associated with increased risk of abortion. 2,3 However, IgG antibodies against more than one of the ToRCH diseases were found among 0-to 6-month-old infants in Qatar.…”

Section: Introductionmentioning

confidence: 99%

A Clinically Diagnosed Congenital Rubella Syndrome and Congenital Cytomegalovirus Co-infection

Tan¹,

Santiago

Alhasan

2021

Acta Med Philipp

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This is a case of a four-month-old female infant who presented with clinical manifestations of congenital rubella syndrome (CRS) -bilateral cataracts, poorly-dilating pupils, microcorneas, salt and pepper retinopathies seen after cataract extractions, bilateral sensorineural hearing loss, patent ductus arteriosus, microcephaly, history of blueberry spots and low birth weight, and positive serum IgM and IgG tests for rubella. The patient's mother also had prenatal rubella infection. However, the patient also presented with additional set of clinical findings not seen in recent patients with CRS and not commonly reported in literature: visual acuities of poor to no dazzle, bilateral choroidal thickening on ocular ultrasound that spontaneously resolved, optic nerve inflammation that became atrophic, vessel tortuosities seen after cataract extractions, bilateral subependymal cysts with lenticulostriate vasculopathy in basal ganglia, basal ganglia hyperintensity suggestive of calcification, and jaundice. These findings plus the overlapping clinical manifestations with CRS and the positive IgM and IgG for cytomegalovirus (CMV) made us consider a congenital CMV co-infection.CRS already causes significant childhood morbidity. Getting co-infected with CMV in utero worsens morbidity and makes management more difficult. This case presented a congenital co-infection of rubella and CMV and discussed the added challenges in their diagnosis and management.

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Section: Introductionmentioning

confidence: 99%

A Clinically Diagnosed Congenital Rubella Syndrome and Congenital Cytomegalovirus Co-infection

Tan¹,

Santiago

Alhasan

2021

Acta Med Philipp

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“…Bad obstetric history (BOH) can be caused due to genetic, hormonal, abnormal maternal immune response and maternal infections [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Panwar

Bithu

Yadav

et al. 2021

AJMAH

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Background: Congenital infections are transmissible in utero and it can lead to serious foetal outcomes. These infections can be early detected in pregnant women with bad obstetric history for better foetal outcomes. Aim of the Study was to evaluate the association of TORCH infection with bad obstetric history among pregnant women. Study Design: Observational and comparative study Place and Duration of Study: Central laboratory, Department of Microbiology, SMS Medical College, Jaipur between April 2020 and September 2021. Methodology: 260 blood samples of pregnant women (130 with bad obstetric history and 130 pregnant women without bad obstetric history) were collected. and tested for the presence of IgM and IgG antibodies against Toxoplasma gondii, Rubella virus, Cytomegalovirus by Chemiluminescence and Herpes simplex virus using ELISA kits. Results: Overall TORCH IgM seropositivity in high-risk pregnant women was 17.19%. In pregnant women with bad obstetric history, IgM Seropositivity for Toxoplasma gondii was 3.84% (P value .02), rubella 2.34% (P value .30), Cytomegalovirus 5.47% (P value .08), and 6.25% (P value .56) for Herpes-1 and 2 infections and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 16.41% (P value .001), 93.75% (P value .11), 98.44% (P value .55), 48.44% (P value .53) respectively. In pregnant women without bad obstetric history, IgM and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 0/0.77%, 0.76/97.69%, 1.53/99.23% and 4.61/44.62% respectively. The average age of the study population was 27.13 years. Conclusion: As TORCH infections are transmissible in-utero in all the stages of pregnancy and contributes in neonatal and infant deaths, so early diagnosis and appropriate interventions necessary which help in proper management of the pregnant women.

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Pregnancy, infection, and epigenetic regulation: A complex scenario

Pradhan

Mallick

Mishra

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Serological profile of TORCH Infection Among Antenatal Women at a Tertiary Care Center in North India

Cited by 6 publications

References 17 publications

A Clinically Diagnosed Congenital Rubella Syndrome and Congenital Cytomegalovirus Co-infection

A Clinically Diagnosed Congenital Rubella Syndrome and Congenital Cytomegalovirus Co-infection

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Pregnancy, infection, and epigenetic regulation: A complex scenario

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