Serological screening of hepatitis B virus and hepatitis C virus among patients attending a tertiary hospital in Jalingo, Taraba state, Nigeria

Omote, Victor; Emmanuel, Kashibu; Ojumah, Isreal; Adda, Danjuma; Etaghene, Johnson; Ukwamedua, Henry

doi:10.4103/sjhs.sjhs_39_18

Cited by 12 publications

(11 citation statements)

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“…To the best of our knowledge this study represents the largest number of children and adults tested for HBsAg and HBeAg from a health facility in Nigeria and the sub region. The prevalence of 19.7% in our study is higher than recent hospital reports of 11.4% from Kano [30] and 14% from Kaduna [11] but comparable to 19.2% from Jalingo [10] however lower than reports of 25% in Kogi [13], 39% in Makurdi [14] and 63% from Sokoto [12]. In all these reports the proportion of children was small and overall sample sizes were also small compared to our study.…”

Section: Discussioncontrasting

confidence: 76%

“…The northern zones have higher prevalence rate of Hepatitis B. [9] Recent Nigeria studies from Jalingo [10], Kaduna [11], Sokoto [12], Kogi [13] and Makurdi [14] showed the prevalence of Hepatitis B Virus of 19.2%, 14%, 63%, 25% and 39% in various adult subpopulations of hospital patients respectively. Hepatitis B testing methods were different.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis B Envelope Antigen in Children and Adults with Hepatitis B Infection in Tertiary Health Facility in North East Nigeria During the Period 2000-2015

We¹,

Jalo²,

Ajani³

et al. 2021

jhepatres

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Introduction: Worldwide, most people living with chronic HBV infection are in in low- and middle-income countries. Most of the burden of disease from HBV infection comes from infections acquired before the age of 5 years. Materials and Methods: Records of Hepatitis B surface and envelope antigen results of children and adults in Federal Teaching Hospital, Gombe between May 2000 and May 2015 were analyzed Results: 22,862 individuals were tested for Hepatitis B surface antigen. 19.5% (4456) tested positive. 24.7 % (3146) and 12.9% (1310) of males and females respectively were HBsAg positive. HBsAg Peak prevalence of 21.8% was in the age group 26-46 (2533) and the lowest prevalence in infancy (3.5%). Amongst males, the 19-25year age group had the peak prevalence of 28.6% and in females the age group 5-9 years constituted the highest (20.3%). 36% (1602/4456) of HBsAg positive children and adults were tested for HBeAg. 26.2% (420/1602) of individuals with HBsAg carriage were HBeAg. More males (307/1105) than females (113/495) were HBeAg positive but not statistically significant. (P=0.034). Prevalence of HBeAg was highest in infants (50%) and children 1-4 years (50%) age group and thereafter declined with increasing age. Females of the younger age group <1year, 1-4 years and 5-9 years and older age group, 56-65 and >65 years, compared to their male carriers of HBsAg had higher prevalence of HBeAg but these were not statistically significant. Conclusion: A fifth of HBsAg carriers were HBeAg positive and HBeAg positivity decreased with increasing age. Hepatitis B vaccination in Nigeria requires urgent strengthening. Keywords: Hepatitis, HBsAg, HBeAg Children, Adults, Nigeria.

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Hepatitis B Envelope Antigen in Children and Adults with Hepatitis B Infection in Tertiary Health Facility in North East Nigeria During the Period 2000-2015

We¹,

Jalo²,

Ajani³

et al. 2021

jhepatres

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“…However, it is lower than the prevalence of HCV reported among SCD patients in different parts of the country. For example, Lesi and Kehinde [47] found a prevalence of 5% among SCD patients in Lagos, Omote et al [48] reported a prevalence of 5% in SCDs in Jalingo, Taraba state, and Ejiofor found a prevalence of 5% among SCD in Benin City [49]. In a previous study among 180 SCD samples collected from patients in 1998 in Ibadan, by Fasola et al [5] reported an HCV prevalence of 7.2%.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of 0.15% and 0.05% obtained respectively for HBV/HCV and HCV/HIV coinfection is low compared to previous reports in the country. Fasola et al [5] reported an HBV/HCV coinfection rate of 7.2% among SCD patients in Ibadan, while Omote et al [48] found an HBV/HCV prevalence of 1% among patients attending a tertiary hospital in Taraba state. However, the results of our study are similar to those of a study on HIV, HBV and HCV among pregnant women in Anyigba, Nigeria, in which an HIV/HCV coinfection rate of 0.5% was found [53].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HIV, HBV and HCV Infections among Sickle Cell Disease Patients in Southwestern Nigeria: A Case-Control Study

Odaibo¹,

Babalola²,

Akpa³

et al. 2021

WJA

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Aim: This study was designed to determine the prevalence of HBV, HCV and HIV infections among individuals with Sickle Cell Disease (SCD) in Ibadan, southwestern Nigeria. Methodology: In this case-control study, 1017 patients with SCD and 1017 age and gender matched controls were enrolled from 6 health facilities and some communities in Ibadan, southwestern Nigeria. Blood samples were tested for the presence of HIV, HBV and HCV infections. Structured questionnaire was used to capture participants' information and data analyzed using descriptive statistics, McNemar Chi-square/Fishers exact test. Results: Blood transfusion was significantly more common among SCD cases [566 (55.7%)] than controls [54 (5.3%)], while history of vaccination was higher in the control group (p = 0.001). The overall prevalence of HIV [2 (0.2%) vs 11 (1.1%)], HBV [58 (5.7) vs 66 (6.5%)] and HCV [10 (1.0) vs 22 (2.2%)] was lower among SCD cases than controls, respectively, although significantly different only in HCV infection (p = 0.048). All three infections were significantly higher in adults than in children. Co-infection was found only in four of the participants, all of whom were SCD patients. Conclusion: The prevalence of HIV, HBV and HCV infection among SCD patients indicates an improvement in the transfusion safety measures in the region. The prevalence of HBV and HCV found in this study is still relatively high when compared with reports from some other regions.

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“…Pennap, et al [23] reported 3.0% seroprevalence of HCV antibodies in a rural clinic in Northern Nigeria. It was 8.0% among students of University of Ilorin [31], 11.5% among students of Federal Polytechnic, Mubi, Adamawa State [32] and 16.6% among patients attending a tertiary hospital in Jalingo [33]. The differences in prevalence observed across the studies may be due to differences in demographics, socio-economic status, risk behavior and methods of testing employed.…”

Section: Limitationsmentioning

confidence: 99%

Epidemiologic Survey of HBV, HCV and HIV Infections in a Pregnant Women Population in Central Nigeria: A Cross-Sectional Study

Oti¹,

H²,

Ibrahim³

et al. 2021

J Infect Dis Epidemiol

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Parallel and overlapping of HBV, HCV and HIV infections in pregnant women is a major public health problem. In this cross-sectional study, we evaluated the parallel and overlapping infections of HBV, HCV and HIV among pregnant women population in Keffi, Central Nigeria between June through August 2019. Four hundred (400) women blood specimens were collected from major Hospitals in Keffi for the study after informed consent and ethical approval were retrieved and a structured questionnaire was administered to each women before sample collection. Specimens were analyzed for HBsAg, anti-HCV and anti-HIV antibodies using rapid test kits according to the manufacturer's instructions. Information obtained were statistically analysed using SSP version 2.80 and any P values less than 0.05 were reflected statistically significant. Out of the 400 women screened, there was overlapping infections of 11 (2.8%), 6 (1.5%) and 3 (0.8%) for HBV/HCV, HBV/HIV and HCV/HIV respectively. Parallel infections were 22 (5.5%), 12 (3.0%) and 14 (3.5%) for HBV, HCV and HIV. Only educational status was statistically related to HCV infection (p < 0.05). Those women that were below 20-years-old had the highest prevalence of HBV and HIV, meanwhile, women aged > 51 years recorded the highest prevalence for infection due to HCV. The parallel and overlapping HBV, HCV and HIV infections reported in this study is a stimulant for more proactive measures towards eliminating these viruses among pregnant women in Nigeria.

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Serological screening of hepatitis B virus and hepatitis C virus among patients attending a tertiary hospital in Jalingo, Taraba state, Nigeria

Cited by 12 publications

References 0 publications

Hepatitis B Envelope Antigen in Children and Adults with Hepatitis B Infection in Tertiary Health Facility in North East Nigeria During the Period 2000-2015

Hepatitis B Envelope Antigen in Children and Adults with Hepatitis B Infection in Tertiary Health Facility in North East Nigeria During the Period 2000-2015

Prevalence of HIV, HBV and HCV Infections among Sickle Cell Disease Patients in Southwestern Nigeria: A Case-Control Study

Epidemiologic Survey of HBV, HCV and HIV Infections in a Pregnant Women Population in Central Nigeria: A Cross-Sectional Study

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