Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis

Gadisa, Endalamaw; Tasew, Geremew; Abera, Adugna; Gelaye, Woyneshet; Chanyalew, Menberework; Abebe, Markos; Laskay, Tamás; Aseffa, Abraham

doi:10.1016/j.cyto.2016.11.016

Cited by 5 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher levels of sCD40L have also been reported in untreated HIV patients than in ART-treated HIV patients (Olmo et al, 2012), but this could not be confirmed in our VL-HIV group (Table 2). Previously published data in VL patients also showed very low sCD40L levels (de Oliveira et al, 2013; Gadisa et al, 2017), supporting the hypothesis of a specific parasite-driven inhibition of the CD40 costimulatory pathway. L. major amastigotes were shown to modulate the CD40-CD40L pathway downstream by inducing ERK1/2 and IL-10 production, which inhibits the p38MAPK/IL12 pathway resulting in persistence of infection (Subauste, 2009; de Oliveira et al, 2015).…”

Section: Discussionsupporting

confidence: 63%

“…Comparable levels of sCD40L were found in the serum of asymptomatic Leishmania antibody positive HIV patients and endemic healthy controls. In the latter, levels were slightly higher compared to previously published endemic healthy controls in Ethiopia (Gadisa et al, 2017). In particular, serum levels of sCD40L were significantly decreased in diseased VL-HIV patients.…”

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients

Adriaensen

Abdellati

Henten

et al. 2018

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Human Immunodeficiency Virus (HIV) co-infection drastically increases the risk of developing overt visceral leishmaniasis (VL). The asymptomatic Leishmania infection window constitutes an opportunity to identify those HIV patients at highest risk by defining early markers associated with disease susceptibility or resistance. As intracellular parasite killing is essential, we investigated whether serum markers of macrophage activation were notably affected in HIV patients with an asymptomatic Leishmania infection or overt visceral leishmaniasis disease. Serum levels of soluble CD40 ligand and neopterin were assessed in 24 active VL-HIV patients, 35 HIV patients with asymptomatic Leishmania infection and 35 HIV endemic controls. All patients were recruited in L. donovani endemic regions of North-West Ethiopia. The serum levels of sCD40L and neopterin significantly decreased and increased in HIV patients with active VL compared to HIV patients with asymptomatic Leishmania infection, respectively. No statistically significant differences could be detected in neopterin and sCD40L levels between Leishmania asymptomatically infected HIV patients and endemic HIV control patients. However, an inverse trend, between Leishmania antibody positivity or VL development and neopterin levels could be seen. The CD4+ T-cell count was inversely correlated with serum neopterin levels, but not with sCD40L levels. Our results in HIV coinfected patients, correspond with the postulated protective role of sCD40L in VL and underline the importance of the CD40-CD40L pathway in resistance against the parasite. Neopterin levels suggest an increased macrophage activation upon infection and could have a value in clinical algorithms to, although non-specifically, improve prediction of VL development in HIV patients with asymptomatic Leishmania infection.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Discussioncontrasting

confidence: 55%

Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients

Adriaensen

Abdellati

Henten

et al. 2018

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Whereas some studies associate MMP-9 as prognostic biomarker for visceral leishmaniasis (de Oliveira et al 2013; Gadisa et al 2017), one study related that MMP-9 may represent a biomarker to prognosticate an increased risk for parasite dissemination and development of mucosal leishmaniasis (Maretti-Mira et al 2011 a ). The high levels of this enzyme indicate an increased risk of parasitic spread and development of the mucosal form of leishmaniasis.…”

Section: Resultsmentioning

confidence: 99%

“…stimulates host MMPs production by infected macrophages, leading to the breakdown of cell matrix, which promotes the dissemination of parasite to another site (Liarte et al 2001; Carvalhal et al 2004). The role of host MMP has been recently studied and it is related to the clinical development of visceral leishmaniasis in humans and dogs (Machado et al 2010; Marangoni et al 2011; Melo et al 2011; de Oliveira et al 2013; Gadisa et al 2017). Host MMPs serological or tissue levels have been considered as new and simple biomarkers for monitoring the success of therapy and predicting favourable clinical outcome of human visceral leishmaniasis (de Oliveira et al 2013; Gadisa et al 2017).…”

Section: Introductionmentioning

confidence: 99%

The role of metalloproteases inLeishmaniaspecies infection in the New World: a systematic review

et al. 2018

View full text Add to dashboard Cite

This is a systematic review on the role of metalloproteases in the pathogenicity of the American tegumentary leishmaniasis (ATL) caused by New World Leishmania species. The review followed the PRISMA method, searching for articles in PubMed, EMBASE, LILACS and ISI Web of Science, by employing the following terms: 'leishmaniasis', 'cutaneous leishmaniasis', 'mucocutaneous leishmaniasis', 'diffuse cutaneous leishmaniasis', 'Leishmania' and 'metalloproteases'. GP63 of New World Leishmania species is a parasite metalloproteases involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the host's immune functions, allowing the survival of the parasite and its dissemination. High serological/tissue levels of host matrix metalloproteases (MMP)-9 have been associated with tissue damage during the infection, while high transcriptional levels of MMP-2 related with a satisfactory response to treatment. Host MMPs serological and tissue levels have been investigated using Western Blot, zymography, and Real Time polymerase chain reaction. GP63 detection characterizes species and virulence in promastigotes isolated from lesions samples using techniques mentioned previously. The monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples could be used on the laboratory routine to predict the prognostic and treatment efficacy of ATL.

show abstract

“…A poor nutritional status is related to a weak sodium gluconate chemotherapy response and decreased serum levels of metal matrix metalloproteinase 9 (MMP9), a cytokine that is negatively correlated with disease progression. 30,31 According to historical reports and recent experimental animal studies, malnutrition is usually considered to be a major cause for the development of active tuberculosis. Tuberculosis is one of the well-documented examples of major global disease burdens in which malnutrition leads to worse disease outcomes.…”

Section: Effects Of Infection On Nutritional Statusmentioning

confidence: 99%

Nutrition Metabolism and Infections

Yang¹,

Yang²,

Zeng

et al. 2021

Infectious Microbes and Diseases

View full text Add to dashboard Cite

Infection and nutrition are intricately interacted and further influence human health. Infections are a worldwide health problem and malnutrition plays a significant role in the emergence of infection. Growing evidence suggests that the optimization of dietary nutrients intake is crucial in maintaining systemic immunity and may help improve resistance to infections. In this review, we explore a wide range of topics including interactions between nutrients and various infectious diseases. We also discuss the role of diet-induced gut microbiota in the infection-nutrition cycle and review how dietary-microbiome crosstalk may affect disease development and progression, which may provide an attractive option to the design of a diet leading to favorable outcomes in the future. We will also present evidence and propose mechanisms of nutrients that may specifically modulate host immunity and metabolism to infectious pathogens and also cover its influence on nutrition, focusing on immuno-nutrients. We provide representative nutrients in the present review based on their intensive studies and wide acceptance of their immuno-modulating properties. Moreover, the efficacy and translational cost of their plausible utility to be anti-infective nutrients are also reviewed. Finally, we highlight the current progress and challenges to gain a better understanding of the research into microbiota, infectious diseases, and nutrition with an emphasis on future research directions.

show abstract

Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis

Cited by 5 publications

References 19 publications

Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients

Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients

The role of metalloproteases inLeishmaniaspecies infection in the New World: a systematic review

Nutrition Metabolism and Infections

Contact Info

Product

Resources

About