Foot and mouth disease (FMD) remains the most important animal disease. The FMD virus is highly contagious and occurs almost exclusively among clovenhoofed animals such as cattle, sheep, goats, Bactrian camels and swine. Old World camels (OWCs) and New World camels (NWCs) inhabit FMD-endemic countries in South America, North and East Africa, and the Middle and Far East. Results of experimental infection of OWCs with the virus, and several clinical observations from the field over a century, confirm that the two closely related camel species of Bactrian and dromedary camels possess noticeably different susceptibilities to FMD. It is now certain that Bactrian camels can contract the disease. In contrast, dromedaries are not susceptible to FMD and do not transmit infection, even when in close contact with susceptible animals. The susceptibility of NWCs to the FMD virus has been demonstrated in the field and in experimental infection trials. However, these animals are not very susceptible and do not represent a serious risk in transmitting FMD to susceptible animal species.