Serological survey to detect subclinicai junían virus infection in laboratory personnel

Abstract

Serological survey for detecting subclinical infections with Junín virus, the etiological agent of Argentine hemorrhage fever, was carried out in a group of 107 individuals working in laboratories where this virus was handled. The group was divided into high risk and low risk personnel according to the degree of exposure to the virus. Neutralizing tests were performed in Vero cell cultures to detect circulating antibodies. Results were evaluated comparatively with those obtained in a previous survey. This study shows that among high risk personnel three out of 52 developed neutralizing antibodies (NA) against Junín virus; one of them had a mild clinical illness, and the other two showed no overt disease during this period. No one among the low risk group developed NA against Junín virus.

Junin virus activity in two rural populations of the Argentine hemorrhagic fever (AHF) endemic area

“…Previous studies had shown that Junin virus produces inapparent infection in human beings, both among rural workers of the endemic area and also among laboratory personnel working with Junin virus [Weissenbacher et al, 1976;Weissenbacher et al, 1978;Weissenbacher et al, 1980;Guerrero et al, 19821. The results of the present study demonstrate that the prevalence of inapparent infection is lower than that of clinical infection, in contrast to many other viral diseases.…”

“…The serum samples were taken during the same time period under comparable conditions. The neutralization test was sensitive enough to determine the antibodies in all individuals who had suffered from the disease between 2 and 14 years previously, confirming the long-term persistence of neutralizing antibodies [Weissenbacher et al, 19761. Previous studies had shown that Junin virus produces inapparent infection in human beings, both among rural workers of the endemic area and also among laboratory personnel working with Junin virus [Weissenbacher et al, 1976;Weissenbacher et al, 1978;Weissenbacher et al, 1980;Guerrero et al, 19821. The results of the present study demonstrate that the prevalence of inapparent infection is lower than that of clinical infection, in contrast to many other viral diseases.…”

Sanitary Protection of the Territory from Importation and Spread of Particularly Dangerous Infections. Communication 6. Argentine and Bolivian Hemorrhagic Fevers

“…Вирусемия чаще регистрировалась в острый период заболевания, а примерно через 20 дней после инфицирования -в единичных случаях [16]. Ненарушенная репродуктивная способность хозяев и эффективность постнатального переноса вируса Хунин указывают на вероятный вклад вертикальной передачи в поддержание вируса во времени [74]. G.Carballal и соавт.…”