Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia

Nascimento-Carvalho, Amanda C; Vilas-Boas, Ana-Luisa; Fontoura, Maria-Socorro H; Xu, Man; Vuorinen, Tytti; Söderlund‐Venermo, Maria; Ruuskanen, Olli; Nascimento‐Carvalho, Cristiana M.

doi:10.1002/ppul.23891

Cited by 16 publications

(22 citation statements)

References 28 publications

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“…Herein, HBoV1 was more frequently found in multiple then in sole virus detection (Table 3). However, we have demonstrated that acute serologically diagnosed HBoV1 infection occurred in 22.5% of cases with multiple virus detection, as well as in 50.0% of cases with sole virus detection [13]. The challenge is to show causativeness.…”

Section: Discussionmentioning

confidence: 91%

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Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study

Nascimento-Carvalho

Vilas-Boas

Fontoura

et al. 2018

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 91%

“…The in-house triplex PCR test and Anyplex II RV16 detected RV, EV, and RSV in 77.6% and 69.9% of the NPA samples, respectively. Data on acute HBoV1 infection diagnosed by serology have been published elsewhere [13].…”

Section: Resultsmentioning

confidence: 99%

Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study

Nascimento-Carvalho

Vilas-Boas

Fontoura

et al. 2018

Journal of Clinical Virology

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“…19 Além disso, a infecção aguda por HBoV foi sorologicamente confirmada em 38 (5,0%) dos 759 casos com amostras de soro pareadas disponíveis. 20 Infecções bacterianas típicas também foram pesquisadas, com a quantificação de títulos específicos de IgG: de 690 pacientes com amostras de soro pareadas disponíveis para esses ensaios, a taxa de respostas de anticorpos foi de 15,4% para pelo menos um antígeno da proteína pneumocócica, 5,8% para H. influenzae e 2,3% para M. catarrhalis, a taxa de detecção de anticorpos foi significativamente aumentada para pelo menos uma dessas três bactérias para 20,4%. 21 Foram também investigadas infecções bacterianas atípicas: a infecção aguda por M. pneumoniae foi diagnosticada pela detecção de anticorpos IgM específicos na amostra de soro convalescente, infecções agudas por Chlamydia pneumoniae e Chlamydia trachomatis foram diagnosticadas pela detecção de anticorpos IgM específicos ou mudanças significativas nos títulos de IgG ou IgA; foram diagnosticadas infecções agudas por M. pneumoniae (86/787; 10,9%), C. pneumoniae (79/733; 10,8%) e C. trachomatis (3/28; 10,7%) e 147 (20,1%), 731 pacientes investigados para essas três bactérias tinham infecção aguda por pelo menos uma dessas três bactérias (18 pacientes tinham testes concomitantemente positivos para infecção aguda por M. pneumoniae e C. pneumoniae).…”

Section: Etiologiaunclassified

Community-acquired pneumonia among children: the latest evidence for an updated management

Nascimento‐Carvalho¹

2020

Jornal de Pediatria

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Objective: To provide cutting-edge information for the management of community-acquired pneumonia in children under 5 years, based on the latest evidence published in the literature. Data source: A comprehensive search was conducted in PubMed, by using the expressionsAll articles retrieved had the title and the abstract read, when the papers reporting the latest evidence on each subject were identified and downloaded for complete reading. Data synthesis: In the era of largely implemented bacterial conjugate vaccines and widespread use of amplification nucleic acid techniques, respiratory viruses have been identified as the most frequent causative agents of community-acquired pneumonia in patients under 5 years. Hypoxemia (oxygen saturation ≤96%) and increased work of breathing are signs most associated with community-acquired pneumonia. Wheezing detected on physical examination independently predicts viral infection and the negative predictive value (95% confidence interval) of normal chest X-ray and serum procalcitonin <0.25 ng/dL was 92% (77---98%) and 93% (90---99%), respectively. Inability to drink/feed, vomiting everything, convulsions, lower chest indrawing, central cyanosis, lethargy, nasal flaring, grunting, head nodding, and oxygen saturation <90% are predictors of death and can be used as indicators for hospitalization. Moderate/large pleural effusions and multilobar infiltrates are predictors of severe disease. Orally administered amoxicillin is the first line outpatient treatment, while ampicillin, aqueous penicillin G, or amoxicillin (initiated initially by intravenous route) are the first line options to treat inpatients. Conclusions: Distinct aspects of childhood community-acquired pneumonia have changed during the last three decades.

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“…Since its discovery in 2005, it has been found globally throughout the year (Allander et al, 2005;Qui et al, 2017). Studies have shown that HBoV1 causes lower respiratory tract infections (LRTIs) like bronchiolitis, acute wheezing and pneumonia, mainly in young children, aged six months to five years (Kesebir et al, 2006;Allander et al, 2007;Fry et al, 2007;Söderlund-Venermo et al, 2009;Christensen et al, 2010;Don et al, 2010;Qui et al, 2017;Nascimento-Carvalho et al, 2018). Although the exact clinical picture of an acute HBoV1 infection remains unclear, the most frequently described clinical symptoms of HBoV1-associated infection include fever, cough, rhinitis and wheezing (Jartti et al, 2012;Qui et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Serodiagnosis of Human Bocavirus 1 Infection among Hospitalised Children with Lower Respiratory Tract Infection in Latvia

Ziemele

Vilmane

et al. 2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Contributed by Modra MurovskaSince its discovery in 2005, human bocavirus 1 (HBoV1) has globally been one of the most common respiratory viruses. It is currently accepted that HBoV1 is a pathogen, causing upper and lower respiratory tract infections (LRTIs) in children. However, due to the prolonged HBoV1 DNA shedding from the upper airways and the subsequent high rate of co-detections with other respiratory viruses, the interpretation of positive polymerase chain reaction results is challenging. The aim of this study was to identify acute HBoV1 infections by the presence of HBoV1-specific IgM and IgG measured by competition enzyme immunoassay, to elucidate the induction of Th1/Th2 cytokines, and to describe the clinical characteristics associated with acute HBoV1 infection in hospitalised children less than five years of age with LRTI. HBoV1 IgM was detected in 19/102 (18.6%) and IgG in 66/102 (64.7%) patients. HBoV1 IgM was most frequently found in patients aged 13 to 24 months. Pneumonia and acute wheezing were the most common clinical diagnoses among HBoV1 IgM positive patients. The seroprevalence of HBoV1-specific IgG increased with age, reaching 85% by the age of five years. were observed to be higher in patients with acute HBoV1 infection.

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Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia

Abstract: Aim: To assess the role of human bocavirus 1 (HBoV1) as a causative agent of nonsevere community-acquired pneumonia (CAP) in children.

Cited by 16 publications

References 28 publications

Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study

Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study

Community-acquired pneumonia among children: the latest evidence for an updated management

Serodiagnosis of Human Bocavirus 1 Infection among Hospitalised Children with Lower Respiratory Tract Infection in Latvia

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