Seromucinous hamartoma of inferior turbinate

Abstract

Rationale:Seromucinous hamartoma is a rare benign glandular proliferation of the sinonasal tract and nasopharynx, and the majority of lesions occur on the posterior nasal septum.Patient concerns:The patient had complaints of rhinorrhea, sneezing, and itching for a number of years, and recurrent right nasal bleeding for which the patient underwent endoscopic removal of a right inferior turbinate tumor. The biopsy result was low-grade, non-intestinal type adenocarcinoma, and the patient was referred to our hospital.Diagnosis and Interventions:An endoscopic medial maxillectomy of the right nasal cavity was performed. The histopathological analysis of the nasal mass revealed a seromucinous (glandular) hamartoma.Outcomes:The postoperative course was unremarkable. The patient has been followed up regularly for 1 year with no additional treatment and no recurrence.Lessons:Seromucinous hamartoma of the nasal cavity is extremely rare, especially in anterior portion of nasal cavity. It is important to distinguish seromucinous hamartoma from adenocarcinoma and to maintain regular long-term follow-up.

Sinonasal cancer: an overview of the emerging subtypes

“…Immunohistochemistry is not helpful in differentiating these two entities, but pathologists can appreciate that low-grade adenocarcinoma has more complex growth patterns, including micropapillary architecture and crowded glandular proliferation. 25,26…”

Middle Turbinate Seromucinous Hamartoma in a Patient With Primary Atrophic Rhinitis

“…1 This lesion typically arises on the posterior nasal septum and in the nasopharynx, although SH has also been observed on the lateral nasal wall. 1,2 Only 39 cases of SH have been previously described in the literature. [1][2][3][4][5] The male to female ratio is 3:2.…”

“…1,2 Only 39 cases of SH have been previously described in the literature. [1][2][3][4][5] The male to female ratio is 3:2. 1 The most common symptoms are nasal obstruction, mucopurulent secretion, and epistaxis.…”

“…It is unclear whether these lesions are true benign neoplasms or developmental tumor-like lesions. [1][2][3][4][5] According to the 4th edition of the World Health Organization Classification of Head and Neck Tumors, SH and respiratory epithelial adenomatoid hamartoma (REAH) are classified as ''respiratory epithelial lesions.'' 6 The differential diagnosis for SH includes inflammatory nasal polyps, REAH, and low-grade sinonasal adenocarcinoma (LGSNA).…”

“…Seromucinous hamartoma is characterized by numerous seromucinous glands, which are not present in inflammatory polyps. [1][2][3][4][5] The stroma of inflammatory polyps is more edematous and the surface is smooth. 1 REAH is the most common hamartoma in the sinonasal tract, characterized by proliferation of pseudostratified respiratory epithelium-lined pseudoglands.…”