Seropositivity and pattern of viral hepatitis in clinically suspected cases of hepatitis in Dhaka city

Rahman, Md. Tahminur; Sultana, Rosy; Chowdhury, Sohel Reza

doi:10.3329/bmrcb.v33i3.1142

Cited by 5 publications

(8 citation statements)

References 11 publications

(10 reference statements)

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“…Studies from Dhakka, Bengladesh and Pakistan reported higher prevalence rates in males versus females 26,27.…”

Section: Discussionmentioning

confidence: 93%

“…Prevalence of anti-HCV antibody in Uzbekistan was 2.2% in low-risk group 38; whereas, it was found to be 5.4% in 2,995 people from Dhaka, Bengladesh 24,26, and 4.56% in Romaine showing an urban distribution as 3.05% in Bucharest, 3.27% in Craiova and 6.37% in Constanta, and high rate in Constanta has been considered significant 25. Again in the same region in Italy, prevalence of anti-HCV antibody positivity was found 2.6% 32.…”

Section: Discussionmentioning

confidence: 95%

“…In an 11-year surveillance study conducted in Pakistan, prevalence of HBsAg positivity was found to be 2.5% in 47,043 patients, whereas it was found to be 8.1% in 2,995 subjects from Dhaka, Bangladesh 26,27.…”

Section: Discussionmentioning

confidence: 96%

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Eight-Year Seroprevalence of HBV, HCV and HIV in Diyarbakir Training and Research Hospital

Turhanoğlu¹,

Onur²,

Bilman³

et al. 2013

Int. J. Med. Sci.

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Distribution of HBV, HCV and HIV results of the inpatients or outpatients, who had been treated for various diagnoses in Diyarbakır Training and Research Hospital between 2005 and 2012, among years was investigated.Files of the patients, who had been treated as inpatient or outpatient 992. to any diagnosis between 01/01/2005 and 31/12/2012 in the clinics or policlinics of Diyarbakır 581 due Training and Research Hospital, were retrospectively reviewed using patient file database. Serum samples (235.534 for HBsAg, 196.727 for Anti-HBs antibody, 98.497 for HBeAg, 97.417 for Anti-HBe antibody, 225.483 for HCV and 138.923 for HIV) of these patients, which had been processed in microbiology laboratory, were studied by chemiluminescence technique using Roche E-170 (Modular Analytics System) device.Prevalence rates between 2005 and 2012 were as follows: 15.9%-9% for HBsAg, 32.9%-52.3% for Anti-HBs, 2.5%-1.8% for HBeAg, 30.4%-25.2% for Anti-HBe, 1%-0.7% for Anti-HCV, and 0.1%-1% for Anti-HIV. Increase in Anti-HBs prevalence is the successful outcome of routine immunization in population. This suggests that, governmental policies focused on this subject have resulted in successful outcomes and that people also take care about this.A prevalence rate decreasing to 9% from 15.9% for HBsAg and prevalence rate increasing to 52.3% from 32.9% for Anti-HBs antibody positivity in 8-year period in our region is quite meaningful. Such favorable developments in our region are of great valuable in terms of indicating to what extent could struggle against HBV is controlled by education and awareness.

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“…Studies from Dhakka, Bengladesh and Pakistan reported higher prevalence rates in males versus females 26,27.…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

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Eight-Year Seroprevalence of HBV, HCV and HIV in Diyarbakir Training and Research Hospital

Turhanoğlu¹,

Onur²,

Bilman³

et al. 2013

Int. J. Med. Sci.

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“…In recent years viral hepatitis is a major public health problem worldwide. As with other Asian countries, Bangladesh is also hyper-endemic for HBV related liver disease, with seroprevalence of HBsAg is 6–7 % (Rahman et al 2007 ). However, data on genotype or subtype of HBV are not sufficient.…”

Section: Discussionmentioning

confidence: 99%

“…However, data on genotype or subtype of HBV are not sufficient. Some previous studies were conducted based on the serological assay where they have only shown the sero-prevalence HBV in Bangladesh (Rahman et al 2007 ; Zaki et al 2003 ). In this study, we have tried to find out the distribution of genotypes and subtypes in Bangladesh, because, genotyping and subtyping of HBV has its great implementation as HBV have their characteristic geographical distribution.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of genotypes and subtypes of hepatitis B viruses in Bangladeshi population

et al. 2016

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The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Based on sequence divergences in the entire genome of >8 %, HBV genomes have been classified into ten genotypes designated as A to J. The aim of this study was to determine HBV genotypes and subtype in samples of HBV infected patients in Bangladesh. The sera samples were collected from chronically infected HBV patients. At first the DNA positive HBV samples were screened by EIA in our laboratory and the 1063 bp region of surface gene was amplified, sequenced and genotyped by sequence analysis. The same sequences were also used for subtypes and mutational analyses. After that, genotyping was also carried out by nested PCR using genotype specific primers in the same region of HBV surface gene. A total of 39 samples were sequencing to find out the genotypes and subtypes. It was found that the prevalent genotype was genotype C (subgenotype C1) which accounted for 48.7 %. The other genotypes found were genotype A (23.1 %) and genotype D (28.2 %). Predominant subtypes in Bangladesh were adr (41 %) followed by subtype adw2 (28.2 %), ayw3 (25.6 %), and others. Additionally, genotyping was also done by nested PCR using type-specific primers. In this method, out of 17 samples 6 were found to be genotype C, followed by genotype D (4 of 17) and genotype A (3 of 17). In PCR-based genotyping system we also observed the mix genotypes; 3 samples contained both genotype A and D, and 2 samples contained both C and D. The genetic diversity of HBV and distribution of its genotypes and subtypes amongst Bangladeshi population were done in this study, which will help us to provide information regarding circulating genotypes in this region and also help physicians to prescribe proper antiviral/interferon therapy.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-1840-2) contains supplementary material, which is available to authorized users.

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The impact of COVID-19 on hepatitis B and C virus prevention, diagnosis, and treatment in Bangladesh compared with Japan and the global perspective

Hussain,

Ali,

Sugiyama

et al. 2023

BMC Health Serv Res

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Aim This study aimed to assess the effect of COVID-19 on hepatitis-related services in Bangladesh and compared the situation with same study conducted in Japan and globally. Methods We conducted an online cross-sectional questionnaire survey among the clinicians of four societies associated with liver disease in Bangladesh from October to December 2022. The questionnaire included the same questions as a survey conducted in Japan and globally. Results A total of 83 clinicians from 8 divisions in Bangladesh participated; 66.3% were heads of departments/institutions. Except for HCV treatment initiation, more than 30% of clinicians reported a 76–99% decline in all services. Compared to Japan and the global survey, there was a significantly higher decline in all HBV and HCV services in Bangladesh. To resume services back to pre-COVID-19 levels, Patient anxiety and fear (Bangladesh Survey: 80.7% vs Japan Survey: 67.4% vs Global Survey: 37.9%, p < 0.0001), loss of space due to COVID-19 (Bangladesh Survey: 63.9% vs Japan Survey: 34.7% vs Global Survey: 19.4%, p < 0.0001) were the main challenges. As part of the mitigation strategy, usage of telemedicine (Bangladesh Survey: 83.1% vs. Japan Survey: 67.3% vs Global Survey: 78.6% p < 0.0001), COVID-19 benefits, such as increased laboratory testing platforms (Bangladesh Survey: 77.1% vs Japan Survey: 17.9% vs Global Survey: 41.8%, p < 0.0001) was reported significantly higher in Bangladesh than in Japan and global survey. Conclusion All the services-related to HBV and HCV were highly affected during greatest impact month of COVID-19 in Bangladesh and the decline level was higher than Japan and global survey. Repeated countermeasures of COVID-19 and constrained healthcare-system were the probable reasons in Bangladesh. Positive impact resulting from COVID-19 countermeasures should be utilized in the national hepatitis program in Bangladesh.

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Seropositivity and pattern of viral hepatitis in clinically suspected cases of hepatitis in Dhaka city

Cited by 5 publications

References 11 publications

Eight-Year Seroprevalence of HBV, HCV and HIV in Diyarbakir Training and Research Hospital

Eight-Year Seroprevalence of HBV, HCV and HIV in Diyarbakir Training and Research Hospital

Prevalence of genotypes and subtypes of hepatitis B viruses in Bangladeshi population

The impact of COVID-19 on hepatitis B and C virus prevention, diagnosis, and treatment in Bangladesh compared with Japan and the global perspective

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