Seroprevalence and epidemiological characteristics of Mycobacterium avium subsp. paratuberculosis on 114 cattle farms in south west England

Woodbine, Kerry A.; Schukken, Y.H.; Green, Laura; Ramirez-Villaescusa, Ana; Mason, Sarah; Moore, Stephen; Bilbao, Christine; Swann, Natalie; Medley, Graham F.

doi:10.1016/j.prevetmed.2009.02.005

Cited by 51 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to these ongoing recording systems, oneoff surveys are often carried out (Davison et al, 2005;Salimi-Bejestani et al, 2005;Woodbine et al, 2009b); although useful, their results should be interpreted with caution because of issues such as nonprobabilistic selection of studied farms (Paton et al, 1998;Woodbine et al, 2009b;Williams and Winden, 2014) and failure to adjust prevalence estimates for the study design (Paton et al, 1998) or for test performance (Davison et al, 2005;Woodbine et al, 2009a;Williams and Winden, 2014). Furthermore, one-off studies are only useful for a limited period of time, as the prevalence can change as a result of the implementation of control measures and changes in the dairy industry, the more apparent of which are increased herd size, genetic selection, and application of new technological innovations (Barkema et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Velasova

Damaso

Prakashbabu

et al. 2017

Journal of Dairy Science

View full text Add to dashboard Cite

To implement appropriate and effective disease control programs at the national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study was to estimate the prevalence of selected endemic infectious diseases in the population of dairy herds in Great Britain. Bulk milk tank (BMT) samples from 225 randomly selected dairy farms, stratified by region and herd size, were tested for antibodies against bovine viral diarrhea virus (BVDV), bovine herpesvirus type 1, Mycobacterium avium ssp. paratuberculosis, Leptospira Hardjo, Salmonella spp., Coxiella burnetii, Fasciola hepatica, Neospora caninum, and Ostertagia ostertagi. Furthermore, the presence of BVDV, C. burnetii, and Chlamydia-like organisms was determined by PCR. The apparent herd prevalence was estimated as a weighted proportion of positive herds. The true prevalence was calculated when a test was used with known test characteristics for the cut-off value used. Among unvaccinated herds, the true prevalence of BMT antibodies against BVDV was estimated at 66% [95% confidence interval (CI): 56-77%], M. avium ssp. paratuberculosis 68% (95% CI: 59-77%), bovine herpesvirus type 1 62% (95% CI: 52-73%), Leptospira Hardjo 47% (95% CI: 34-60%), and Salmonella spp. 48% (95% CI: 39-56%). The apparent prevalence of BMT antibodies against C. burnetii was 80% (95% CI: 75-85%), F. hepatica 55% (95% CI: 48-62%), N. caninum 46% (95% CI: 38-54%), and O. ostertagi 95% (95% CI: 91-98%). The BVDV, C. burnetii, and Chlamydia-like antigens were detected in 5 (95% CI: 2-9%), 29 (95% CI: 21-36%), and 31% (95% CI: 24-38%) of herds, respectively. Our results show that dairy cows across GB are frequently exposed to the studied pathogens, which are endemic at high levels with some geographical variations. These prevalence estimates provide a muchneeded basis to assess whether nationwide control programs for the studied pathogens are justified by their potential economic, environmental, and public health implications. Should surveillance and control programs be initiated, the estimates presented here are a baseline against which progress can be assessed. Key words: prevalence, endemic infectious disease, dairy cow, bulk milk, ELISA INTRODUCTIONSeveral infectious diseases of dairy cows such as bovine viral diarrhea virus (BVDV), Johne's disease caused by Mycobacterium avium ssp. paratuberculosis (MAP), infectious bovine rhinotracheitis, and liver fluke are generally regarded as being widespread and endemic in the United Kingdom (Carslake et al., 2011;Sekiya et al., 2013). These diseases are known to have a significant effect on dairy production due to their effects on fertility (Fray et al., 2000;Lanyon et al., 2014;Walz et al., 2015), milk production (Tiwari et al., 2007;McAloon et al., 2016), and, subsequently, culling (Murphy et al., 2006;Smith et al., 2010).In Great Britain (GB) in 2005, the total costs of dairy and beef cattle endemic infectious diseases (disease, control, and prevention) were estimated to be as high as £10 million ($12.4 m...

show abstract

Section: Introductionmentioning

confidence: 99%

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Velasova

Damaso

Prakashbabu

et al. 2017

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…It was also determined that paratuberculosis was seen more frequently in cattle aged 5-7 years. In some studies in cattle, paratuberculosis was usually observed in those 2 years old and over (25,26). However, in several studies, positivity was detected in different age groups (15,23).…”

Section: Discussionmentioning

confidence: 99%

Serological and molecular diagnosis of paratuberculosis in dairy cattle

Gümüşsoy¹,

Ica²,

Abay³

et al. 2015

Turk J Vet Anim Sci

View full text Add to dashboard Cite

IntroductionParatuberculosis (Johne's disease), found mainly in cattle, sheep and goats, camels, buffalo, antelope, and deer as well as many domestic and wild animals, is an infectious and contagious disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) (1).MAP, an acido-resistant bacterium previously known as Mycobacterium paratuberculosis and M. johnei, is a member of the M. avium-Mycobacterium intracellular complex. MAP is known as an intracellular, gram-positive, bacterium with thick, short rods (1). It is biochemically weak, does not have any exotoxin, and gives a positive reaction to avian tuberculin (1).The bacteriological examination of stools for paratuberculosis is a helpful diagnostic method for determining healthy animals found in apparently infected herds. Nowadays, the most reliable method for the diagnosis of paratuberculosis from live animals is the fecal culture method (1). In addition, by using polymerase chain reaction (PCR) and real-time PCR methods, diagnosis can be performed faster (2).Animals with paratuberculosis shed viable MAP agents, especially in their milk. MAP may have a role in

show abstract

“…The results of the present study revealed that the prevalence was higher in older age groups, i.e., >10 years old as compared with 1-5 years age group. A prevalence based study in England was conducted by Woodbine et al (2009) which revealed that old animals were more prone to disease than the young ones. The gross findings showed that 1.25% nulliparous females were suspected for Paratuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Pathology of Paratuberculosis in Cattle and Buffaloes at Faisalabad Abattoir

Rehman¹

2017

PAKJAS

View full text Add to dashboard Cite

Bovine Paratuberculosis is a chronic, debilitating disease resulting in huge economic losses to the dairy industry. The present study was conducted to determine the frequency of Paratuberculosis infection in cattle and buffaloes slaughtered at Faisalabad abattoir, Pakistan. The study carried out on a total of 400 animals including cattle (200) and buffaloes (200). On the basis of PCR, 0.5% buffaloes and 1.5% cattle were found positive for Paratuberculosis. From 25 cattle and 20 buffaloes the suspected morbid samples of intestine and mesenteric lymph nodes were collected and were further processed for histopathology analysis and molecular characterization using polymerase chain reaction techniques (PCR). A total of 18 cases of intestine showed haemorrahages, out of these 2 cases showed thickened mucosa and corrugation. These samples were further processed for histopathology and PCR. The results revealed that out of 45 morbid samples (25 cattle + 20 buffaloes), 4 were confirmed by PCR for Mycobacterium Paratuberculosis. The histopathology examination of intestine tissues revealed diffuse inflammatory reaction, mononuclear cell infiltration along with degenerative and necrotic changes in sub-mucosal glands of the intestine. The immature granuloma formation was also observed in both intestine and lymph nodes.The study concluded that the disease was prevalent (1%) in animals coming for slaughtering at Faisalabad abattoir.

show abstract

Seroprevalence and epidemiological characteristics of Mycobacterium avium subsp. paratuberculosis on 114 cattle farms in south west England

Cited by 51 publications

References 26 publications

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Serological and molecular diagnosis of paratuberculosis in dairy cattle

Prevalence and Pathology of Paratuberculosis in Cattle and Buffaloes at Faisalabad Abattoir

Contact Info

Product

Resources

About