Seroprevalence and geographical distribution of human T-lymphotropic virus type 1 among volunteer blood donors in endemic areas of Iran

Karimi, Gharib; Zadsar, Maryam; Pourfathollah, Ali Akbar

doi:10.1186/s12985-017-0693-9

Cited by 22 publications

(25 citation statements)

References 27 publications

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“…The current study revealed that the frequency of HTLV-1 infection was much higher among the donor population in Mashhad than that of other cities. This finding is in agreement with the previous reports on the HTLV endemicity in the region (16,17). Our previous study (2009) demonstrated that the prevalence of HTLV infection was 2.2% in the general population of Mashhad (15).…”

Section: Discussionsupporting

confidence: 94%

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

2019

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Background: Mashhad is a large pilgrimage city with over 20 million pilgrims and tourists annually. Some pilgrims donate their blood voluntarily during the pilgrimage. Objectives: The present study aimed to compare the prevalence of viral transfusion-transmitted infections (TTIs) between resident and pilgrim blood donors in Mashhad. Methods: We reviewed the records of all blood donors in Mashhad blood centers in 2011. The demographic data and the prevalence of TTIs, including HBV, HCV, HIV, and HTLV-1, were compared between 42821 donors from Mashhad and 15219 donors from other cities of Iran. The data were analyzed using Microsoft Excel 2010 and Epi-Info 6.0 software. Results:The mean age of residents and pilgrims was 34.6 ± 9.9 and 34.2 ± 10 years, respectively. The male to female ratio in the first group was higher than that in the second group (13.1 and 6.6, respectively). One-third of the residents and nearly two-thirds of the pilgrims were first-time blood donors. The most prevalent TTIs among the residents were HTLV-1 (0.39%) and HBV (0.33%); however, the frequencies of these infections were 0.24% and 0.57% among the pilgrims, respectively. The seroprevalence of HCV infection was 0.054% and 0.072% in the first and second groups, respectively. The HIV infection was observed only in one donor from Mashhad. Conclusions: A low prevalence of TTIs, particularly HCV and HIV infections, was found among blood donors from all parts of Iran. A higher prevalence of HTLV-1 infection among Mashhad donor population than among donors from other parts of Iran verified the virus endemicity in this region.

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Section: Discussionsupporting

confidence: 94%

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

2019

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“…In Japan, this may be caused by the natural decrease of HTLV‐1 infection due to the effects of the HTLV‐1 screening program for pregnant women and the shortening of the breastfeeding period in Japan in recent decades. However, recent studies in the United States and Iran also showed a natural decline of HTLV‐1 seroprevalence in each country. These natural declines can be explained by a birth‐cohort effect .…”

Section: Discussionmentioning

confidence: 99%

Fine‐scale geographic clustering pattern of human T‐cell leukemia virus type 1 infection among blood donors in Kyushu‐Okinawa, Japan

Sagara

Iwanaga

Morita

et al. 2018

Journal of Medical Virology

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Human T‐cell leukemia virus type I (HTLV‐1) infection is endemic in Japan, particularly clustered in the southwestern district, Kyushu‐Okinawa, which consists of eight prefectures that further consist of 274 municipalities. However, no information is available about the fine‐scale distribution of HTLV‐1 infection within Kyushu‐Okinawa. To assess the municipal‐level distribution of people with HTLV‐1 infection in Kyushu‐Okinawa, we performed a cross‐sectional study using a fine‐scale geographic information system map based on HTLV‐1 screening test results from the Japanese Red Cross database from September 2012 to February 2014. Of the 881 871 (646 914 male, 234 957 female) screened blood donors, 981 were seropositive for HTLV‐1 by confirmatory test. The seroprevalence was 0.11% (95% confidence interval [CI] 0.10%‐0.12%) for all, 0.094% (95% CI, 0.09%‐0.10%) for male, and 0.16% (95% CI, 0.14%‐0.18%) for female individuals. The sex‐ and age‐specific HTLV‐1 seroprevalence varied significantly across municipalities; particularly, the seroprevalence among women aged 50 years was significantly higher than that of men in both the mainland of Kyushu‐Okinawa and the satellite island, in all of which the seroprevalence of HTLV‐1 was more than 1.2%. These results show that, even in the Kyushu‐Okinawa district, there are endemic clusters of HTLV‐1 in small areas. This suggests that public health education programs are needed to eliminate new HTLV‐1 infection in these areas.

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“…During two successive years (From March 2011 to April 2013), Hatami et al (28) showed the prevalence of HTLV-1 was 0.5% among blood donor females (aged 17 to 59) in Mashhad. About 1864489 blood donations were evaluated for HTLV-1 by karimi et al, and there were 0.098% infected donators (29).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Human T-cell Leukemia Virus Antibodies among Young Females Attending a Large Medical Diagnostic Laboratory in Neyshabour, Northeast of Iran, During 2011 to 2015

Mobini

Salehi

2018

Arch Clin Infect Dis

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Background:Human T-Cell Leukemia Virus (HTLV) infection is endemic in Neyshabour, and even higher than other cities. Objectives: The aim of this investigation was to determine the prevalence of HTLV antibodies among young females attending a large medical diagnostic laboratory in Neyshabour, during 2011 to 2015. Methods: The researchers established this study by data, which were collected from the surveillance system. Based on HTLV-1 and HTLV-2 ELISA kit instruction, 5724 females were evaluated. Variables were age, year, and season. Data were analyzed by the SPSS software. Results: According to the Enzyme Linked Immunosorbent Assay (ELISA) results, 117 (2.04 %) young females indicated evidence of antibodies to HTLV-1 and HTL -2. Most infected young females were aged 38 to 39 years (4.16%) and according to annual prevalence, the highest rates were found in 2012. Also, most infected young females had referred in October (3.16%). Conclusions:The data obtained suggests that Neyshabour is a high endemic city of HTLV infected young females. Making them aware seems to be vital in avoiding transfer of HTLV infection, especially to the next generation. However, further investigations like population-based studies are required to confirm these results

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Seroprevalence and geographical distribution of human T-lymphotropic virus type 1 among volunteer blood donors in endemic areas of Iran

Cited by 22 publications

References 27 publications

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

Frequency of Viral Transfusion-Transmitted Infections (TTIs) Among Resident and Pilgrim Blood Donors in Mashhad, 2011

Fine‐scale geographic clustering pattern of human T‐cell leukemia virus type 1 infection among blood donors in Kyushu‐Okinawa, Japan

Prevalence of Human T-cell Leukemia Virus Antibodies among Young Females Attending a Large Medical Diagnostic Laboratory in Neyshabour, Northeast of Iran, During 2011 to 2015

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