Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China

Li, Yang; Zhang, Xingcan; Zhang, Yue; Wei, Minqi; Tao, Sijie; Yang, Ying‐Fei

doi:10.1186/s12879-023-08028-y

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…In a recent Chinese study among 520 individuals more male sex partners, lower income and being a student were associated with higher seropositivity for HHV-8. In addition being coinfected with hepatitis C virus and syphilis resulted in higher risk for seropositivity [9]. This higher seropositivity has been attributed to the more frequent use of saliva as a lubricant in homosexual practices as saliva is the main HHV-8 focus [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Case Series of Kaposi Sarcoma in HIV-Negative MSM

N.T.,

B.,

et al. 2024

J Dermatol Res Ther

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Kaposi sarcoma (KS) is a tumor originating from endothelial cells, both vascular and lymphatic, and is associated with human herpesvirus 8 (HHV-8). Four distinct KS subtypes have been defined: Classic, endemic, iatrogenic, and epidemic or acquired immunodeficiency syndrome (AIDS)-related KS. More recently a fifth subtype has been recognized in men having sex with men (MSM) in the absence of human immunodeficiency virus (HIV) infection.We report here on three cases of KS in HIV-negative MSM and review the literature. Two patients were treated with topical propranolol, with a partial response in one. One patient was treated with pegylated liposomal doxorubicin because of lymphoedema. There was clinical improvement with regression/flattening of multiple lesions as well as symptom relief. Further research into this fifth subtype of KS is warranted as its exact pathogenesis is currently unclear.

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Section: Discussionmentioning

confidence: 99%

Case Series of Kaposi Sarcoma in HIV-Negative MSM

N.T.,

B.,

et al. 2024

J Dermatol Res Ther

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“…For extensive disease, a combination of surgery, chemotherapy and radiation is advocated. Some recent therapeutic agents such as imatinib and matrix metalloproteinase inhibitors are also being tried 27 , 28 , 29 and some antiviral agents including ganciclovir, foscarnet, valganciclovir and cidofovir have been shown to have some therapeutic effects via inhibiting HHV‐8. 30 , 31 However, the best therapeutic approach for KS lesions in setting of PV is still remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Kaposi's sarcoma in a patient with pemphigus vulgaris mimicking exacerbation of pemphigus

et al. 2023

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Background Kaposi's sarcoma (KS) is a rare multifocal angiogenic tumor often seen in immunocompromised setting such as acquired immunodeficiency syndrome (AIDS) or organ transplantation recipients. Pemphigus vulgaris (PV) is a rare blistering disorder with mucocutaneous involvement for which immunosuppressive therapy has long been the core of treatment. Iatrogenic form of KS has been reported infrequently in pemphigus patients as a result of long‐term immunosuppressive therapy. Case We describe a 39‐year‐old male patient with confirmed diagnosis of PV who developed KS after receiving immunosuppressive agents for his pemphigus. KS was initially localized to the oral cavity with features mimicking exacerbation of his pemphigus. Conclusion This interesting case of KS suggests that dermatologists visiting patients with pemphigus with discomfort in the oral cavity should have a high degree of awareness and consider other differential diagnoses along with merely an exacerbation of PV.

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“…Notably, earlier studies have found increased risk of KS also in MSM without HIV [ 25 , 26 ]. This may reflect a high seroprevalence of HHV-8 among MSM [ 27 ], which has been associated with high-risk sexual behavior and multiple sexual partners [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Extracutaneous Kaposi sarcoma risk remains higher in people with HIV in the post-ART era: a nation-wide population-based study

Dinh

Malmström

Møller

et al. 2023

Aids

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Objective: To assess Kaposi sarcoma (KS) by HIV-status in Sweden 1983–2017, with particular focus on extracutaneous KS. Design: Population-based study linking the Total Population Registry, the Swedish HIV Registry InfCareHIV, and the Swedish Cancer Registry. Methods: We included all Swedish residents, born in or outside Sweden between 1940 and 2000 (n = 8 587 829), assessing the annual incidence of KS, adjusted hazard ratios (adjHR), and odds ratios (adjOR) in the pre- and post-combination antiretroviral therapy (ART) eras. Results: KS was found in 324 individuals of whom 202 (62%) were people living with HIV (PLHIV). While the incidence of KS decreased in PLHIV, it remained higher compared to HIV-negative at end of follow-up (28 vs. 0.09 per 100 000 person-years, p < 0.001). In the post ART era PLHIV still had an increased risk of both cutaneous (adjHR 616, 95% confidence interval [CI] 410–926) and extracutaneous KS (adjHR 2068, 95% CI 757–5654), compared to HIV-negative individuals, although there were no cases of extracutaneous disease among virally suppressed PLHIV. In the post-ART era, the relative risk for KS remained higher in men, particularly MSM, and viral suppression was associated with lower odds of KS (adjOR 0.05, 95% CI 0.03–0.09). Conclusions: KS remained increased in PLHIV in the post-ART era, with a particularly high risk for extracutaneous disease compared to HIV-negative individuals. Notably, there were no cases of extracutaneous disease among virally suppressed PLHIV, suggesting a less aggressive disease in this population. Further studies on KS in virally suppressed PLHIV are warranted.

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Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China

Cited by 3 publications

References 39 publications

Case Series of Kaposi Sarcoma in HIV-Negative MSM

Case Series of Kaposi Sarcoma in HIV-Negative MSM

Kaposi's sarcoma in a patient with pemphigus vulgaris mimicking exacerbation of pemphigus

Extracutaneous Kaposi sarcoma risk remains higher in people with HIV in the post-ART era: a nation-wide population-based study

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