Seroprevalence and risk factors for cytomegalovirus infection among pregnant women in southern Nigeria

Emovon, Ephraim Ogbaini

doi:10.5799/ahinjs.02.2013.03.0094

Cited by 11 publications

(13 citation statements)

References 29 publications

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“…This is in agreement with studies in other region; 4 % in Nigeria [41], 8.1 % in Kenya [19], 6 % in Sudan [40]. However, our finding is in contrast with other studies in similar setting [39] and 2.5 % in Iran [43], 1.7 % in Korea [44].…”

Section: Discussionsupporting

confidence: 91%

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Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

et al. 2016

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BackgroundMaternal cytomegalovirus (CMV) and Rubella infections result in adverse neonatal outcomes. Both CMV and Rubella are more widespread in developing countries and in communities with lower socioeconomic status. Thus, the aim of this study was to determine IgM specific to CMV and Rubella among newborns and Maternal CMV-seroprevalence and to identify risk factors.Method and findingUsing cross sectional study design a total of 312 (156 newborns and 156 mothers) study participants were recruited by simple random sampling technique from gynecology outpatient department (OPD) and ward, starting from April 1, 2015 to June 30, 2015. Cord and venous blood samples were collected from all participants and structured questionnaire was introduced to gather risk factor related data. ELISA was used to detect CMV and Rubella-IgM. SPSS version 20 was used to analyze the data, and regression analysis was also performed. Out of 156 newborns, 2 [1.3 %; 95 % CI: 0.0–3.8] were positive for CMV—IgM and no single rubella was detected. Association was not computed between risk related variables and cytomegalovirus infected newborns due to the low positivity rate. Multiple independent predictors were found between maternal CMV-IgM and Obstetrical characteristics. Cytomegalovirus—IgM was significantly isolated from mothers with history of transfusion (25.0 %, OR 0.09, 95 % CI 0.0–0.3, P = 0.006), history of abortion (OR 0.02, 95 % CI 0.0–0.6, P = 0.023), HIV sero-status (OR 5.0, 95 % CI 1.5–15.8, P = 0.034), and multi parity (OR 0.08, 95 % CI 0.01–0.7, P = 0.022).ConclusionAlthough low congenital CMV and no Rubella are reported among newborns, more effort is needed to screen for congenital infectious viral disease as well as usage of advanced techniques should be taken into consideration.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2274-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

“…In this study the maternal prevalence of anti-CMV IgG was 95.5 %, which is comparable with other research findings in a similar setting [39] and different studies in developing countries such as; 77.3 % in Kenya [19], 97.5 % in Sudan [40], 96 % in Egypt [21], 92 % in Nigeria [41], and 87 % in Gambia [42]. …”

Section: Discussionsupporting

confidence: 90%

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

et al. 2016

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“…In a study on CMV prevalence, the highest number of respondents, attending antenatal clinics in their centre was that of younger pregnant women [2,19]. This is similar to our finding and can be explained by the fact that the studies were done in the same geographic region with similar socio-cultural practices and religious believe.…”

Section: Discussionsupporting

confidence: 88%

“…The high prevalence of 94.3% for CMV IgG in our study is also worrisome, and this is the case with many of the studies from the region [19,21].…”

Section: Discussionsupporting

confidence: 57%

Assessment of Some Key Haematological Parameters on Cytomegalovirus Antibody Positive Pregnant Women in Makurdi Nigeria

Michael

Theresa

Olusayo

et al. 2017

IBRR

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Background: There is high prevalence of Cytomegalovirus (CMV) in pregnancy worldwide, primary infection in particular has been associated with significant haematological changes and childhood neurodevelopmental disabilities. There is however, paucity of information on the effect of CMV seropositivity in pregnancy on the haematological parameters of pregnant women from our centre. Aim: This study was therefore designed to determine the effects of CMV sero-positivity among pregnant women, in Makurdi Nigeria, on some key haematological parameters. Methods: A cross sectional study of 211 pregnant women aged 15-50 years attending antenatal clinic at

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“…On the other hand, our result showed a high CMV IgG seropositivity of 94.6% in multiparous women. However, high parity also has been implicated as associated risk factor for CMV infection, and previous studies suggested a positive correlation of congenital CMV with a household size, overcrowding, and low socioeconomic status [23].This high seroprevalence rate among multiparous women could be related to the unhygienic practices in large sized family and direct contact with infected children [29].…”

Section: Discussionmentioning

confidence: 97%

Seroprevalence of Cytomegalovirus Among Pregnant Women in Ad-Dhale'e City - Yemen

Binsaad

Taleb

2022

Electron. J. Univ. Aden Basic Appl. Sci.

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This study aimed to determine the seroprevalence of Cytomegalovirus virus (CMV) infection among pregnant women in Ad Dhale'e city, Yemen. A cross-sectional study was conducted among 130 pregnant women attended for routine antenatal care in Al-Nasser hospital in Ad-Dhale'e city. Serum was obtained and tested for seropositivity of CMV IgG and IgM using electro-chemiluminescence immunoassays (ECLIA) test. Of 130 blood sample, 122 (93.8 %) and 5 (3.8%) were identified with CMV IgG and CMV IgM seropositive respectively. While, 8 (6.2%) were seronegative (susceptible) to CMV infection. Statistically significant association (P< 0.05) was found between CMV IgG seropositivity and age. This study concluded that there was high seroprevalence of cytomegalovirus infections among pregnant women in Ad-Dhale'e city. Routine antenatal screening of pregnant women for CMV infection should be considered. Further studies with more sample size using advanced methods is recommended.

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Seroprevalence and risk factors for cytomegalovirus infection among pregnant women in southern Nigeria

Cited by 11 publications

References 29 publications

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

Assessment of Some Key Haematological Parameters on Cytomegalovirus Antibody Positive Pregnant Women in Makurdi Nigeria

Seroprevalence of Cytomegalovirus Among Pregnant Women in Ad-Dhale'e City - Yemen

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