Seroprevalence and trend of hepatitides among blood donors in a district hospital in Ghana: a nine-year retrospective, descriptive cross-sectional study

Nkansah, Charles; Serwaa, Dorcas; Osei‐Boakye, Felix; Owusu-Ampomah, Richard

doi:10.1080/15321819.2019.1682601

Cited by 13 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is consistent with studies conducted in Ethiopia and other countries. 11,31,46 Participants who had a family history of hepatitis infection were 5.2 times more likely to be infected with HBV (p < 0.05) and it was found to be an independent risk factor and supported by other studies conducted in Ethiopia, 8,11,48 and other African countries. 14,19,25 This indicates that the main root for transmission of HBV is cross-contamination of body fluids; hence, this could explain the presence of close contact with hepatitis patients or sexual contact increases the chance of HBV transmission.…”

Section: Discussionsupporting

confidence: 66%

Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia

Beykaso¹,

Teklehaymanot²,

Giday³

et al. 2021

RMHP

View full text Add to dashboard Cite

Screening of viral transfusion-transmissible infections (TTIs) among blood donors is of public health concern. It is a cost-effective method to monitor the occurrence, distribution, and trends of TTIs in healthy people. This study aimed to estimate the magnitude of the three common viral TTIs among blood donors in Hossana, Ethiopia. Methods: A cross-sectional study was conducted among 417 blood donors from April to May 2020 in Southern Ethiopia. Data were collected using a structured questionnaire and laboratory blood screening for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) using Wantai AiDTM HBsAg, anti-HCV, and HIV 1 + 2 Ag/ Ab ELISA. Data were entered into Epi-Data version 3.1 and analyzed using SPSS version 21.0. A binary logistic regression model was fitted to identify factors associated with each viral infection. The odds ratio with a 95% confidence interval was calculated. A p-value <0.05 was considered statistically significant. Results: A total of 417 blood donors participated in this study producing an overall prevalence of viral TTI was 14.38%. HBV, HCV, and HIV prevalence were 9.83%, 2.39%, and 4.31%, respectively. HBV-HIV was a common co-infection, which had 1.2%. In multivariate logistic regression analysis, family history of hepatitis (AOR=5.2, 95% CI (2.92, 7.41)) and multiple sexual contacts (AOR=4.2, 95% CI (2.32-7.43)) were significantly associated with HBV; low educational level (AOR=3.1, 95% ) and multiple sexual contacts (AOR=4.9, 95% CI (3.51-7.96)) were significantly associated with HIV, but the only variable alcohol consumption (AOR=2.7, 95% CI (6.72-23.76)) was also associated with HCV infection. Conclusion:In this study, the magnitude of viral TTIs among blood donors is high. This indicates that there are high risks of transmission for these infectious pathogens. Therefore, effective stringent donor selection and screening protocols should be developed.

show abstract

Section: Discussionsupporting

confidence: 66%

Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia

Beykaso¹,

Teklehaymanot²,

Giday³

et al. 2021

RMHP

View full text Add to dashboard Cite

show abstract

“…The blood donors in this study were predominantly males (88.1%), with a male to female ratio of 7:1. This was consistent with ndings of other studies in Ghana [11] and Mali [17]. Nkansah et al, [11] inferred that the high turnout of male donors is attributed to the fact that a lot of males meet the standards for blood donor and further used this to justify the increased population of younger However, the basis for the reduced level of female participation in blood donation is suggested to be the result of peculiarities associated with the female gender; according to some studies, obstetric factors like menstruation [18] [19][20], childbearing [18] [19][20][21], and lactation [18] [20][21] lead to increased deferral of females, making males more suitable candidates [19].…”

Section: Insert Figure 1 Discussionsupporting

confidence: 94%

Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana

Osei‐Boakye

Nkansah

Appiah

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background Hepatitis B and C cause chronic infections which develop into liver-related sequelae, like cirrhosis and liver carcinoma. This study determined the prevalence, trends, and risk factors of HBV and HCV among family replacement blood donors. Methods A retrospective review of primary data on blood donors screened between January 2015 and December 2021 was conducted at the Sunyani Municipal Hospital. The data were assessed for seroprevalence, trends, and odds ratios using SPSS. Results Of 6847 donors, the majority were males (88.1% [6033]), ≤ 24 years (27.4% [1874]), of the O blood type (69.8% [4776]), and Rh-positive (89.9% [6154]). Seroprevalences of HBV and HCV were 3.2% and 1.9%, respectively, with more males infected with both HBV and HCV (3.4% vs 2.0%). Male donors were 2.842 times (CI: 1.500-5.385, p = 0.001) and 2.399 times (CI: 1.116–5.157, p = 0.025) more susceptible than females to HBV and HCV, respectively. In the rainy season, donors were 1.489 times (CI: 1.017–2.180, p = 0.041) more susceptible to HCV. HBV and HCV showed declining trends over the period (slope: -0.5464, p ≤ 0.001 vs slope: -0.6179, p ≤ 0.001). Conclusion Gender was significantly associated with both HBV and HCV, while season was significantly associated with HCV. The male gender and rainy season were significant determinants of both infections. The seroprevalence of HBV was higher than HCV despite the significant decline in both HBV and HCV seroprevalences. We, recommend health authorities intensify health education among males and during the rainy season. Also, local variations in the seroprevalence of these infections call for upgrade and standardisation in serological testing for blood donors across Ghanaian blood centres.

show abstract

“…The assay qualitatively detects the presence of HCV antibodies and surface antigens of HBV (HBsAg). The algorithms used for routinely testing HBV and HCV in blood banks in Ghana have been described by Nkansah et al, [11].…”

Section: Screening Of Blood Donorsmentioning

confidence: 99%

“…In Ghana, blood donors undergo screening to exclude infected donors, however, the screening may be insu ciently done due to limited resources [11] and this may pose a signi cant health risk to blood recipients. The burden of HBV and HCV in Ghana is fragmented and varies from one place to the other, with some [12] [13] showing local variations.…”

Section: Introductionmentioning

confidence: 99%

“…The burden of HBV and HCV in Ghana is fragmented and varies from one place to the other, with some [12] [13] showing local variations. Although several studies [11][12] [14] conducted in Ghana reported on the prevalence, and trends of HBV and HCV, they failed to determine the risk factors of these infections. Furthermore, a similar study conducted by Walana et al,[8] in the Bono Region focused only on the prevalence of HBV while no attention was accorded to HCV despite its association with severe liver-related diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana

Osei‐Boakye

Nkansah

Appiah

et al. 2023

Journal of Immunoassay and Immunochemistry

Self Cite

View full text Add to dashboard Cite

BackgroundHepatitis B and C cause chronic infections which develop into liver-related sequelae, like cirrhosis and liver carcinoma. This study determined the prevalence, trends, and risk factors of HBV and HCV among family replacement blood donors. MethodsA retrospective review of primary data on blood donors screened between January 2015 and December 2021 was conducted at the Sunyani Municipal Hospital. The data were assessed for seroprevalence, trends, and odds ratios using SPSS. ResultsOf 6847 donors, the majority were males (88.1% [6033]), ≤ 24 years (27.4% [1874]), of the O blood type (69.8% [4776]), and Rh-positive (89.9% [6154]). Seroprevalences of HBV and HCV were 3.2% and 1.9%, respectively, with more males infected with both HBV and HCV (3.4% vs 2.0%). Male donors were 2.842 times (CI: 1.500-5.385, p = 0.001) and 2.399 times (CI: 1.116-5.157, p = 0.025) more susceptible than females to HBV and HCV, respectively. In the rainy season, donors were 1.489 times (CI: 1.017-2.180, p = 0.041) more susceptible to HCV. HBV and HCV showed declining trends over the period (slope: -0.5464, p ≤ 0.001 vs slope: -0.6179, p ≤ 0.001). ConclusionGender was signi cantly associated with both HBV and HCV, while season was signi cantly associated with HCV. The male gender and rainy season were signi cant determinants of both infections. The seroprevalence of HBV was higher than HCV despite the signi cant decline in both HBV and HCV seroprevalences. We, recommend health authorities intensify health education among males and during the rainy season. Also, local variations in the seroprevalence of these infections call for upgrade and standardisation in serological testing for blood donors across Ghanaian blood centres.

show abstract

Seroprevalence and trend of hepatitides among blood donors in a district hospital in Ghana: a nine-year retrospective, descriptive cross-sectional study

Cited by 13 publications

References 16 publications

Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia

Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia

Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana

Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana

Contact Info

Product

Resources

About