Séroprévalence et facteurs associés au VIH et aux hépatites virales B et C dans la ville de Bafoussam au Cameroun

Mbopi-Kéou, François-Xavier; Nkala, Isabelle Vanessa Monthe; Kalla, Ginette Claude Mireille; Nguefack‐Tsague, Georges; Kamga, Hortense Gonsu; Noubom, Michel; Mvogo, Côme Ebana; Sosso, Maurice Aurélien

doi:10.11604/pamj.2015.20.156.4571

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…This result is higher than the 4.1% recorded by Mbopi-keou et al . [ 17 ] in a study conducted in Bafoussam, Cameroon. This disparity can be justified by the difference in the population studied, of which those in the present one were mostly students who are more likely to be vulnerable to unsafe sexual practices.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Tadongfack¹,

Keubo²,

Bianke³

2020

Pan Afr Med J

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Introduction viral hepatitis B remains a major public health problem around the world, especially in underdeveloped and developing countries. Cameroon shows a grate variability in prevalence of this infection in the country and even within different populations groups. The aim of this study was to determine the prevalence and factors associated with viral hepatitis B infection in the rural area of Dschang. Methods we conducted a cross-sectional community-based study, involving 551 participants of both genders recruited by a voluntary sampling technique. The biological diagnosis of HBsAg was done by the Immunochromatographic method (PKL® kit of PARAMEDICAL srl laboratories). Positive cases were confirmed by ELISA method (reagent Kit from DIALAB Laboratories). Results results show a Viral Hepatitis B prevalence of 5.08% (95% CI: 3.2-6.9). University students were the most infected (11/88) with a positivity rate of 12.50% (95%CI: 5.6-19.4). Only 29/551 participants (5.26%) had received at least one dose of vaccine against the disease and were less infected (3.44%) than the others (5.17%). Age (p=0.000), level of education (p=0.013), occupation (p = 0.002), belief in the traditional healing of hepatitis B (p=0.000) and knowledge about the disease and its contamination roads (p=0.049) were associated with viral hepatitis B. Conclusion there is a need of intensifying awareness, education, routine screening and vaccination of the population, especially in schools and university milieu to better counteract the infection with hepatitis B virus in our local Communities.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Tadongfack¹,

Keubo²,

Bianke³

2020

Pan Afr Med J

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“…Previous studies also found an association between HIV status and these diseases [15][16][17]. STIs play a major role in the sexual transmission of HIV.…”

Section: Discussionmentioning

confidence: 73%

Seroprevalence of HIV Infection and Associated Factors Among Newly Incarcerated Prisoners in Abidjan, Ivory Coast

Purifine¹

2017

SJPH

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Abstract:Poor socio-economic condition of prisoners and practices at risk of getting transmissible diseases in most prisons contribute to the spread of Human Immunodeficiency Virus (HIV) infection. The objectives of this study were to determine HIV seroprevalence among newly incarcerated persons, to describe their risk behaviors, and to identify factors associated with HIV infection. We conducted a cross-sectional study from January 2014 to February 2014 at the biggest prison of Abidjan called "House of Judgement and Correction of Abidjan" (HJCA). Study population included newly incarcerated persons aged more than 18 years. Overall, 370 people were included after an informed consent. Findings showed that 13% of inmates used drug; 8.3% of them using injectable drugs. The vast majority of respondents (97.3%) experienced sexual intercourse and 31.9% had multiple sexual partners. More than half (50.6%) of respondents did not use condom, and among those who use it, 73.6% used it irregularly. During their last sexual intercourse, 71.8% of respondents did not use condom. Overall, 7.9% of respondents were HIV positive. Factors associated with HIV positive status were history of herpes zoster (adj. OR=16.66, 95% CI: 2.66-104.08, p=0.003), history of STIs (adj. OR=8.82, 95% CI: 3.25-23.95, p<0.001), history of tuberculosis (adj. OR=6.49, 95% CI: 1.06-39.79, p=0.043), and having had more than one sexual partner over the last 12 months (adj. OR=8.11, 95% CI: 1.75-37.51, p=0.007). Promoting safer behaviors, routine HIV screening among prisoners, care for HIV-positive people, and improved living conditions in prisons are needed measures to control HIV / AIDS in prison environment in Ivory Coast.

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“…HCVAb seroprevalence in Cameroon varies across regions and tribes within the same country. While some studies reported high HCVAb carriage: in the southern 12% [ 34 ], in the western 6.3% [ 35 ], numerous studies on the contrary revealed a relative much lower prevalence: 2.2% anti-HCV in the Northern [ 27 ], 0.6% in the eastern [ 36 ], 0.4% in the western [ 37 ], 4.8% in the Littoral Region [ 38 ], 1.44% in the center region [ 39 ]. Equally, various burden of anti-HCV antibodies have also been reported in community settings worldwide: 0.77% in Romania [ 40 ], 1.02% in Sudan [ 41 ], 1.2% in Madagascar [ 42 ], 2.4%in Iraq [ 43 ], 3.6% in India [ 44 ], 19.80% in Cairo [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-hepatitis C antibody carriage and risk of liver impairment in rural-Cameroon: adapting the control of hepatocellular carcinoma for resource-limited settings

Kamga Wouambo,

Panka Tchinda,

Kagoue Simeni

et al. 2023

BMC Infect Dis

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Background The Viral hepatitis elimination by 2030 is uncertain in resource-limited settings (RLS), due to high burdens and poor diagnostic coverage. This sounds more challenging for hepatitis C virus (HCV) given that antibody (HCVAb) sero-positivity still lacks wide access to HCV RNA molecular testing. This warrants context-specific strategies for appropriate management of liver impairment in RLS. We herein determine the association between anti-HCV positivity and liver impairment in an African RLS. Methods A facility-based observational study was conducted from July-August 2021 among individuals attending the “St Monique” Health Center at Ottou, a rural community of Yaounde,Cameroon. Following a consecutive sampling, consenting individuals were tested for anti-HCV antibodies, hepatitis B surface antigen (HBsAg) and HIV antibodies (HIVAb) as per the national guidelines. After excluding positive cases for HBsAg and/or HIVAb, liver function tests (ALT/AST) were performed on eligible participants (HBsAg and HIVAb negative) and outcomes were compared according to HCVAb status; with p < 0.05 considered statistically significant. Results Out of 306 eligible participants (negative for HBsAg and HIVAb) enrolled, the mean age was 34.35 ± 3.67 years. 252(82.35%) were female and 129 (42.17%) were single. The overall HCVAb sero-positivity was 15.68%(48/306), with 17.86% (45/252) among women vs. 5.55%(3/54) among men [OR (95%CI) = 3.69(2.11-9.29),p = 0.04]. HCVAb Carriage was greater among participants aged > 50 years compared to younger ones [38.46%(15/39) versus 12.36% (33/267) respectively, OR(95%CI) = 4.43(2.11-9.29), p < 0.000] and in multipartnership [26.67%(12/45)vs.13.79%(36/261) monopartnership, OR (95%CI) = 2.27(1.07-4.80),p = 0.03]. The liver impairment rate (abnormal ALT+AST levels) was 30.39%(93/306), with 40.19%(123/306) of abnormal ALT alone. Moreover, the burden of Liver impairment was significantly with aged> 50 versus younger ones [69.23% (27/39) versus 24.72%(66/267) respectively, p < 0.000). Interestingly, the burden of liver impairment (abnormal AST + ALAT) was significantly higher in HCVAb positive (62.5%, 30/48) versus HCVAb negative (24.42%, 63/258) participants, OR: 3.90 [1.96; 7.79], p = 0.0001. Conclusions In this rural health facility, HCVAb is highly endemic and the burden of liver impairment is concerning. Interestingly, HCVAb carriage is associated with abnormal liver levels of enzyme (ALT/AST), especially among the elderly populations. Hence, in the absence of nuclei acid testing, ALT/AST are relevant sentinel markers to screen HCVAb carriers who require monitoring/care for HCV-associated hepatocellular carcinoma in RLS.

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Séroprévalence et facteurs associés au VIH et aux hépatites virales B et C dans la ville de Bafoussam au Cameroun

Cited by 6 publications

References 13 publications

Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Seroprevalence of HIV Infection and Associated Factors Among Newly Incarcerated Prisoners in Abidjan, Ivory Coast

Anti-hepatitis C antibody carriage and risk of liver impairment in rural-Cameroon: adapting the control of hepatocellular carcinoma for resource-limited settings

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