Seroprevalence of antibodies to cytomegalovirus in pregnant women in the Apulia region (Italy)

Trombetta, Claudia Maria; Viviani, Simonetta; Montomoli, Emanuele; Marchi, Serena

doi:10.15167/2421-4248/jpmh2021.62.2.1800

Cited by 4 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some cases, CMV was detected consistently over time in the plasma of certain women, and this could argue for the free circulation of reactivated virus [44,45]. All these above-mentioned observations support the role of screening against CMV infection in pregnant women and the implementation of hygienic measures to reduce congenital infection [43].…”

Section: Introductionmentioning

confidence: 69%

“…Vertical transmission is higher in primary than in non-primary infection [21] and in the third trimester compared to the first trimester of pregnancy [43]. The severity of fetal lesions and long-term disabilities is higher after first-trimester congenital infection [43] Studies from pregnant women and umbilical cord plasma showed the presence of CMV genome [44]. In some cases, CMV was detected consistently over time in the plasma of certain women, and this could argue for the free circulation of reactivated virus [44,45].…”

Section: Introductionmentioning

confidence: 95%

“…CMV primary and non-primary infections in pregnant women represent important health issues because congenital CMV infection may lead to neurosensorial hearing loss and other fetal disabilities. However, there is no consensus regarding screening for CMV infection in pregnant women; some countries recommend it [4] and others do not [43]. Vertical transmission is higher in primary than in non-primary infection [21] and in the third trimester compared to the first trimester of pregnancy [43].…”

Section: Introductionmentioning

confidence: 99%

“…However, there is no consensus regarding screening for CMV infection in pregnant women; some countries recommend it [4] and others do not [43]. Vertical transmission is higher in primary than in non-primary infection [21] and in the third trimester compared to the first trimester of pregnancy [43]. The severity of fetal lesions and long-term disabilities is higher after first-trimester congenital infection [43] Studies from pregnant women and umbilical cord plasma showed the presence of CMV genome [44].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

Mocanu,

Stoian,

Daescu

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Cytomegalovirus (CMV), a DNA virus that belongs to the Orthoherpesviridae family, infects 40–100% of people. Primary/non-primary CMV infection during pregnancy could cause fetal disabilities. After primary infection, CMV causes a latent infection and resides in cells of the myeloid compartment (CD34+, monocytes). Few studies have analyzed the impact of latent CMV infections on miscarriage history, pregnancy complications, and neonatal outcomes. Methods: Serum samples from 806 pregnant women (28.29 ± 4.50 years old) who came for a consultation at the Timisoara Clinical Emergency City Hospital between 2008 and 2010 were tested for anti-CMV IgM/IgG antibodies, and data about demography, obstetrical history, pregnancy complications, birth, and neonate were collected. The data were compared between the groups with and without latent CMV infection, and statistical significance was calculated. Results: We did not find a difference regarding cesarean section (OR = 0.916, p = 0.856), placental abruption (OR = 1.004, p = 1.00), pregnancy-induced hypertension rate (OR = 1.078, p = 1.00), secondary sex ratio (0.882, p = 0.857), APGAR score (p = 0.225), gestational age at birth (p = 0.434), or birth weight (p = 0.365). A borderline significant difference was found regarding the presence of miscarriage history: OR = 8.467, p = 0.051. Conclusions: The presence of latent CMV infection does not affect the likelihood of complications in healthy women. A borderline significantly higher prevalence of miscarriage history was found in women with latent CMV infection.

show abstract

Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

Mocanu,

Stoian,

Daescu

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Likewise, a recent seroepidemiological study in Croatia showed comparable RV and CMV seroprevalence rates between different age groups of WCBA [14]. However, an age-related trend in terms of presence of CMV IgGs has been determined in central Italy, with a lower seroprevalence in younger people [27]. In addition, a significant positive correlation with age groups was previously described for TOX seropositivity, with a markedly increased reactivity in older people [10, 14].…”

Section: Discussionmentioning

confidence: 87%

Serological status for TORCH in women of childbearing age: a decade-long surveillance (2012–2022) in Italy

Palazzotto

Bonura

Calà

et al. 2023

Journal of Medical Microbiology

View full text Add to dashboard Cite

Introduction. Serological screening and seroprevalence data for TORCH infections represent a key instrument to estimate immunity and vaccination levels and exposure rates to prevent and treat TORCH congenital infections. Hypothesis. Serology allows us to identify women susceptible to primary infection. Aim. Assess the prevalence of women at risk of primary infections by TORCH pathogens in Palermo, Sicily, Italy, in the decade 2012–2022. Methodology. A retrospective study was performed to evaluate the serological status (IgG and/or IgM) of 2359 women of childbearing age (WCBA), ranging from 16 to 46 years, attending the AOUP ‘P. Giaccone’ University Hospital of Palermo. Results. The results showed an overall prevalence of anti-TORCH IgG of 90.5 % for herpesvirus (HSV), 81.2 % for rubella virus (RV), 72.1 % for cytomegalovirus (CMV), 20.9 % for Toxoplasma gondii (TOX) and 4.8 % for Treponema pallidum (TP). IgM positivity was 16.9 % for HSV2, 10.3 % for TOX, 4 % for CMV and, 2 % for RV. A recent/active infection by TP was confirmed in 28.3 % of the seropositive women. Our results indicate that only a small percentage of WCBA were subjected to a comprehensive TORCH serological screening, while most WCBA were only tested for a single pathogen. In addition, no significant differences were found in terms of the overall TORCH IgG seroprevalence among different age groups (P>0.05). Conclusion. Identifying WCBA at risk of exposure during pregnancy allows us to prevent and reduce possible congenital infections, providing detailed guidelines and instructions. The results of this study showed that in Italy the risk of acquiring a primary infection by a TORCH agent is still high, therefore effective prevention strategies, including serological screening, should be implemented.

show abstract

Impact of time-temperature combinations on the anti-Cytomegalovirus activity and biological components of human milk

et al. 2023

View full text Add to dashboard Cite

Seroprevalence of antibodies to cytomegalovirus in pregnant women in the Apulia region (Italy)

Cited by 4 publications

References 33 publications

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

Serological status for TORCH in women of childbearing age: a decade-long surveillance (2012–2022) in Italy

Impact of time-temperature combinations on the anti-Cytomegalovirus activity and biological components of human milk

Contact Info

Product

Resources

About