Seroprevalence of hepatitis B and hepatitis C viral infections among blood donors of Central Karnataka, India

Bommanahalli, Basavaraj P.; Javali, Rudramma; Swamy, Mallikarjuna; Gouda, Kavita; Siddartha, K; Kp, Shashikala

doi:10.5455/ijmsph.2013.151220131

Cited by 15 publications

(16 citation statements)

References 12 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the other studies conducted were done in 2000, this could also explain the low seroprevalence in the present study. Prevalence of HBV and HCV in our study was low compared to the study conducted by Basavaraj et al 11 because we strictly adhered to voluntary donors. The reduced prevalence in our study could be due to a number of factors.…”

Section: Resultscontrasting

confidence: 68%

Seroprevalence of Transfusion Transmitted Diseases in Voluntary Donors in a Tertiary Care Centre

Dheemantha¹,

Panchakshari²,

Sreelatha³

2014

jemds

View full text Add to dashboard Cite

In India testing for Human Immunodeficiency Virus, Hepatitis-B Virus, Hepatitis-C Virus and Syphilis is mandatory for all blood donors. Transmission of HIV, HBV, HCV and Syphilis through blood and blood products can be reduced to a great extent by efficient and reliable screening of the blood to be transfused. This study was aimed to find out the seroprevalence of the transfusion transmitted diseases. OBJECTIVES: The present study was conducted to estimate the prevalence of transfusion transmitted infections in voluntary blood donors in Victoria hospital blood bank in Bangalore in India. MATERIALS AND METHODS: A retrospective study was conducted with 3910 voluntary blood donors of which 3505 donors were from voluntary blood donation camps and 405 voluntary blood donors donated in blood bank. All donors met the standard inclusion and exclusion criteria followed in India. 1 The donors had donated blood to Victoria hospital, Bangalore from 1 st January 2013 to 31 st December 2013. All voluntary donor's blood sample were tested for HIV,HBV,HCV and Syphilis by HIV-ELISA (Enzyme Linked Immuno-Sorbent Assay), HBSAg-ELISA,HCV-ELISA and Venereal Disease Research Laboratory tests respectively by standard procedures. RESULTS: Out of the total 3910 blood samples tested only 1 donor(0.025%) was HIV positive, 28 donors (0.7%) were HBSAg reactive, none of the samples were HCV reactive, 1 donor (0.025%) was VDRL reactive. CONCLUSION: Though prevalence of HIV, HBV, HCV and Syphilis have reduced over the years. Blood is still one of the main sources of transmission of infections. HIV, hepatitis B, hepatitis C viruses and syphilis are prevalent even among voluntary blood donors.

show abstract

Section: Resultscontrasting

confidence: 68%

Seroprevalence of Transfusion Transmitted Diseases in Voluntary Donors in a Tertiary Care Centre

Dheemantha¹,

Panchakshari²,

Sreelatha³

2014

jemds

View full text Add to dashboard Cite

show abstract

“…Prevalence of HCV in our study was 0.099%, which was comparable with a study conducted at Mangalore (0.06%) [16] and central Karnataka (0.1%). [18] Prevalence of HCV in different studies [3,5,[9][10][11][12][13][14][15]17] in India ranges from 0.21% to 1.62%, which is higher than that of this study. As shown in Table 3, global prevalence of HCV in different studies ranges from 0.3% to 8.7%, which is higher than that of this study.…”

Section: Discussionmentioning

confidence: 59%

“…This could partly be contributed to FDA norms of country that does not permit private hospitals and institutes to conduct voluntary blood donation camps in outside premises. This indicates Eastern part of India [9] 2.27 0.64 1.62 1.62 -Kolkata [10] 1.55 0.32 0.35 0.35 -Haryana [3] 1.7 0.30 1.0 0.9 -Baroda [11] 0.85 0.30 0.21 0.25 -Delhi [5] 2.33 0.56 0.66 --Mysore [12] 1.27 0.49 0.23 0.2815 -Ludhiana [13] 0.66 0.084 1.0 --Lucknow [14] 1.96 0.23 0.85 0.01 -Bhopal [15] 2.9 0.51 0.57 0.23 -Mangalore [16] 0.34 0.06 0.06 0.11 -Bareilly [17] 1.93 0.27 1.02 0.16 -Central Karnataka [18] 2.12 -0.1 -- [19] 1/270,000 1/2,135,000 ---Europe [19] 1/70,000-1,00,000 1/1-5 million ---Philippines [20] 4.2 0.006 0.3 --Thailand [21] 4.61 0.69 2.90 --Nigeria [22] 8.1 3.1 6.0 1.1 -Nepal [23] 0.46 0.12 0.64 --Mongolia [24] 8.1 0 8.7 2.0 -that a lot has to be done in motivating and getting home the message to our donors about the benefits of promoting voluntary donors, which are shown to have a much lower seroprevalence of TTIs. As shown in Table 2, prevalence of HBV among blood donors in most of the Indian studies conducted at eastern part of India, [9] Kolkata, [10] Haryana, [3] Delhi, [5] Mysore, [12] Lucknow, [14] Bhopal, [15] Bareilly, [17] and central Karnataka [18] ranges from 1.27% to 2.99%, which is quite comparable with 1.77% of our study.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of transfusion-transmitted infections (TTIs) in blood donors: a study from central India

Yadav¹,

Varma²,

Singh³

et al. 2016

Int J Med Sci Public Health

View full text Add to dashboard Cite

Background: Transmission of infectious diseases such as HIV, hepatitis, syphilis, and others through donated blood needs a serious monitoring to provide safe blood for transfusion, which forms an integral part of medical and surgical therapy. Objective: To access the seroprevalence of transfusion-transmitted infections (TTIs) in Malwa region and assess the level of blood safety. Material and Methods: A prospective observational study was conducted for the duration of 12 months. The known seropositive donors for any of these infections (HIV, HBV, HCV, syphilis, and malaria) and hemoglobin less than 12.5 g% were excluded. All donor samples were screened for HIV, HBsAg, and anti-HCV by ELISA methods; syphilis and malaria screening was done by card test. Result: Among the total 4,007 donors, 92% were replacement donors while 8% were voluntary donors. Female donors comprised only 1.62%; the remaining 98.38% were male donors. The donor population was mostly in the young age group of 18-30 years (69.1%). Totally, 2.05% (n = 83) blood bags were seropositive for TTI. HBV was the most common TTI (1.77% bags); HIV was the second most common TTI (0.14% bags); HCV was detected in 0.099% bags, whereas syphilis was the least common TTI (0.04% bags). Conclusion: Two to 3% of healthy donors are seropositive for TTI and reveal potential of transmitting them through transfusion. Thus, strict and proper donor selection criteria and screening with higher-generation ELISA kits can help to identify and avoid transfusion of infectious blood products.

show abstract

“…But the result is considerably higher than studies conducted elsewhere, 4.8% [10], 3.4% [13], 1.7% [20], 1.1% [21], 0.51% [22], 0.48% [23], 0.21% [24], 0.2% [17], 0.16% [25], and 0.03% [14]. The higher prevalence of this study as compared with the above findings could be supported by the reason that most of the donations before six years were commercial donors and they were donating blood without being screened for HCV and these strains may be circulating in the community without noticing.…”

Section: Discussionmentioning

confidence: 71%

Transfusion-Transmissible Infections among Voluntary Blood Donors at Wolaita Sodo University Teaching Referral Hospital, South Ethiopia

Bisetegen

Belayneh

Ageru

et al. 2016

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Background. Transfusion-transmissible infections, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis are among the greatest threats to blood safety and pose a serious public health problem. Objective. To determine the magnitude of blood borne infections among blood donors at Wolaita Sodo University Teaching Referral Hospital. Methods and Materials. A cross-sectional study was conducted from 10/11/2015 up to 10/12/2015. 390 donors were consecutively included and data on donor's age, sex, blood type, and serum screening results were obtained by structured questionnaire and laboratory investigation. The collected data were entered into Epi Data version 1.4 and then exported to SPSS version 20.0 for analysis. Result. The seroprevalence of blood borne pathogens is 29.5% of which HCV, HBV, HIV, and syphilis account for 8.5%, 9.5%, 6.4%, and 7.5%, respectively. Multiple infections were observed among 2.8% of the infected individuals. In addition, age ≥ 30 has a significant association with HCV. Conclusion. Significantly higher prevalence of transfusion-transmissible infections was identified from blood donors and they remain to be the greatest threat to blood safety, so comprehensive screening of donors' blood for HIV, HBV, HCV, and syphilis using standard methods is highly recommended to ensure the safety of blood recipient.

show abstract

Seroprevalence of hepatitis B and hepatitis C viral infections among blood donors of Central Karnataka, India

Cited by 15 publications

References 12 publications

Seroprevalence of Transfusion Transmitted Diseases in Voluntary Donors in a Tertiary Care Centre

Seroprevalence of Transfusion Transmitted Diseases in Voluntary Donors in a Tertiary Care Centre

Seroprevalence of transfusion-transmitted infections (TTIs) in blood donors: a study from central India

Transfusion-Transmissible Infections among Voluntary Blood Donors at Wolaita Sodo University Teaching Referral Hospital, South Ethiopia

Contact Info

Product

Resources

About