Seroprevalence of Hepatitis B infection among pregnant women in South India

Rajendiran, Sathiyakala; Gopalan, Ushadevi; Jayakumar, Karthika

doi:10.18203/2320-1770.ijrcog20164668

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…Concerning HBV among pregnant women, a high (5%) prevalence was noted that require prompt screening of pregnant women during their antenatal care visit and provide proper treatment to decrease the rate of mother to child transmission of the virus. Though the result was far higher than recent findings from India 1.01% [102] and Iran (1.18 and 1.25%) conducted at different time periods [103, 104], it was significantly lower compared to the findings from Nigeria 14.1%, Cameroon 11.11%, Burkina Faso 9.8%, and Ghana 13.1% [96–99]. Most probability this variability could be due to the endemicity of the virus among the mentioned countries than Ethiopia or it could be due to the increased attention of the Ethiopian government in providing care and follow-up for the pregnant women which could significantly reduce the transmission and prevalence of HBV among the pregnant women.…”

Section: Discussioncontrasting

confidence: 75%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Tebeje

2019

BMC Infect Dis

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BackgroundHepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from person to person through vertically or horizontally via contaminated body fluids. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly among the developing countries.MethodsOnline electronic databases including PubMed, Google Scholar, Science Direct, African Index Medicus, African Journals Online, and WHO Afro Library were searched and published articles from 2010 to June 8, 2019, were considered. Both authors independently screened articles and extracted the data. Funnel-Plots and Egger’s test statistics were used to determine the presence of small-study effects and publication bias. The pooled prevalence of HBV was analyzed using the random-effects model. The possible sources of heterogeneity was analyzed through subgroup analysis, sensitivity analysis, and meta-regression.ResultsThe overall pooled prevalence of HBV was 6% and among subgroups, pregnant women, healthcare workers, and HIV positive patients accounted for 5% for each group. Relatively low prevalence (4%) was obtained among blood donors. The Egger’s test statistics (p = 0.747) indicated the absence of publication bias. In addition, from the sensitivity analysis, there was no influence on the overall effect estimate while removing a single study at a time. The level of heterogeneity was reduced among pregnant women, HIV positive and studies with unknown sampling techniques. After conducting meta-regression, province, study group, screening method, and quality of papers were identified as sources of heterogeneity.ConclusionsThe overall pooled prevalence of HBV in Ethiopia was high. Strengthening and scaling up of the scope of the existing vaccination program and implementing novel approaches including screen-and-treat could be implemented to reduce the burden of the disease. Generally, the study can provide current prevalence estimate of HBV that could vital for intervention to tackle the disease.

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Section: Discussioncontrasting

confidence: 75%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Tebeje

2019

BMC Infect Dis

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“…Concerning HBV among pregnant women, a high (5%) prevalence was noted that require prompt screening of pregnant women during their antenatal care visit and provide proper treatment to decrease the rate of mother to child transmission of the virus. Though the result was far higher than recent findings from India 1.01% [102] and Iran (1.18% and 1.25%) conducted at different time periods [103,104], it was significantly lower compared to the findings from Nigeria 14.1%, Cameroon 11.11%, Burkina Faso 9.8%, and Ghana 13.1% [96][97][98][99]. Most probability this variability could be due to the endemicity of the virus among the mentioned countries than Ethiopia or it could be due to the increased attention of the Ethiopian government in providing care and followup for the pregnant women which could significantly reduce the transmission and prevalence of HBV among the pregnant women.…”

Section: Discussioncontrasting

confidence: 75%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Girma

2019

Preprint

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Background Hepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from one person to the other through vertically or horizontally via contaminated body fluid exposure. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly in developing countries. Methods Online electronic databases including PubMed, Google Scholar, Science Direct, African Index Medicus, African Journals Online, and WHO Afro Library were searched and published articles from 2010 to June 8, 2019, were considered. Two authors independently screened articles and extracted data. Funnel-Plots and Egger’s test statistics were used to determine the presence of small study effects and publication bias. The pooled prevalence of HBV was analyzed using a random effects model. The possible sources of heterogeneity was analyzed through subgroup analysis, sensitivity analysis, and meta-regression. Results The overall pooled prevalence of HBV was 6% and among subgroups pregnant women, healthcare workers, and HIV positive patients accounted for 5% for each group. Relatively low prevalence (4%) was obtained among blood donors. The Egger’s test statistics (p=0.747) indicated the absence of publication bias. In addition, from the sensitivity analysis, there was no influence on the overall effect while removing a single study at a time. The level of heterogeneity was reduced among pregnant women, HIV positive and studies with unknown sampling techniques. After conducting meta-regression, province, study group, screening method, and quality of papers were identified as sources of heterogeneity. Conclusions The overall pooled prevalence of HBV in Ethiopia was high. Strengthening and scaling up of the scope of the existing vaccination program and implementing novel approaches including screen-and-treat could be implemented to reduce the burden of the disease. Generally, the study can provide current prevalence estimate of HBV that could vital for intervention to tackle the disease.

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“… 12 , 22–24 Similarly, it is higher than study findings from developing countries such as India and Vietnam. 33 , 34 However, it is lower than study findings from Nigeria. 35 This difference may be due to difference in awareness level of the study participants towards the infection, difference in socioeconomic level, sample size and/or study season, study design, methods used for investigation of the virus or government attention level for the infection.…”

Section: Discussionmentioning

confidence: 61%

“…This finding is in line with world-wide cut-off points for higher endemicity level in studies from developing countries. 32 , 33 This indicates that the prevention and vaccination status of pregnant women towards hepatitis B is low, which leads to the higher rate of chronic hepatitis B infection for babies born to hepatitis B infection-positive mothers. The sero-prevalence of hepatitis B infection among pregnant women found by this study is higher than study findings of four studies from Ethiopia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B Virus Infection and Factors Associated with Hepatitis B Virus Infection Among Pregnant Women Presented to Antenatal Care Clinics at Adigrat General Hospital in Northern Ethiopia

Kinfe¹,

Sendo²,

Gebremedhin³

2021

IJWH

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Seroprevalence of Hepatitis B infection among pregnant women in South India

Cited by 10 publications

References 8 publications

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Prevalence of Hepatitis B Virus Infection and Factors Associated with Hepatitis B Virus Infection Among Pregnant Women Presented to Antenatal Care Clinics at Adigrat General Hospital in Northern Ethiopia

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